Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters
Inclusion criteria and ethical considerations Between 7.5 and 15 ml of patient blood in EDTA vacutainers was collected upon…
Plasma proteome variation and its genetic determinants in children and adolescents
Discovery and replication cohorts Our discovery cohort included 2,147 children and adolescents aged 5–20 years from the HOLBAEK Study,…
Searching for the origin of human brain tumours
The anatomical location and cell type from which tumours originate has biological, diagnostic and therapeutic implications, but understanding…
Genome synteny reveals hidden enhancer conservation
Long, H. K., Prescott, S. L. & Wysocka, J. Cell 167, 1170–1187 (2016). Article CAS PubMed PubMed Central …
Genomic landscape of multiple myeloma and its precursor conditions
The MM-like genomic score captures disease progression To characterize the somatic mutation landscape and drivers in precursor conditions…
Genome-wide association study of long COVID
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Vilma…
A crossroads in the timeline of human evolution
Ancient DNA (aDNA) sequencing is like unlocking a genetic time capsule, almost bringing the past back to life…
The impact of public insurance on RRSO for HBOC in Japan: a nationwide data study
JOHBOC Registration Committee: Masami Arai (Department of Clinical Genetics, Juntendo University, Graduate School of Medicine, Tokyo, Japan), Seigo…
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH
Gene regulatory networks control functional phenotypes in cells and tissues. In complex tissues, these networks span cells and…
The contribution of gametic phase disequilibrium to the heritability of complex traits
Yang, J. et al. Common SNPs explain a large proportion of the heritability for human height. Nat. Genet.…