Mapping genetic diversity with the GenomeIndia project – Nature
Mapping genetic diversity with the GenomeIndia project Nature A unique genome database of 10,000 ‘healthy’ Indians is ready for…
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring
Single-cell longitudinal profiling reveals microenvironmental shifts We profiled neuroblastoma samples from 22 patients with high-risk neuroblastoma obtained through…
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Crick, F. Molecular biology in the year 2000. Nature 228, 613–615 (1970). Article CAS PubMed Google Scholar Crick,…
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum
Genome-wide meta-analyses identify new loci for infertility We identified female infertility of all causes (F-ALL), anatomical causes (F-ANAT),…
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew…
The genetic basis of human height
Tanner, J. M. A History of the Study of Human Growth (Cambridge Univ. Press, 1981). Galton, F. Regression…
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Ziaeian, B. & Fonarow, G. C. Epidemiology and aetiology of heart failure. Nat. Rev. Cardiol. 13, 368–378 (2016).…
A redefined InDel taxonomy provides insights into mutational signatures
Diversity of InDel patterns in PRRd We generated a ‘ground truth’ set of isogenic cellular models by introducing…
Quantitative characterization of cell niches in spatially resolved omics data
This study relies on the analysis of previously published data, adhering to ethical guidelines for human and mouse…
Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorder
To expand the search for genes implicated in bipolar disorder, we performed a genome-wide LOF burden scan of…