Spatial architecture of development and disease
Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …
Imaging-based multimodal profiling of single cells with STAMP
Single-cell RNA sequencing (scRNA-seq) has dramatically advanced our ability to dissect complex biological systems at cellular resolution. However,…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar García-García,…
Precisely defining disease variant effects in CRISPR-edited single cells
Cell-line cultures and genomic editing HH cutaneous T cell lines (ATCC, CRL-2105), Jurkat E6-1 (ATCC, TIB-152) and Daudi…
Mapping genetic activity offers new clues for personalized cancer treatment
City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S.…
RNA-based diagnostic studies in genetics: Review and guidance from a multidisciplinary French network
Cheung R, Insigne KD, Yao D, Burghard CP, Wang J, Hsiao Y-HE, et al. A multiplexed assay for…
Genomics could hold the key to stroke risk, U of A researchers say
A team of University of Alberta researchers has been granted $4.79 million over four years to better understand…
The landscape of N6-methyladenosine in localized primary prostate cancer
The m6A landscape of localized prostate cancer We quantified the epitranscriptomes of 162 primary localized prostate tumors using…
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring
Single-cell longitudinal profiling reveals microenvironmental shifts We profiled neuroblastoma samples from 22 patients with high-risk neuroblastoma obtained through…
Quantitative characterization of cell niches in spatially resolved omics data
This study relies on the analysis of previously published data, adhering to ethical guidelines for human and mouse…