Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
Deep learning reveals antibiotics in the archaeal proteome
Deep-learning-guided identification of archaeasins We collected 18,677 non-redundant reviewed protein sequences from 233 archaeal organisms available on UniProt10…
Morphological map of under- and overexpression of genes in human cells
Mattiazzi Usaj, M. et al. High-content screening for quantitative cell biology. Trends Cell Biol. 26, 598–611 (2016). CAS …
The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
GeneAgent: self-verification language agent for gene-set analysis using domain databases
Model setting and data collection In this work, we utilized GPT-4 (version 20230613) as the backend model via…
Recognify’s Phase IIb trial of schizophrenia therapy fails to meet primary goal
atai Life Sciences (ATAI) company Recognify Life Sciences has reported that its Phase IIb trial of oral compound,…
Population-level gene copy number variations reveal distinct genetic properties of different Malus species | BMC Genomics
Weischenfeldt J, Symmons O, Spitz F, Korbel JO. Phenotypic impact of genomic structural variation: insights from and for…
Healthy Life: Ancient viruses in our DNA may hold clues to what makes us human | Healthy Life
Fragments of ancient viral DNA once dismissed as “junk” may play a role in controlling our genes, according…
Alien plants and novel ecosystems in the Greater Tropics
Barlow, J. et al. The future of hyperdiverse tropical ecosystems. Nature 559, 517–526 (2018). CAS Google Scholar Burgin,…
Researchers develop tool to improve genetic predictions
Staff at Pusan National University CRISPR-based gene editing holds great promise, but off-target effects remain a major concern,…