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Browsing Tag

Biomedicine

113 posts
GGenetics
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics
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Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

  • 10 May 2025
Experimental method detailsHuman participants and ethical approval Frozen GBM specimens that were diagnosed as ‘glioblastoma, IDH-wildtype’ according to…
GGenetics
The multilayered transcriptional architecture of glioblastoma ecosystems
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The multilayered transcriptional architecture of glioblastoma ecosystems

  • 9 May 2025
Participants and ethical approval Frozen GBM specimens, diagnosed as ‘glioblastoma, IDH WT’ according to the WHO 2021 classification,…
GGenetics
Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries | Journal of Translational Medicine
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Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries | Journal of Translational Medicine

  • 8 May 2025
Studies performed using traditional GWAS and meta-GWAS approaches on large patient populations (6,450 cases and 53,764 cases) respectively…
GGenetics
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
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Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

  • 4 May 2025
Isogenic model for TP53 mutagenesis by CRISPR-HDR To assess the functional impact of TP53 variants in a controlled…
GGenetics
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns
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Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

  • 4 May 2025
Human fat depot-specific adipocyte atlases To generate hSAT and hVAT depot-specific human adipocyte atlases, we performed single-nucleus RNA…
GGenetics
Genetic insights into infertility from large-scale analyses
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Genetic insights into infertility from large-scale analyses

  • 30 April 2025
World Health Organization. Infertility Prevalence Estimates, 1990–2021 (WHO, 2023). Venkatesh, S. S. et al. Nat. Genet. https://doi.org/10.1038/s41588-025-02156-8 (2025).…
GGenetics
GJA8-associated developmental eye disorders: a new multicentre study highlights mutational hotspots and genotype-phenotype correlations
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GJA8-associated developmental eye disorders: a new multicentre study highlights mutational hotspots and genotype-phenotype correlations

  • 30 April 2025
Here, we report variants affecting GJA8 in 22 individuals from 15 new families, including 11 missense variants predicted…
GGenetics
Oryza genome evolution through a tetraploid lens
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Oryza genome evolution through a tetraploid lens

  • 28 April 2025
Tanksley, S. D. & McCouch, S. R. Seed banks and molecular maps: unlocking genetic potential from the wild.…
GGenetics
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis
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Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

  • 28 April 2025
Participants and samples The studies described here comply with ethical regulations as approved under local institutional review boards,…
GGermany
Evaluating the COVID-19 responses of Belgium, Denmark, Germany, the Netherlands, Sweden, and the United Kingdom, February–June 2020: a counterfactual modeling study | BMC Medicine
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Evaluating the COVID-19 responses of Belgium, Denmark, Germany, the Netherlands, Sweden, and the United Kingdom, February–June 2020: a counterfactual modeling study | BMC Medicine

  • 28 April 2025
This analysis quantifies the potential impact of different pandemic responses on COVID-19 mortality in six Northwestern European countries…
United Kingdom
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