RNA polymerase II transcription compartments — from factories to condensates
Baum, M., Erdel, F., Wachsmuth, M. & Rippe, K. Retrieving the intracellular topology from multi-scale protein mobility mapping…
Review of 40 genes causing congenital myasthenic syndromes
Ohno K, Ohkawara B, Shen XM, Selcen D, Engel AG. Clinical and pathologic features of congenital myasthenic syndromes…
Genetic modifiers of somatic expansion and clinical phenotypes in Huntington’s disease highlight shared and tissue-specific effects
Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on…
Genomics of host–microbiome interactions in humans
Valdes, A. M., Walter, J., Segal, E. & Spector, T. D. Role of the gut microbiota in nutrition…
Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters
Inclusion criteria and ethical considerations Between 7.5 and 15 ml of patient blood in EDTA vacutainers was collected upon…
Plasma proteome variation and its genetic determinants in children and adolescents
Discovery and replication cohorts Our discovery cohort included 2,147 children and adolescents aged 5–20 years from the HOLBAEK Study,…
Searching for the origin of human brain tumours
The anatomical location and cell type from which tumours originate has biological, diagnostic and therapeutic implications, but understanding…
Genome synteny reveals hidden enhancer conservation
Long, H. K., Prescott, S. L. & Wysocka, J. Cell 167, 1170–1187 (2016). Article CAS PubMed PubMed Central …
Genomic landscape of multiple myeloma and its precursor conditions
The MM-like genomic score captures disease progression To characterize the somatic mutation landscape and drivers in precursor conditions…
Genome-wide association study of long COVID
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Vilma…