While the study was still in the recruitment phase, Nadolsky left the team.<\/p>\n
Entrenched Positions<\/p>\n
Klatt, of UC Berkeley, is extremely well-versed in nutrition research and the current online debates around cholesterol. He\u2019s written about this study<\/a> and its fallout on his personal Substack, and calls Nadolsky a friend. Klatt discussed the study with Nadolsky while it was ongoing, and many aspects concerned him.<\/p>\n Klatt brought up issues of undisclosed biases to the Lundquist Institute, the host of the trial, along with Dave Feldman\u2019s \u201cstrongly vested interest\u201d in the results of the study that was not properly disclosed, claiming he was \u201ca conflicted party with no training in the biomedical sciences.\u201d His email to the Institute about these issues went unanswered. \u201cI think this study has gotten to the point of being extremely unethical,\u201d Klatt says.<\/p>\n \u201cAll authors adhered to the conflicts-of-interest disclosure guidelines the journal required,\u201d Soto-Mata says. \u201cOur study was independently reviewed, approved, and monitored by an expert Research Ethics committee, all its recommendations were followed, and all its standards were met.\u201d<\/p>\n While some researchers and physicians are tearing the study apart, or using it to show that keto can have adverse effects, Klatt doesn\u2019t draw any strong conclusions. \u201cPeople are talking past each other,\u201d he says. Generally speaking, there are two clear camps, with one thinking the traditional lipid hypothesis holds up, and another thinking the new lipid energy model might work. Klatt puts himself in a third camp, asking: \u201cWhy are we trying to interpret this study at all?\u201d<\/p>\n \u201cI\u2019m an editor at the American Journal of Clinical Nutrition,\u201d Klatt says, \u201cand I would like to believe that we would have rejected this outright without even sending it out for peer review, because it has so many obvious issues.\u201d He is worried about people using this flawed study as proof the consensus on the risks of LDL cholesterol has been \u201cdebunked,\u201d which it has not.<\/p>\n One of the study\u2019s coauthors, Matthew Budoff, a professor of medicine at UCLA as well as an investigator at the Lundquist Institute, acknowledged in an email to WIRED that there had been \u201cincredible scrutiny of the data on social media, which is more than expected based on my prior publications.\u201d He noted the research team is seeking to have the paper incorporate corrections, but that this is ultimately at the discretion of the journal. A response to the Letter to the Editor from the coauthors clarifies some of the issues, he wrote.<\/p>\n That reply to the Letter to the Editor has now been published<\/a>\u2014and reveals that the study\u2019s data may support the conventional position on the risk of cholesterol after all. The study\u2019s authors share that the \u201cpooled median change\u201d in NCPV in the participants\u2014the rise in the type of plaque the study was set up to investigate, but which originally wasn\u2019t explicitly quantified in the paper\u2014was an alarming 42.8 percent. The reply goes on to state that the study\u2019s findings were \u201ccompatible with a causal role of ApoB in atherosclerosis\u201d\u2014the build-up of fat in the arteries\u2014which they\u2019ve \u201cacknowledged and supported in previous publications.\u201d The letter says that not mentioning this percentage increase in NCPV \u201cwas a sincere oversight, not intentional selective reporting.\u201d<\/p>\n But this concession comes after the horse has bolted. Feldman\u2019s hypothesis is already appearing in laypeople\u2019s research\u2014with the keto diet having been among the most Googled diets<\/a> in recent years, and keto products a growing multibillion-dollar industry. Answering the query \u201cWhat is special about Lean Mass Hyper-Responders,\u201d ChatGPT provides the lipid energy model, Feldman\u2019s argument against the consensus on cholesterol, among the initial explanations for why there is so much controversy and interest. There is also a Cholesterol Code documentary<\/a> in the works\u2014which covers Feldman\u2019s personal experience and his research, including this study\u2014which Feldman predicts will be available on a major streaming service sometime this year.<\/p>\n","protected":false},"excerpt":{"rendered":"While the study was still in the recruitment phase, Nadolsky left the team. Entrenched Positions Klatt, of UC…\n","protected":false},"author":2,"featured_media":157438,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4318],"tags":[372,1203,105,4434,70,4173,16,15],"class_list":{"0":"post-157437","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nutrition","8":"tag-diet","9":"tag-food","10":"tag-health","11":"tag-nutrition","12":"tag-science","13":"tag-scientific-research","14":"tag-uk","15":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114625028549142245","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/157437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=157437"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/157437\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/157438"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=157437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=157437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=157437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}