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Browsing Tag

Cancer Research

70 posts
GGenetics
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring
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Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring

  • 15 April 2025
Single-cell longitudinal profiling reveals microenvironmental shifts We profiled neuroblastoma samples from 22 patients with high-risk neuroblastoma obtained through…
GGenetics
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
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Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

  • 14 April 2025
Crick, F. Molecular biology in the year 2000. Nature 228, 613–615 (1970). Article  CAS  PubMed  Google Scholar  Crick,…
GGenetics
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum
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Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

  • 14 April 2025
Genome-wide meta-analyses identify new loci for infertility We identified female infertility of all causes (F-ALL), anatomical causes (F-ANAT),…
GGenetics
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
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Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

  • 14 April 2025
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew…
GGenetics
The genetic basis of human height
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The genetic basis of human height

  • 13 April 2025
Tanner, J. M. A History of the Study of Human Growth (Cambridge Univ. Press, 1981). Galton, F. Regression…
GGenetics
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
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Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum

  • 13 April 2025
Ziaeian, B. & Fonarow, G. C. Epidemiology and aetiology of heart failure. Nat. Rev. Cardiol. 13, 368–378 (2016).…
GGenetics
A redefined InDel taxonomy provides insights into mutational signatures
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A redefined InDel taxonomy provides insights into mutational signatures

  • 12 April 2025
Diversity of InDel patterns in PRRd We generated a ‘ground truth’ set of isogenic cellular models by introducing…
GGenetics
Quantitative characterization of cell niches in spatially resolved omics data
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Quantitative characterization of cell niches in spatially resolved omics data

  • 11 April 2025
This study relies on the analysis of previously published data, adhering to ethical guidelines for human and mouse…
GGenetics
Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorder
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Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorder

  • 11 April 2025
To expand the search for genes implicated in bipolar disorder, we performed a genome-wide LOF burden scan of…
GGenetics
Author Correction: Identification of genetic elements that autonomously determine DNA methylation states
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Author Correction: Identification of genetic elements that autonomously determine DNA methylation states

  • 10 April 2025
Cite this article Lienert, F., Wirbelauer, C., Som, I. et al. Author Correction: Identification of genetic elements that…
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