Biology is complex and diverse, so scientific research approaches need to be too
The beautiful, fascinating and often perplexing world around us grows from intricate and convoluted interactions of millions of…
The role of untranslated region variants in Mendelian disease: a review
100,000 Genomes Project Pilot Investigators, Smedley D, Smith KR, Martin A, Thomas EA, McDonagh EM, et al. 100,000…
Range extender mediates long-distance enhancer activity
Bower, G. & Kvon, E. Z. Genetic factors mediating long-range enhancer-promoter communication in mammalian development. Curr. Opin. Genet.…
Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line
Ethics approval All animals involved in this study were housed and treated in accordance with the guidelines approved…
Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis
Diehl, A. M. & Day, C. Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis. N. Engl. J. Med. 377,…
Genome synteny reveals hidden enhancer conservation
Long, H. K., Prescott, S. L. & Wysocka, J. Cell 167, 1170–1187 (2016). Article CAS PubMed PubMed Central …
Three-dimensional genome landscape of primary human cancers
Multiple scales of 3D genome organization in human cancers We profiled genome-wide chromosome conformation in 69 tumor samples…
Genetic regulation of gene expression across multiple tissues in chickens
Hillier, L. W. & Miller, W. Sequence and comparative analysis of the chicken genome provide unique perspectives on…