Sex and smoking bias in the selection of somatic mutations in human bladder
Sample collection Two epithelial brushes (2–3 cm2) from the bladder top (dome) and the bladder floor (trigone) were obtained…
Somatic mutation and selection at population scale
Cohort selection The TwinsUK study contains around 16,000 participants. From a preselection of 4,800 donors, we invited 1,796…
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
Quantitative models of resistance evolution We developed mathematical models of resistance evolution that described the response of a…