Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
Overcoming regulatory barriers to the implementation of AI agents in healthcare – Nature
Overcoming regulatory barriers to the implementation of AI agents in healthcare Nature AI in health care could save lives…
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Cancer is a genetic disease stemming from a combination of inherited and acquired mutations. Much of our understanding…
A mixed methods formative evaluation of the United Kingdom National Health Service Artificial Intelligence Lab
We interviewed 85 individuals, reviewed 1021 documents, and conducted 12 observations. A detailed description of the dataset is…
Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
Ethics We received approval to access and analyze deidentified genetic and phenotypic data from the two cohorts from…
Cognitive bias in clinical large language models
Biases affecting clinical LLM systems can arise at multiple stages, including data-related biases from collection and representation, model-related…
Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs
Development of scMicro-C The previously reported bulk Micro-C chemistry, although offering nucleosome-level contact maps, cannot be applied to…
The long-term effects of chemotherapy on normal blood cells
Genome sequencing of chemotherapy-exposed blood To conduct a primary survey of chemotherapy effects on normal blood cell genomes,…
The role of untranslated region variants in Mendelian disease: a review
100,000 Genomes Project Pilot Investigators, Smedley D, Smith KR, Martin A, Thomas EA, McDonagh EM, et al. 100,000…
Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial
Study design This was a pragmatic, assessor-blinded, multicenter, parallel-group RCT (1:1 treatment allocation) with follow-up assessments at 4,…