{"id":158865,"date":"2025-06-05T00:32:12","date_gmt":"2025-06-05T00:32:12","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/158865\/"},"modified":"2025-06-05T00:32:12","modified_gmt":"2025-06-05T00:32:12","slug":"pseudohypoxia-caused-by-germline-genetic-alterations-in-the-vhl-gene-is-associated-with-increased-diabetes-and-cardiovascular-risk-a-uk-biobank-study-cardiovascular-diabetology","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/158865\/","title":{"rendered":"Pseudohypoxia caused by germline genetic alterations in the VHL gene is associated with increased diabetes and cardiovascular risk: a UK biobank study | Cardiovascular Diabetology"},"content":{"rendered":"<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"1.\">\n<p class=\"c-article-references__text\" id=\"ref-CR1\">Buckley M, Terwagne C, Ganner A, Cubitt L, Brewer R, Kim DK, et al. Saturation genome editing maps the functional spectrum of pathogenic VHL alleles. Nat Genet. 2024;56(7):1446\u201355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41588-024-01800-z\" data-track-item_id=\"10.1038\/s41588-024-01800-z\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41588-024-01800-z\" aria-label=\"Article reference 1\" data-doi=\"10.1038\/s41588-024-01800-z\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhsV2kurbK\" aria-label=\"CAS reference 1\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38969834\" aria-label=\"PubMed reference 1\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11250436\" aria-label=\"PubMed Central reference 1\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Saturation%20genome%20editing%20maps%20the%20functional%20spectrum%20of%20pathogenic%20VHL%20alleles&amp;journal=Nat%20Genet&amp;doi=10.1038%2Fs41588-024-01800-z&amp;volume=56&amp;issue=7&amp;pages=1446-1455&amp;publication_year=2024&amp;author=Buckley%2CM&amp;author=Terwagne%2CC&amp;author=Ganner%2CA&amp;author=Cubitt%2CL&amp;author=Brewer%2CR&amp;author=Kim%2CDK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"2.\">\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001;292(5516):468\u201372.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.1059796\" data-track-item_id=\"10.1126\/science.1059796\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.1059796\" aria-label=\"Article reference 2\" data-doi=\"10.1126\/science.1059796\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXjtVentb0%3D\" aria-label=\"CAS reference 2\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11292861\" aria-label=\"PubMed reference 2\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20of%20HIF-alpha%20to%20the%20von%20Hippel-Lindau%20ubiquitylation%20complex%20by%20O2-regulated%20prolyl%20hydroxylation&amp;journal=Science&amp;doi=10.1126%2Fscience.1059796&amp;volume=292&amp;issue=5516&amp;pages=468-472&amp;publication_year=2001&amp;author=Jaakkola%2CP&amp;author=Mole%2CDR&amp;author=Tian%2CYM&amp;author=Wilson%2CMI&amp;author=Gielbert%2CJ&amp;author=Gaskell%2CSJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"3.\">\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399(6733):271\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/20459\" data-track-item_id=\"10.1038\/20459\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2F20459\" aria-label=\"Article reference 3\" data-doi=\"10.1038\/20459\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXjsFyqt74%3D\" aria-label=\"CAS reference 3\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10353251\" aria-label=\"PubMed reference 3\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20tumour%20suppressor%20protein%20VHL%20targets%20hypoxia-inducible%20factors%20for%20oxygen-dependent%20proteolysis&amp;journal=Nature&amp;doi=10.1038%2F20459&amp;volume=399&amp;issue=6733&amp;pages=271-275&amp;publication_year=1999&amp;author=Maxwell%2CPH&amp;author=Wiesener%2CMS&amp;author=Chang%2CGW&amp;author=Clifford%2CSC&amp;author=Vaux%2CEC&amp;author=Cockman%2CME\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"4.\">\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Kierans SJ, Taylor CT. Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology. J Physiol Internet. 2020. <a href=\"https:\/\/doi.org\/10.1113\/JP280572\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1113\/JP280572\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1113\/JP280572<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1113\/JP280572\" data-track-item_id=\"10.1113\/JP280572\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1113%2FJP280572\" aria-label=\"Article reference 4\" data-doi=\"10.1113\/JP280572\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20glycolysis%20by%20the%20hypoxia-inducible%20factor%20%28HIF%29%3A%20implications%20for%20cellular%20physiology&amp;journal=J%20Physiol%20Internet.&amp;doi=10.1113%2FJP280572&amp;publication_year=2020&amp;author=Kierans%2CSJ&amp;author=Taylor%2CCT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"5.\">\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Warburg O, Wind F, Negelein E. The metabolism of tumors in the human body. J Gen Physiol [Internet]. 1927;8(6):519\u201330.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1085\/jgp.8.6.519\" data-track-item_id=\"10.1085\/jgp.8.6.519\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1085%2Fjgp.8.6.519\" aria-label=\"Article reference 5\" data-doi=\"10.1085\/jgp.8.6.519\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaB2sXitlyhuw%3D%3D\" aria-label=\"CAS reference 5\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19872213\" aria-label=\"PubMed reference 5\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2140820\" aria-label=\"PubMed Central reference 5\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20metabolism%20of%20tumors%20in%20the%20human%20body&amp;journal=J%20Gen%20Physiol%20%5BInternet%5D.&amp;doi=10.1085%2Fjgp.8.6.519&amp;volume=8&amp;issue=6&amp;pages=519-530&amp;publication_year=1927&amp;author=Warburg%2CO&amp;author=Wind%2CF&amp;author=Negelein%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"6.\">\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene. 2010;29(5):625\u201334.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/onc.2009.441\" data-track-item_id=\"10.1038\/onc.2009.441\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fonc.2009.441\" aria-label=\"Article reference 6\" data-doi=\"10.1038\/onc.2009.441\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhsV2gt77N\" aria-label=\"CAS reference 6\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19946328\" aria-label=\"PubMed reference 6\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Defining%20the%20role%20of%20hypoxia-inducible%20factor%201%20in%20cancer%20biology%20and%20therapeutics&amp;journal=Oncogene&amp;doi=10.1038%2Fonc.2009.441&amp;volume=29&amp;issue=5&amp;pages=625-634&amp;publication_year=2010&amp;author=Semenza%2CGL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"7.\">\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Binderup MLM, Galanakis M, Budtz-J\u00f8rgensen E, Kosteljanetz M, Bisgaard ML. Prevalence, birth incidence, and penetrance of von Hippel-Lindau disease (vHL) in Denmark. Eur J Hum Genet. 2017;25(3):301\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/ejhg.2016.173\" data-track-item_id=\"10.1038\/ejhg.2016.173\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fejhg.2016.173\" aria-label=\"Article reference 7\" data-doi=\"10.1038\/ejhg.2016.173\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XitFehsr7K\" aria-label=\"CAS reference 7\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27966541\" aria-label=\"PubMed reference 7\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Prevalence%2C%20birth%20incidence%2C%20and%20penetrance%20of%20von%20Hippel-Lindau%20disease%20%28vHL%29%20in%20Denmark&amp;journal=Eur%20J%20Hum%20Genet&amp;doi=10.1038%2Fejhg.2016.173&amp;volume=25&amp;issue=3&amp;pages=301-307&amp;publication_year=2017&amp;author=Binderup%2CMLM&amp;author=Galanakis%2CM&amp;author=Budtz-J%C3%B8rgensen%2CE&amp;author=Kosteljanetz%2CM&amp;author=Bisgaard%2CML\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"8.\">\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Maher ER, Iselius L, Yates JRW, Littler M, Benjamin C, Harris R, et al. Von Hippel-Lindau disease: a genetic study. J Med Genet. 1991;28:443\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1136\/jmg.28.7.443\" data-track-item_id=\"10.1136\/jmg.28.7.443\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1136%2Fjmg.28.7.443\" aria-label=\"Article reference 8\" data-doi=\"10.1136\/jmg.28.7.443\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaK3MznsVCktQ%3D%3D\" aria-label=\"CAS reference 8\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1895313\" aria-label=\"PubMed reference 8\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1016952\" aria-label=\"PubMed Central reference 8\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Von%20Hippel-Lindau%20disease%3A%20a%20genetic%20study&amp;journal=J%20Med%20Genet&amp;doi=10.1136%2Fjmg.28.7.443&amp;volume=28&amp;pages=443-447&amp;publication_year=1991&amp;author=Maher%2CER&amp;author=Iselius%2CL&amp;author=Yates%2CJRW&amp;author=Littler%2CM&amp;author=Benjamin%2CC&amp;author=Harris%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"9.\">\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, et al. Von Hippel-Lindau disease. Lancet. 2003;361(9374):2059\u201367.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0140-6736(03)13643-4\" data-track-item_id=\"10.1016\/S0140-6736(03)13643-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0140-6736%2803%2913643-4\" aria-label=\"Article reference 9\" data-doi=\"10.1016\/S0140-6736(03)13643-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXksF2hu7w%3D\" aria-label=\"CAS reference 9\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12814730\" aria-label=\"PubMed reference 9\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Von%20Hippel-Lindau%20disease&amp;journal=Lancet&amp;doi=10.1016%2FS0140-6736%2803%2913643-4&amp;volume=361&amp;issue=9374&amp;pages=2059-2067&amp;publication_year=2003&amp;author=Lonser%2CRR&amp;author=Glenn%2CGM&amp;author=Walther%2CM&amp;author=Chew%2CEY&amp;author=Libutti%2CSK&amp;author=Linehan%2CWM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"10.\">\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Neumann HP, Wiestler OD. Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus. Lancet. 1991;337(8749):1052\u20134.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/0140-6736(91)91705-Y\" data-track-item_id=\"10.1016\/0140-6736(91)91705-Y\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2F0140-6736%2891%2991705-Y\" aria-label=\"Article reference 10\" data-doi=\"10.1016\/0140-6736(91)91705-Y\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaK3M3htFGjtg%3D%3D\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1673491\" aria-label=\"PubMed reference 10\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clustering%20of%20features%20of%20von%20Hippel-Lindau%20syndrome%3A%20evidence%20for%20a%20complex%20genetic%20locus&amp;journal=Lancet&amp;doi=10.1016%2F0140-6736%2891%2991705-Y&amp;volume=337&amp;issue=8749&amp;pages=1052-1054&amp;publication_year=1991&amp;author=Neumann%2CHP&amp;author=Wiestler%2COD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"11.\">\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Neumann HPH, Eggert HR, Scheremet R, Schumacher M, Mohadjer M, Wakhloo AK, et al. Central nervous system lesions in von Hippel-Lindau syndrome. J Neurol Neurosurg Psychiatry. 1992;55:898\u2013901.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1136\/jnnp.55.10.898\" data-track-item_id=\"10.1136\/jnnp.55.10.898\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1136%2Fjnnp.55.10.898\" aria-label=\"Article reference 11\" data-doi=\"10.1136\/jnnp.55.10.898\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaK3s%2FlslGruw%3D%3D\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1431953\" aria-label=\"PubMed reference 11\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1015185\" aria-label=\"PubMed Central reference 11\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20nervous%20system%20lesions%20in%20von%20Hippel-Lindau%20syndrome&amp;journal=J%20Neurol%20Neurosurg%20Psychiatry&amp;doi=10.1136%2Fjnnp.55.10.898&amp;volume=55&amp;pages=898-901&amp;publication_year=1992&amp;author=Neumann%2CHPH&amp;author=Eggert%2CHR&amp;author=Scheremet%2CR&amp;author=Schumacher%2CM&amp;author=Mohadjer%2CM&amp;author=Wakhloo%2CAK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"12.\">\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Chen J, Geng W, Zhao Y, Zhao H, Wang G, Huang F, et al. Clinical and mutation analysis of four Chinese families with von Hippel-Lindau disease. Clin Transl Oncol. 2013;15(5):391\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s12094-012-0940-x\" data-track-item_id=\"10.1007\/s12094-012-0940-x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s12094-012-0940-x\" aria-label=\"Article reference 12\" data-doi=\"10.1007\/s12094-012-0940-x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DC%2BC3s7isFKrtg%3D%3D\" aria-label=\"CAS reference 12\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23143947\" aria-label=\"PubMed reference 12\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clinical%20and%20mutation%20analysis%20of%20four%20Chinese%20families%20with%20von%20Hippel-Lindau%20disease&amp;journal=Clin%20Transl%20Oncol&amp;doi=10.1007%2Fs12094-012-0940-x&amp;volume=15&amp;issue=5&amp;pages=391-397&amp;publication_year=2013&amp;author=Chen%2CJ&amp;author=Geng%2CW&amp;author=Zhao%2CY&amp;author=Zhao%2CH&amp;author=Wang%2CG&amp;author=Huang%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"13.\">\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Binderup MLM, Jensen AM, Budtz-J\u00f8rgensen E, Bisgaard ML. Survival and causes of death in patients with von Hippel-Lindau disease. J Med Genet. 2017;54(1):11\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1136\/jmedgenet-2016-104058\" data-track-item_id=\"10.1136\/jmedgenet-2016-104058\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1136%2Fjmedgenet-2016-104058\" aria-label=\"Article reference 13\" data-doi=\"10.1136\/jmedgenet-2016-104058\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27539272\" aria-label=\"PubMed reference 13\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Survival%20and%20causes%20of%20death%20in%20patients%20with%20von%20Hippel-Lindau%20disease&amp;journal=J%20Med%20Genet&amp;doi=10.1136%2Fjmedgenet-2016-104058&amp;volume=54&amp;issue=1&amp;pages=11-18&amp;publication_year=2017&amp;author=Binderup%2CMLM&amp;author=Jensen%2CAM&amp;author=Budtz-J%C3%B8rgensen%2CE&amp;author=Bisgaard%2CML\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"14.\">\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Maher ER, Yates JRW, Harries R, Benjamin C, Harris R, Moore AT, et al. Clinical features and natural history of von hippel-lindau disease. QJM. 1990;77(2):1151\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/qjmed\/77.2.1151\" data-track-item_id=\"10.1093\/qjmed\/77.2.1151\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fqjmed%2F77.2.1151\" aria-label=\"Article reference 14\" data-doi=\"10.1093\/qjmed\/77.2.1151\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaK3M7htVyksQ%3D%3D\" aria-label=\"CAS reference 14\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2274658\" aria-label=\"PubMed reference 14\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clinical%20features%20and%20natural%20history%20of%20von%20hippel-lindau%20disease&amp;journal=QJM&amp;doi=10.1093%2Fqjmed%2F77.2.1151&amp;volume=77&amp;issue=2&amp;pages=1151-1163&amp;publication_year=1990&amp;author=Maher%2CER&amp;author=Yates%2CJRW&amp;author=Harries%2CR&amp;author=Benjamin%2CC&amp;author=Harris%2CR&amp;author=Moore%2CAT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"15.\">\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Gordeuk VR, Sergueeva AI, Miasnikova GY, Okhotin D, Voloshin Y, Choyke PL, et al. Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors. Blood. 2004;103(10):3924\u201332.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1182\/blood-2003-07-2535\" data-track-item_id=\"10.1182\/blood-2003-07-2535\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1182%2Fblood-2003-07-2535\" aria-label=\"Article reference 15\" data-doi=\"10.1182\/blood-2003-07-2535\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXjvF2hsro%3D\" aria-label=\"CAS reference 15\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=14726398\" aria-label=\"PubMed reference 15\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Congenital%20disorder%20of%20oxygen%20sensing%3A%20association%20of%20the%20homozygous%20Chuvash%20polycythemia%20VHL%20mutation%20with%20thrombosis%20and%20vascular%20abnormalities%20but%20not%20tumors&amp;journal=Blood&amp;doi=10.1182%2Fblood-2003-07-2535&amp;volume=103&amp;issue=10&amp;pages=3924-3932&amp;publication_year=2004&amp;author=Gordeuk%2CVR&amp;author=Sergueeva%2CAI&amp;author=Miasnikova%2CGY&amp;author=Okhotin%2CD&amp;author=Voloshin%2CY&amp;author=Choyke%2CPL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"16.\">\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Perrotta S, Roberti D, Bencivenga D, Corsetto P, O\u2019Brien KA, Caiazza M, et al. Effects of germline VHL deficiency on growth, metabolism, and mitochondria. N Engl J Med. 2020;382(9):835\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1056\/NEJMoa1907362\" data-track-item_id=\"10.1056\/NEJMoa1907362\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1056%2FNEJMoa1907362\" aria-label=\"Article reference 16\" data-doi=\"10.1056\/NEJMoa1907362\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXpvFOjur0%3D\" aria-label=\"CAS reference 16\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32101665\" aria-label=\"PubMed reference 16\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20germline%20VHL%20deficiency%20on%20growth%2C%20metabolism%2C%20and%20mitochondria&amp;journal=N%20Engl%20J%20Med&amp;doi=10.1056%2FNEJMoa1907362&amp;volume=382&amp;issue=9&amp;pages=835-844&amp;publication_year=2020&amp;author=Perrotta%2CS&amp;author=Roberti%2CD&amp;author=Bencivenga%2CD&amp;author=Corsetto%2CP&amp;author=O%E2%80%99Brien%2CKA&amp;author=Caiazza%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"17.\">\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Flores SK, Cheng Z, Jasper AM, Natori K, Okamoto T, Tanabe A, et al. A synonymous VHL variant in exon 2 confers susceptibility to familial pheochromocytoma and von Hippel-Lindau disease. J Clin Endocrinol Metab. 2019;104(9):3826\u201334.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1210\/jc.2019-00235\" data-track-item_id=\"10.1210\/jc.2019-00235\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1210%2Fjc.2019-00235\" aria-label=\"Article reference 17\" data-doi=\"10.1210\/jc.2019-00235\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30946460\" aria-label=\"PubMed reference 17\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6660912\" aria-label=\"PubMed Central reference 17\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20synonymous%20VHL%20variant%20in%20exon%202%20confers%20susceptibility%20to%20familial%20pheochromocytoma%20and%20von%20Hippel-Lindau%20disease&amp;journal=J%20Clin%20Endocrinol%20Metab&amp;doi=10.1210%2Fjc.2019-00235&amp;volume=104&amp;issue=9&amp;pages=3826-3834&amp;publication_year=2019&amp;author=Flores%2CSK&amp;author=Cheng%2CZ&amp;author=Jasper%2CAM&amp;author=Natori%2CK&amp;author=Okamoto%2CT&amp;author=Tanabe%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"18.\">\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Lenglet M, Robriquet F, Schwarz K, Camps C, Couturier A, Hoogewijs D, et al. Identification of a new VHL exon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease. Blood. 2018;132(5):469\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1182\/blood-2018-03-838235\" data-track-item_id=\"10.1182\/blood-2018-03-838235\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1182%2Fblood-2018-03-838235\" aria-label=\"Article reference 18\" data-doi=\"10.1182\/blood-2018-03-838235\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXitVSnsbzP\" aria-label=\"CAS reference 18\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29891534\" aria-label=\"PubMed reference 18\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Identification%20of%20a%20new%20VHL%20exon%20and%20complex%20splicing%20alterations%20in%20familial%20erythrocytosis%20or%20von%20Hippel-Lindau%20disease&amp;journal=Blood&amp;doi=10.1182%2Fblood-2018-03-838235&amp;volume=132&amp;issue=5&amp;pages=469-483&amp;publication_year=2018&amp;author=Lenglet%2CM&amp;author=Robriquet%2CF&amp;author=Schwarz%2CK&amp;author=Camps%2CC&amp;author=Couturier%2CA&amp;author=Hoogewijs%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"19.\">\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3): e1001779.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pmed.1001779\" data-track-item_id=\"10.1371\/journal.pmed.1001779\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pmed.1001779\" aria-label=\"Article reference 19\" data-doi=\"10.1371\/journal.pmed.1001779\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25826379\" aria-label=\"PubMed reference 19\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4380465\" aria-label=\"PubMed Central reference 19\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=UK%20Biobank%3A%20an%20open%20access%20resource%20for%20identifying%20the%20causes%20of%20a%20wide%20range%20of%20complex%20diseases%20of%20middle%20and%20old%20age&amp;journal=PLoS%20Med&amp;doi=10.1371%2Fjournal.pmed.1001779&amp;volume=12&amp;issue=3&amp;publication_year=2015&amp;author=Sudlow%2CC&amp;author=Gallacher%2CJ&amp;author=Allen%2CN&amp;author=Beral%2CV&amp;author=Burton%2CP&amp;author=Danesh%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"20.\">\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the Association for molecular pathology. Genet Med. 2015;17(5):405\u201324.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/gim.2015.30\" data-track-item_id=\"10.1038\/gim.2015.30\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fgim.2015.30\" aria-label=\"Article reference 20\" data-doi=\"10.1038\/gim.2015.30\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25741868\" aria-label=\"PubMed reference 20\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4544753\" aria-label=\"PubMed Central reference 20\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Standards%20and%20guidelines%20for%20the%20interpretation%20of%20sequence%20variants%3A%20a%20joint%20consensus%20recommendation%20of%20the%20American%20college%20of%20medical%20genetics%20and%20genomics%20and%20the%20Association%20for%20molecular%20pathology&amp;journal=Genet%20Med&amp;doi=10.1038%2Fgim.2015.30&amp;volume=17&amp;issue=5&amp;pages=405-424&amp;publication_year=2015&amp;author=Richards%2CS&amp;author=Aziz%2CN&amp;author=Bale%2CS&amp;author=Bick%2CD&amp;author=Das%2CS&amp;author=Gastier-Foster%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"21.\">\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Tirosh A, Sadowski SM, Linehan WM, Libutti SK, Patel D, Nilubol N, et al. Association of VHL genotype with pancreatic neuroendocrine tumor phenotype in patients with von hippel-lindau disease. JAMA Oncol. 2018;4(1):124\u20136.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jamaoncol.2017.3428\" data-track-item_id=\"10.1001\/jamaoncol.2017.3428\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjamaoncol.2017.3428\" aria-label=\"Article reference 21\" data-doi=\"10.1001\/jamaoncol.2017.3428\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29075773\" aria-label=\"PubMed reference 21\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20VHL%20genotype%20with%20pancreatic%20neuroendocrine%20tumor%20phenotype%20in%20patients%20with%20von%20hippel-lindau%20disease&amp;journal=JAMA%20Oncol&amp;doi=10.1001%2Fjamaoncol.2017.3428&amp;volume=4&amp;issue=1&amp;pages=124-126&amp;publication_year=2018&amp;author=Tirosh%2CA&amp;author=Sadowski%2CSM&amp;author=Linehan%2CWM&amp;author=Libutti%2CSK&amp;author=Patel%2CD&amp;author=Nilubol%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"22.\">\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Mougel G, Mohamed A, Burnichon N, Giraud S, Pigny P, Bressac-de Paillerets B, et al. Update of the UMD-VHL database: classification of 164 challenging variants based on genotype-phenotype correlation among 605 entries. J Med Genet. 2024;61(4):378\u201384.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1136\/jmg-2023-109550\" data-track-item_id=\"10.1136\/jmg-2023-109550\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1136%2Fjmg-2023-109550\" aria-label=\"Article reference 22\" data-doi=\"10.1136\/jmg-2023-109550\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhsVWnu7fP\" aria-label=\"CAS reference 22\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37979962\" aria-label=\"PubMed reference 22\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Update%20of%20the%20UMD-VHL%20database%3A%20classification%20of%20164%20challenging%20variants%20based%20on%20genotype-phenotype%20correlation%20among%20605%20entries&amp;journal=J%20Med%20Genet&amp;doi=10.1136%2Fjmg-2023-109550&amp;volume=61&amp;issue=4&amp;pages=378-384&amp;publication_year=2024&amp;author=Mougel%2CG&amp;author=Mohamed%2CA&amp;author=Burnichon%2CN&amp;author=Giraud%2CS&amp;author=Pigny%2CP&amp;author=Bressac-de%20Paillerets%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"23.\">\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Ou J, Zhu LJ. trackViewer: a Bioconductor package for interactive and integrative visualization of multi-omics data. Nat Methods. 2019;16(6):453\u20134.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41592-019-0430-y\" data-track-item_id=\"10.1038\/s41592-019-0430-y\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41592-019-0430-y\" aria-label=\"Article reference 23\" data-doi=\"10.1038\/s41592-019-0430-y\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtVCitL3J\" aria-label=\"CAS reference 23\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31133757\" aria-label=\"PubMed reference 23\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=trackViewer%3A%20a%20Bioconductor%20package%20for%20interactive%20and%20integrative%20visualization%20of%20multi-omics%20data&amp;journal=Nat%20Methods&amp;doi=10.1038%2Fs41592-019-0430-y&amp;volume=16&amp;issue=6&amp;pages=453-454&amp;publication_year=2019&amp;author=Ou%2CJ&amp;author=Zhu%2CLJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"24.\">\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Klimentidis YC, Arora A, Newell M, Zhou J, Ordovas JM, Renquist BJ, et al. Phenotypic and genetic characterization of lower LDL cholesterol and increased type 2 diabetes risk in the UK biobank. Diabetes. 2020;69(10):2194\u2013205.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.2337\/db19-1134\" data-track-item_id=\"10.2337\/db19-1134\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.2337%2Fdb19-1134\" aria-label=\"Article reference 24\" data-doi=\"10.2337\/db19-1134\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXit1CgtL3F\" aria-label=\"CAS reference 24\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32493714\" aria-label=\"PubMed reference 24\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7506834\" aria-label=\"PubMed Central reference 24\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Phenotypic%20and%20genetic%20characterization%20of%20lower%20LDL%20cholesterol%20and%20increased%20type%202%20diabetes%20risk%20in%20the%20UK%20biobank&amp;journal=Diabetes&amp;doi=10.2337%2Fdb19-1134&amp;volume=69&amp;issue=10&amp;pages=2194-2205&amp;publication_year=2020&amp;author=Klimentidis%2CYC&amp;author=Arora%2CA&amp;author=Newell%2CM&amp;author=Zhou%2CJ&amp;author=Ordovas%2CJM&amp;author=Renquist%2CBJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"25.\">\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Iliopoulos O, Levy AP, Jiang C, Kaelin WGJ, Goldberg MA. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A. 1996;93(20):10595\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1073\/pnas.93.20.10595\" data-track-item_id=\"10.1073\/pnas.93.20.10595\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1073%2Fpnas.93.20.10595\" aria-label=\"Article reference 25\" data-doi=\"10.1073\/pnas.93.20.10595\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK28XmtVOlsb4%3D\" aria-label=\"CAS reference 25\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8855223\" aria-label=\"PubMed reference 25\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC38198\" aria-label=\"PubMed Central reference 25\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Negative%20regulation%20of%20hypoxia-inducible%20genes%20by%20the%20von%20Hippel-Lindau%20protein&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;doi=10.1073%2Fpnas.93.20.10595&amp;volume=93&amp;issue=20&amp;pages=10595-10599&amp;publication_year=1996&amp;author=Iliopoulos%2CO&amp;author=Levy%2CAP&amp;author=Jiang%2CC&amp;author=Kaelin%2CWGJ&amp;author=Goldberg%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"26.\">\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, et al. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev. 2008;22(22):3135\u201346.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1101\/gad.496908\" data-track-item_id=\"10.1101\/gad.496908\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1101%2Fgad.496908\" aria-label=\"Article reference 26\" data-doi=\"10.1101\/gad.496908\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhsVKhs7%2FI\" aria-label=\"CAS reference 26\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19056893\" aria-label=\"PubMed reference 26\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2593613\" aria-label=\"PubMed Central reference 26\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=PVHL%20is%20a%20regulator%20of%20glucose%20metabolism%20and%20insulin%20secretion%20in%20pancreatic%20beta%20cells&amp;journal=Genes%20Dev&amp;doi=10.1101%2Fgad.496908&amp;volume=22&amp;issue=22&amp;pages=3135-3146&amp;publication_year=2008&amp;author=Zehetner%2CJ&amp;author=Danzer%2CC&amp;author=Collins%2CS&amp;author=Eckhardt%2CK&amp;author=Gerber%2CPA&amp;author=Ballschmieter%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"27.\">\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Puri S, Cano DA, Hebrok M. A role for von Hippel-Lindau protein in pancreatic beta-cell function. Diabetes. 2009;58(2):433\u201341.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.2337\/db08-0749\" data-track-item_id=\"10.2337\/db08-0749\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.2337%2Fdb08-0749\" aria-label=\"Article reference 27\" data-doi=\"10.2337\/db08-0749\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhslersbc%3D\" aria-label=\"CAS reference 27\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19033400\" aria-label=\"PubMed reference 27\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2628617\" aria-label=\"PubMed Central reference 27\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20role%20for%20von%20Hippel-Lindau%20protein%20in%20pancreatic%20beta-cell%20function&amp;journal=Diabetes&amp;doi=10.2337%2Fdb08-0749&amp;volume=58&amp;issue=2&amp;pages=433-441&amp;publication_year=2009&amp;author=Puri%2CS&amp;author=Cano%2CDA&amp;author=Hebrok%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"28.\">\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, et al. Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest. 2009;119(1):125\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXmtFChtQ%3D%3D\" aria-label=\"CAS reference 28\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19065050\" aria-label=\"PubMed reference 28\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Deletion%20of%20the%20von%20Hippel-Lindau%20gene%20in%20pancreatic%20beta%20cells%20impairs%20glucose%20homeostasis%20in%20mice&amp;journal=J%20Clin%20Invest&amp;volume=119&amp;issue=1&amp;pages=125-135&amp;publication_year=2009&amp;author=Cantley%2CJ&amp;author=Selman%2CC&amp;author=Shukla%2CD&amp;author=Abramov%2CAY&amp;author=Forstreuter%2CF&amp;author=Esteban%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"29.\">\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Ilegems E, Bryzgalova G, Correia J, Yesildag B, Berra E, Ruas JL, et al. HIF-1\u03b1 inhibitor PX-478 preserves pancreatic \u03b2 cell function in diabetes. Sci Transl Med. 2022;14(638):eaba9112.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/scitranslmed.aba9112\" data-track-item_id=\"10.1126\/scitranslmed.aba9112\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscitranslmed.aba9112\" aria-label=\"Article reference 29\" data-doi=\"10.1126\/scitranslmed.aba9112\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XpvVymsrY%3D\" aria-label=\"CAS reference 29\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35353540\" aria-label=\"PubMed reference 29\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=HIF-1%CE%B1%20inhibitor%20PX-478%20preserves%20pancreatic%20%CE%B2%20cell%20function%20in%20diabetes&amp;journal=Sci%20Transl%20Med.&amp;doi=10.1126%2Fscitranslmed.aba9112&amp;volume=14&amp;issue=638&amp;publication_year=2022&amp;author=Ilegems%2CE&amp;author=Bryzgalova%2CG&amp;author=Correia%2CJ&amp;author=Yesildag%2CB&amp;author=Berra%2CE&amp;author=Ruas%2CJL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"30.\">\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Ryczek N, \u0141y\u015b A, Maka\u0142owska I. The functional meaning of 5\u2019UTR in protein-coding genes. Int J Mol Sci. 2023;24(3):2976.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms24032976\" data-track-item_id=\"10.3390\/ijms24032976\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms24032976\" aria-label=\"Article reference 30\" data-doi=\"10.3390\/ijms24032976\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXjsFagt78%3D\" aria-label=\"CAS reference 30\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36769304\" aria-label=\"PubMed reference 30\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9917990\" aria-label=\"PubMed Central reference 30\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20functional%20meaning%20of%205%E2%80%99UTR%20in%20protein-coding%20genes&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms24032976&amp;volume=24&amp;issue=3&amp;publication_year=2023&amp;author=Ryczek%2CN&amp;author=%C5%81y%C5%9B%2CA&amp;author=Maka%C5%82owska%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"31.\">\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Tamura K, Kanazashi Y, Kawada C, Sekine Y, Maejima K, Ashida S, et al. Variant spectrum of von Hippel-Lindau disease and its genomic heterogeneity in Japan. Hum Mol Genet. 2023;32(12):2046\u201354.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/hmg\/ddad039\" data-track-item_id=\"10.1093\/hmg\/ddad039\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fhmg%2Fddad039\" aria-label=\"Article reference 31\" data-doi=\"10.1093\/hmg\/ddad039\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitlansrrE\" aria-label=\"CAS reference 31\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36905328\" aria-label=\"PubMed reference 31\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10244221\" aria-label=\"PubMed Central reference 31\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Variant%20spectrum%20of%20von%20Hippel-Lindau%20disease%20and%20its%20genomic%20heterogeneity%20in%20Japan&amp;journal=Hum%20Mol%20Genet&amp;doi=10.1093%2Fhmg%2Fddad039&amp;volume=32&amp;issue=12&amp;pages=2046-2054&amp;publication_year=2023&amp;author=Tamura%2CK&amp;author=Kanazashi%2CY&amp;author=Kawada%2CC&amp;author=Sekine%2CY&amp;author=Maejima%2CK&amp;author=Ashida%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"32.\">\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Chiorean A, Farncombe KM, Delong S, Andric V, Ansar S, Chan C, et al. Large scale genotype- and phenotype-driven machine learning in Von Hippel-Lindau disease. Hum Mutat. 2022;43(9):1268\u201385.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/humu.24392\" data-track-item_id=\"10.1002\/humu.24392\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fhumu.24392\" aria-label=\"Article reference 32\" data-doi=\"10.1002\/humu.24392\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhvVGnsrfJ\" aria-label=\"CAS reference 32\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35475554\" aria-label=\"PubMed reference 32\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Large%20scale%20genotype-%20and%20phenotype-driven%20machine%20learning%20in%20Von%20Hippel-Lindau%20disease&amp;journal=Hum%20Mutat&amp;doi=10.1002%2Fhumu.24392&amp;volume=43&amp;issue=9&amp;pages=1268-1285&amp;publication_year=2022&amp;author=Chiorean%2CA&amp;author=Farncombe%2CKM&amp;author=Delong%2CS&amp;author=Andric%2CV&amp;author=Ansar%2CS&amp;author=Chan%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"33.\">\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Mohebian K, Hesse D, Arends D, Brockmann GA. A 5\u2019 UTR mutation contributes to down-regulation of Bbs7 in the Berlin fat mouse. Int J Mol Sci. 2022;23(21):13018.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms232113018\" data-track-item_id=\"10.3390\/ijms232113018\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms232113018\" aria-label=\"Article reference 33\" data-doi=\"10.3390\/ijms232113018\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XivV2mt7zN\" aria-label=\"CAS reference 33\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36361806\" aria-label=\"PubMed reference 33\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9658298\" aria-label=\"PubMed Central reference 33\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%205%E2%80%99%20UTR%20mutation%20contributes%20to%20down-regulation%20of%20Bbs7%20in%20the%20Berlin%20fat%20mouse&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms232113018&amp;volume=23&amp;issue=21&amp;publication_year=2022&amp;author=Mohebian%2CK&amp;author=Hesse%2CD&amp;author=Arends%2CD&amp;author=Brockmann%2CGA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"34.\">\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres Diz M, Xu F, et al. Alternative splicing of its 5\u2019-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. Blood. 2023;142(20):1724\u201339.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1182\/blood.2023020400\" data-track-item_id=\"10.1182\/blood.2023020400\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1182%2Fblood.2023020400\" aria-label=\"Article reference 34\" data-doi=\"10.1182\/blood.2023020400\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitl2ntr%2FK\" aria-label=\"CAS reference 34\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37683180\" aria-label=\"PubMed reference 34\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10667349\" aria-label=\"PubMed Central reference 34\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Alternative%20splicing%20of%20its%205%E2%80%99-UTR%20limits%20CD20%20mRNA%20translation%20and%20enables%20resistance%20to%20CD20-directed%20immunotherapies&amp;journal=Blood&amp;doi=10.1182%2Fblood.2023020400&amp;volume=142&amp;issue=20&amp;pages=1724-1739&amp;publication_year=2023&amp;author=Ang%2CZ&amp;author=Paruzzo%2CL&amp;author=Hayer%2CKE&amp;author=Schmidt%2CC&amp;author=Torres%20Diz%2CM&amp;author=Xu%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"35.\">\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, et al. Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia. Vol. 102, Haematologica. Italy; 2017. p. e166\u20139.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"36.\">\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Lorenzo FR, Yang C, Lanikova L, Butros L, Zhuang Z, Prchal JT. Novel compound VHL heterozygosity (VHL T124A\/L188V) associated with congenital polycythaemia. Vol. 162, British journal of haematology. England; 2013. p. 851\u20133.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"37.\">\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Chomette L, Migeotte I, Dewachter C, Vachiery JL, Smits G, Bondue A. Early-onset and severe pulmonary arterial hypertension due to a novel compound heterozygous association of rare VHL mutations: A case report and review of existing data. Vol. 12, Pulmonary circulation. United States; 2022. p. e12052.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"38.\">\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Gl\u00e4sker S, Sohn TS, Okamoto H, Li J, Lonser RR, Oldfield EH, et al. Second hit deletion size in von Hippel-Lindau disease. Ann Neurol. 2006;59(1):105\u201310.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/ana.20704\" data-track-item_id=\"10.1002\/ana.20704\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fana.20704\" aria-label=\"Article reference 38\" data-doi=\"10.1002\/ana.20704\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16261628\" aria-label=\"PubMed reference 38\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Second%20hit%20deletion%20size%20in%20von%20Hippel-Lindau%20disease&amp;journal=Ann%20Neurol&amp;doi=10.1002%2Fana.20704&amp;volume=59&amp;issue=1&amp;pages=105-110&amp;publication_year=2006&amp;author=Gl%C3%A4sker%2CS&amp;author=Sohn%2CTS&amp;author=Okamoto%2CH&amp;author=Li%2CJ&amp;author=Lonser%2CRR&amp;author=Oldfield%2CEH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"39.\">\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Menendez-Montes I, Escobar B, Palacios B, G\u00f3mez MJ, Izquierdo-Garcia JL, Flores L, et al. Myocardial VHL-HIF signaling controls an embryonic metabolic switch essential for cardiac maturation. Dev Cell. 2016;39(6):724\u201339.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.devcel.2016.11.012\" data-track-item_id=\"10.1016\/j.devcel.2016.11.012\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.devcel.2016.11.012\" aria-label=\"Article reference 39\" data-doi=\"10.1016\/j.devcel.2016.11.012\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XitFaht7vF\" aria-label=\"CAS reference 39\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27997827\" aria-label=\"PubMed reference 39\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Myocardial%20VHL-HIF%20signaling%20controls%20an%20embryonic%20metabolic%20switch%20essential%20for%20cardiac%20maturation&amp;journal=Dev%20Cell&amp;doi=10.1016%2Fj.devcel.2016.11.012&amp;volume=39&amp;issue=6&amp;pages=724-739&amp;publication_year=2016&amp;author=Menendez-Montes%2CI&amp;author=Escobar%2CB&amp;author=Palacios%2CB&amp;author=G%C3%B3mez%2CMJ&amp;author=Izquierdo-Garcia%2CJL&amp;author=Flores%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"40.\">\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Song SH, Kim JH, Lee JH, Yun YM, Choi DH, Kim HY. Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke. BMC Neurol. 2017;17(1):20.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1186\/s12883-017-0808-3\" data-track-item_id=\"10.1186\/s12883-017-0808-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12883-017-0808-3\" aria-label=\"Article reference 40\" data-doi=\"10.1186\/s12883-017-0808-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28143595\" aria-label=\"PubMed reference 40\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5282628\" aria-label=\"PubMed Central reference 40\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Elevated%20blood%20viscosity%20is%20associated%20with%20cerebral%20small%20vessel%20disease%20in%20patients%20with%20acute%20ischemic%20stroke&amp;journal=BMC%20Neurol&amp;doi=10.1186%2Fs12883-017-0808-3&amp;volume=17&amp;issue=1&amp;publication_year=2017&amp;author=Song%2CSH&amp;author=Kim%2CJH&amp;author=Lee%2CJH&amp;author=Yun%2CYM&amp;author=Choi%2CDH&amp;author=Kim%2CHY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"41.\">\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Woo HG, Kim HG, Lee KM, Ha SH, Jo H, Heo SH, et al. Blood viscosity associated with stroke mechanism and early neurological deterioration in middle cerebral artery atherosclerosis. Sci Rep. 2023;13(1):9384.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41598-023-36633-z\" data-track-item_id=\"10.1038\/s41598-023-36633-z\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41598-023-36633-z\" aria-label=\"Article reference 41\" data-doi=\"10.1038\/s41598-023-36633-z\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXht1amurbP\" aria-label=\"CAS reference 41\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37296267\" aria-label=\"PubMed reference 41\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10256783\" aria-label=\"PubMed Central reference 41\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Blood%20viscosity%20associated%20with%20stroke%20mechanism%20and%20early%20neurological%20deterioration%20in%20middle%20cerebral%20artery%20atherosclerosis&amp;journal=Sci%20Rep&amp;doi=10.1038%2Fs41598-023-36633-z&amp;volume=13&amp;issue=1&amp;publication_year=2023&amp;author=Woo%2CHG&amp;author=Kim%2CHG&amp;author=Lee%2CKM&amp;author=Ha%2CSH&amp;author=Jo%2CH&amp;author=Heo%2CSH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"42.\">\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Savatt JM, Kelly MA, Sturm AC, McCormick CZ, Williams MS, Nixon MP, et al. Genomic screening at a single health system. JAMA Netw Open. 2025;8(3): e250917.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jamanetworkopen.2025.0917\" data-track-item_id=\"10.1001\/jamanetworkopen.2025.0917\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjamanetworkopen.2025.0917\" aria-label=\"Article reference 42\" data-doi=\"10.1001\/jamanetworkopen.2025.0917\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40094662\" aria-label=\"PubMed reference 42\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11915069\" aria-label=\"PubMed Central reference 42\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genomic%20screening%20at%20a%20single%20health%20system&amp;journal=JAMA%20Netw%20Open&amp;doi=10.1001%2Fjamanetworkopen.2025.0917&amp;volume=8&amp;issue=3&amp;publication_year=2025&amp;author=Savatt%2CJM&amp;author=Kelly%2CMA&amp;author=Sturm%2CAC&amp;author=McCormick%2CCZ&amp;author=Williams%2CMS&amp;author=Nixon%2CMP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"43.\">\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Sun Y, Yu Y, Cai L, Yu B, Xiao W, Tan X, et al. Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study. Cardiovasc Diabetol. 2025;24(1):72.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1186\/s12933-025-02626-7\" data-track-item_id=\"10.1186\/s12933-025-02626-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12933-025-02626-7\" aria-label=\"Article reference 43\" data-doi=\"10.1186\/s12933-025-02626-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXktFSitr8%3D\" aria-label=\"CAS reference 43\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39948662\" aria-label=\"PubMed reference 43\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11827465\" aria-label=\"PubMed Central reference 43\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clonal%20hematopoiesis%20of%20indeterminate%20potential%2C%20health%20indicators%2C%20and%20risk%20of%20cardiovascular%20diseases%20among%20patients%20with%20diabetes%3A%20a%20prospective%20cohort%20study&amp;journal=Cardiovasc%20Diabetol&amp;doi=10.1186%2Fs12933-025-02626-7&amp;volume=24&amp;issue=1&amp;publication_year=2025&amp;author=Sun%2CY&amp;author=Yu%2CY&amp;author=Cai%2CL&amp;author=Yu%2CB&amp;author=Xiao%2CW&amp;author=Tan%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"44.\">\n<p class=\"c-article-references__text\" id=\"ref-CR44\">CDC Summary health statistics [Internet]. Available from: <a href=\"https:\/\/www.cdc.gov\/nchs\/nhis\/shs\/tables.htm\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"https:\/\/www.cdc.gov\/nchs\/nhis\/shs\/tables.htm\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cdc.gov\/nchs\/nhis\/shs\/tables.htm<\/a><\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"45.\">\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Ding L, Fan Y, Wang J, Ma X, Chang L, He Q, et al. Central lean mass distribution and the risks of all-cause and cause-specific mortality in 40,283 UK Biobank participants. Obes Facts. 2024;17(5):502\u201312.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1159\/000540219\" data-track-item_id=\"10.1159\/000540219\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1159%2F000540219\" aria-label=\"Article reference 45\" data-doi=\"10.1159\/000540219\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39047689\" aria-label=\"PubMed reference 45\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11458161\" aria-label=\"PubMed Central reference 45\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20lean%20mass%20distribution%20and%20the%20risks%20of%20all-cause%20and%20cause-specific%20mortality%20in%2040%2C283%20UK%20Biobank%20participants&amp;journal=Obes%20Facts&amp;doi=10.1159%2F000540219&amp;volume=17&amp;issue=5&amp;pages=502-512&amp;publication_year=2024&amp;author=Ding%2CL&amp;author=Fan%2CY&amp;author=Wang%2CJ&amp;author=Ma%2CX&amp;author=Chang%2CL&amp;author=He%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"46.\">\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Cheung Q, Wharton S, Josse A, Kuk JL. Ethnic variations in cardiovascular disease (CVD) risk factors and associations with prevalent CVD and CVD mortality in the United States. PLoS ONE. 2025;20(3): e0319617.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pone.0319617\" data-track-item_id=\"10.1371\/journal.pone.0319617\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pone.0319617\" aria-label=\"Article reference 46\" data-doi=\"10.1371\/journal.pone.0319617\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXnvFOks70%3D\" aria-label=\"CAS reference 46\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40138291\" aria-label=\"PubMed reference 46\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11940680\" aria-label=\"PubMed Central reference 46\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ethnic%20variations%20in%20cardiovascular%20disease%20%28CVD%29%20risk%20factors%20and%20associations%20with%20prevalent%20CVD%20and%20CVD%20mortality%20in%20the%20United%20States&amp;journal=PLoS%20ONE&amp;doi=10.1371%2Fjournal.pone.0319617&amp;volume=20&amp;issue=3&amp;publication_year=2025&amp;author=Cheung%2CQ&amp;author=Wharton%2CS&amp;author=Josse%2CA&amp;author=Kuk%2CJL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"47.\">\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Joseph JJ, Ortiz R, Acharya T, Golden SH, L\u00f3pez L, Deedwania P. Cardiovascular impact of race and ethnicity in patients with diabetes and obesity: JACC focus seminar 2\/9. J Am Coll Cardiol. 2021;78(24):2471\u201382.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jacc.2021.06.020\" data-track-item_id=\"10.1016\/j.jacc.2021.06.020\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jacc.2021.06.020\" aria-label=\"Article reference 47\" data-doi=\"10.1016\/j.jacc.2021.06.020\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34886969\" aria-label=\"PubMed reference 47\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cardiovascular%20impact%20of%20race%20and%20ethnicity%20in%20patients%20with%20diabetes%20and%20obesity%3A%20JACC%20focus%20seminar%202%2F9&amp;journal=J%20Am%20Coll%20Cardiol&amp;doi=10.1016%2Fj.jacc.2021.06.020&amp;volume=78&amp;issue=24&amp;pages=2471-2482&amp;publication_year=2021&amp;author=Joseph%2CJJ&amp;author=Ortiz%2CR&amp;author=Acharya%2CT&amp;author=Golden%2CSH&amp;author=L%C3%B3pez%2CL&amp;author=Deedwania%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"48.\">\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Mital R, Bayne J, Rodriguez F, Ovbiagele B, Bhatt DL, Albert MA. Race and ethnicity considerations in patients with coronary artery disease and stroke: JACC focus seminar 3\/9. J Am Coll Cardiol. 2021;78(24):2483\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jacc.2021.05.051\" data-track-item_id=\"10.1016\/j.jacc.2021.05.051\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jacc.2021.05.051\" aria-label=\"Article reference 48\" data-doi=\"10.1016\/j.jacc.2021.05.051\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34886970\" aria-label=\"PubMed reference 48\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Race%20and%20ethnicity%20considerations%20in%20patients%20with%20coronary%20artery%20disease%20and%20stroke%3A%20JACC%20focus%20seminar%203%2F9&amp;journal=J%20Am%20Coll%20Cardiol&amp;doi=10.1016%2Fj.jacc.2021.05.051&amp;volume=78&amp;issue=24&amp;pages=2483-2492&amp;publication_year=2021&amp;author=Mital%2CR&amp;author=Bayne%2CJ&amp;author=Rodriguez%2CF&amp;author=Ovbiagele%2CB&amp;author=Bhatt%2CDL&amp;author=Albert%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"Buckley M, Terwagne C, Ganner A, Cubitt L, Brewer R, Kim DK, et al. Saturation genome editing maps&hellip;\n","protected":false},"author":2,"featured_media":158866,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[67195,6441,9772,67194,967,267,70,16,30615,15,67193],"class_list":{"0":"post-158865","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-angiology","9":"tag-cardiology","10":"tag-cardiovascular-risk","11":"tag-cerebrovascular-accident","12":"tag-diabetes","13":"tag-genetics","14":"tag-science","15":"tag-uk","16":"tag-uk-biobank","17":"tag-united-kingdom","18":"tag-von-hippel-lindau"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114627945666611688","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/158865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=158865"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/158865\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/158866"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=158865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=158865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=158865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}