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Browsing Tag

Cancer Research

93 posts
GGenetics
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
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Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

  • 18 May 2025
Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany Nora I. Strom, Julia Klawohn & Norbert Kathmann Department of Psychiatric Phenomics and…
GGenetics
APOBEC3 mutagenesis drives therapy resistance in breast cancer
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APOBEC3 mutagenesis drives therapy resistance in breast cancer

  • 17 May 2025
Study cohort This study was approved by the Memorial Sloan Kettering Cancer Center (MSKCC) Institutional Review Board (12-245)…
GGenetics
Three-dimensional genome landscape of primary human cancers
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Three-dimensional genome landscape of primary human cancers

  • 12 May 2025
Multiple scales of 3D genome organization in human cancers We profiled genome-wide chromosome conformation in 69 tumor samples…
GGenetics
One but not the same — the many genomes of the brain
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One but not the same — the many genomes of the brain

  • 10 May 2025
The human brain exhibits enormous complexity, with many thousands of cell types performing specialized functions that provide the…
GGenetics
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics
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Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

  • 10 May 2025
Experimental method detailsHuman participants and ethical approval Frozen GBM specimens that were diagnosed as ‘glioblastoma, IDH-wildtype’ according to…
GGenetics
The multilayered transcriptional architecture of glioblastoma ecosystems
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The multilayered transcriptional architecture of glioblastoma ecosystems

  • 9 May 2025
Participants and ethical approval Frozen GBM specimens, diagnosed as ‘glioblastoma, IDH WT’ according to the WHO 2021 classification,…
GGenetics
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
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Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

  • 4 May 2025
Isogenic model for TP53 mutagenesis by CRISPR-HDR To assess the functional impact of TP53 variants in a controlled…
GGenetics
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns
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Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

  • 4 May 2025
Human fat depot-specific adipocyte atlases To generate hSAT and hVAT depot-specific human adipocyte atlases, we performed single-nucleus RNA…
GGenetics
Genetic insights into infertility from large-scale analyses
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Genetic insights into infertility from large-scale analyses

  • 30 April 2025
World Health Organization. Infertility Prevalence Estimates, 1990–2021 (WHO, 2023). Venkatesh, S. S. et al. Nat. Genet. https://doi.org/10.1038/s41588-025-02156-8 (2025).…
GGenetics
Oryza genome evolution through a tetraploid lens
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Oryza genome evolution through a tetraploid lens

  • 28 April 2025
Tanksley, S. D. & McCouch, S. R. Seed banks and molecular maps: unlocking genetic potential from the wild.…
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