Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
Clone copy number diversity is linked to survival in lung cancer
The ALPACA algorithm We introduce ALPACA, an algorithm to infer allele-specific copy-number profiles of every tumour clone, given…
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
Quantitative models of resistance evolution We developed mathematical models of resistance evolution that described the response of a…