{"id":1004200,"date":"2026-06-04T05:33:27","date_gmt":"2026-06-04T05:33:27","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/1004200\/"},"modified":"2026-06-04T05:33:27","modified_gmt":"2026-06-04T05:33:27","slug":"single-shot-full-field-x-ray-imaging-with-10-nm-resolution-using-hard-x-ray-free-electron-laser-pulses","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/1004200\/","title":{"rendered":"Single-shot full-field X-ray imaging with 10-nm resolution using hard X-ray free-electron laser pulses"},"content":{"rendered":"
  • \n

    Miao, J., Charalambous, P., Kirz, J. & Sayre, D. Extending the methodology of X-ray crystallography to allow imaging of micrometre-sized non-crystalline specimens. Nature 400<\/b>, 342\u2013344 (1999).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chapman, H. N. et al. Femtosecond diffractive imaging with a soft-X-ray free-electron laser. Nat. Phys. 2<\/b>, 839\u2013843 (2006).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Miao, J., Ishikawa, T., Robinson, I. K. & Murnane, M. M. Beyond crystallography: diffractive imaging using coherent X-ray light sources. Science 348<\/b>, 530\u2013535 (2015).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n     MathSciNet<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rodenburg, J. M. & Faulkner, H. M. A phase retrieval algorithm for shifting illumination. Appl. Phys. Lett. 85<\/b>, 4795\u20134797 (2004).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Thibault, P. et al. High-resolution scanning X-ray diffraction microscopy. Science 321<\/b>, 379\u2013382 (2008).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Pfeiffer, F. X-ray ptychography. Nat. Photon. 12<\/b>, 9\u201317 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Odstr\u010dil, M., Holler, M. & Guizar-Sicairos, M. Arbitrary-path fly-scan ptychography. Opt. Express 26<\/b>, 12585\u201312593 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Deng, J. et al. The Velociprobe: an ultrafast hard X-ray nanoprobe for high-resolution ptychographic imaging. Rev. Sci. Instrum. 90<\/b>, 083701 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jiang, Y. et al. Achieving high spatial resolution in a large field-of-view using lensless X-ray imaging. Appl. Phys. Lett. 119<\/b>, 124101 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Aidukas, T. et al. High-performance 4-nm-resolution X-ray tomography using burst ptychography. Nature 632<\/b>, 81\u201388 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chapman, H. N. Fourth-generation light sources. IUCrJ 10<\/b>, 246\u2013247 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kondratenko, K. & Saldin, E. Generating of coherent radiation by a relativistic electron beam in an ondulator. Part. Accel. 10<\/b>, 207\u2013216 (1980).<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bonifacio, R., Pellegrini, C. & Narducci, L. M. Collective instabilities and high-gain regime in a free-electron laser. Opt. Commun. 50<\/b>, 373\u2013377 (1984).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Franz, P. et al. Terawatt-scale attosecond X-ray pulses from a cascaded superradiant free-electron laser. Nat. Photon. 18<\/b>, 698\u2013703 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Neutze, R., Wouts, R., Van der Spoel, D., Weckert, E. & Hajdu, J. Potential for biomolecular imaging with femtosecond X-ray pulses. Nature 406<\/b>, 752\u2013757 (2000).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gaffney, K. J. & Chapman, H. N. Imaging atomic structure and dynamics with ultrafast X-ray scattering. Science 316<\/b>, 1444\u20131448 (2007).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Xu, R. et al. Single-shot three-dimensional structure determination of nanocrystals with femtosecond X-ray free-electron laser pulses. Nat. Commun. 5<\/b>, 4061 (2014).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ihm, Y. et al. Direct observation of picosecond melting and disintegration of metallic nanoparticles. Nat. Commun. 10<\/b>, 2411 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Assalauova, D. et al. An advanced workflow for single-particle imaging with the limited data at an X-ray free-electron laser. IUCrJ 7<\/b>, 1102\u20131113 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yumoto, H. et al. High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging. Nat. Commun. 13<\/b>, 5300 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gabor, D. A new microscopic principle. Nature 161<\/b>, 777\u2013778 (1949).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Aoki, S. & Kikuta, S. X-ray holographic microscopy. Jpn. J. Appl. Phys. 13<\/b>, 1385 (1974).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Cloetens, P. et al. Holotomography: quantitative phase tomography with micrometer resolution using hard synchrotron radiation X rays. Appl. Phys. Lett. 75<\/b>, 2912\u20132914 (1999).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Croton, L. C. P. et al. In situ phase contrast X-ray brain CT. Sci Rep. 8<\/b>, 11412 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Garc\u00eda-Moreno, F. et al. Using X-ray tomoscopy to explore the dynamics of foaming metal. Nat. Commun. 10<\/b>, 3762 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kuan, A. T. et al. Dense neuronal reconstruction through X-ray holographic nano-tomography. Nat. Neurosci. 23<\/b>, 1637\u20131643 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kirkpatrick, P. & Baez, A. V. Formation of optical images by X-rays. J. Opt. Soc. Am. 38<\/b>, 766\u2013774 (1948).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mimura, H. et al. Generation of 1020\u2009W\u2009cm\u22122 hard X-ray laser pulses with two-stage reflective focusing system. Nat. Commun. 5<\/b>, 3539 (2014).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kr\u00fcger, S. P. et al. Sub-10 nm beam confinement by X-ray waveguides: design, fabrication and characterization of optical properties. J. Synchrotron Rad. 19<\/b>, 227\u2013236 (2012).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Snigirev, A., Kohn, V., Snigireva, I., Souvorov, A. & Lengeler, B. Focusing high-energy X rays by compound refractive lenses. Appl. Opt. 37<\/b>, 653\u2013662 (1998).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bajt, S. et al. X-ray focusing with efficient high-NA multilayer Laue lenses. Light: Sci. Appl. 7<\/b>, 17162 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mohacsi, I. et al. Interlaced zone plate optics for hard X-ray imaging in the 10\u2009nm range. Sci Rep. 7<\/b>, 43624 (2017).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Vassholz, M. et al. Pump-probe X-ray holographic imaging of laser-induced cavitation bubbles with femtosecond FEL pulses. Nat. Commun. 12<\/b>, 3468 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hagemann, J. et al. Single-pulse phase-contrast imaging at free-electron lasers in the hard X-ray regime. J. Synchrotron Rad. 28<\/b>, 52\u201363 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Vassholz, M. et al. Structural dynamics of water in a supersonic shockwave. Phys. Fluids 35<\/b>, 016126 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hoeppe, H. P. et al. The collapse of a sonoluminescent cavitation bubble imaged with X-ray free-electron laser pulses. New J. Phys. 26<\/b>, 033002 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yamada, J. et al. Extreme focusing of hard X-ray free-electron laser pulses enables 7\u2009nm focus width and 1022\u2009W\u2009cm\u22122 intensity. Nat. Photon. 18<\/b>, 685\u2013690 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ishikawa, T. et al. A compact X-ray free-electron laser emitting in the sub-\u00e5ngstr\u00f6m region. Nat. Photon. 6<\/b>, 540\u2013544 (2012).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Inoue, I. et al. X-ray Hanbury Brown\u2013Twiss interferometry for determination of ultrashort electron-bunch duration. Phys. Rev. Accel. Beams 21<\/b>, 080704 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Inoue, I. et al. Shortening X-ray pulse duration via saturable absorption. Phys. Rev. Lett. 127<\/b>, 163903 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Osaka, T. et al. Hard x-ray intensity autocorrelation using direct two-photon absorption. Phys. Rev. Res. 4<\/b>, L012035 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Odstrcil, M. et al. Ptychographic coherent diffractive imaging with orthogonal probe relaxation. Opt. Express 24<\/b>, 8360\u20138369 (2016).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Abbey, B. et al. Keyhole coherent diffractive imaging. Nat. Phys 4<\/b>, 394\u2013398 (2008).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Takazawa, S. et al. Demonstration of single-frame coherent X-ray diffraction imaging using triangular aperture: towards dynamic nanoimaging of extended objects. Opt. Express 29<\/b>, 14394\u201314402 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Soltau, J. et al. In-line holography with hard x-rays at sub-15\u2009nm resolution. Optica 8<\/b>, 818\u2013823 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Homann, C. et al. Validity of the empty-beam correction in near-field imaging. Phys. Rev. A 91<\/b>, 013821 (2015).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yamada, J. et al. X-ray single-grating interferometry for wavefront measurement and correction of hard X-ray nanofocusing mirrors. Sensors 20<\/b>, 7356 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Maiden, A. M. & Rodenburg, J. M. An improved ptychographical phase retrieval algorithm for diffractive imaging. Ultramicroscopy 109<\/b>, 1256\u20131262 (2009).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lagarias, J. C., Reeds, J. A., Wright, M. H. & Wright, P. E. Convergence properties of the Nelder\u2013Mead simplex method in low dimensions. SIAM J. Optim. 9<\/b>, 112\u2013147 (1998).<\/p>\n

    Article<\/a>\u00a0
    \n     MathSciNet<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Virtanen, P. et al. SciPy 1.0: fundamental algorithms for scientific computing in Python. Nat. Methods 17<\/b>, 261\u2013272 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dierolf, M. et al. Ptychographic coherent diffractive imaging of weakly scattering specimens. New J. Phys. 12<\/b>, 035017 (2010).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"Miao, J., Charalambous, P., Kirz, J. & Sayre, D. Extending the methodology of X-ray crystallography to allow imaging…\n","protected":false},"author":2,"featured_media":1004201,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[3845],"tags":[14906,3968,7368,79453,74,11112,70,16,15],"class_list":["post-1004200","post","type-post","status-publish","format-standard","has-post-thumbnail","category-physics","tag-applied-and-technical-physics","tag-general","tag-imaging-and-sensing","tag-imaging-techniques","tag-physics","tag-quantum-physics","tag-science","tag-uk","tag-united-kingdom"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/116690210654132149","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/1004200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=1004200"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/1004200\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/1004201"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=1004200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=1004200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=1004200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}