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Browsing Tag

Cancer Research

87 posts
GGenetics
Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs
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Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs

  • 7 July 2025
Development of scMicro-C The previously reported bulk Micro-C chemistry, although offering nucleosome-level contact maps, cannot be applied to…
GGenetics
The long-term effects of chemotherapy on normal blood cells
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The long-term effects of chemotherapy on normal blood cells

  • 6 July 2025
Genome sequencing of chemotherapy-exposed blood To conduct a primary survey of chemotherapy effects on normal blood cell genomes,…
FFitness
Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial
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Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial

  • 1 July 2025
Study design This was a pragmatic, assessor-blinded, multicenter, parallel-group RCT (1:1 treatment allocation) with follow-up assessments at 4,…
GGenetics
Predicting resistance to chemotherapy using chromosomal instability signatures
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Predicting resistance to chemotherapy using chromosomal instability signatures

  • 28 June 2025
CIN signatures as biomarkers of chemotherapy resistance The presence of CIN in a tumor has long been recognized…
GGenetics
How and when organisms edit their own genomes
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How and when organisms edit their own genomes

  • 28 June 2025
Lindahl, T. Instability and decay of the primary structure of DNA. Nature 362, 709–715 (1993). Article  CAS  PubMed …
GGenetics
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network
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Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

  • 26 June 2025
Lewis, J. D. et al. Incidence, prevalence, and racial and ethnic distribution of inflammatory bowel disease in the…
GGenetics
Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis
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Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis

  • 25 June 2025
Diehl, A. M. & Day, C. Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis. N. Engl. J. Med. 377,…
GGenetics
Using large-scale population-based data to improve disease risk assessment of clinical variants
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Using large-scale population-based data to improve disease risk assessment of clinical variants

  • 23 June 2025
Turro, E. et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature 583,…
GGenetics
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
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Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design

  • 21 June 2025
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…
GGenetics
RNA polymerase II transcription compartments — from factories to condensates
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RNA polymerase II transcription compartments — from factories to condensates

  • 19 June 2025
Baum, M., Erdel, F., Wachsmuth, M. & Rippe, K. Retrieving the intracellular topology from multi-scale protein mobility mapping…
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