![\"Researchers](\"https:\/\/media.ahmedabadmirror.com\/am\/uploads\/mediaGallery\/image\/1744392337962.jpg-org\")
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Array Researchers develop new genetic method that turns tumour-supporting cells into killers => Researchers develop new genetic method that turns tumour-supporting cells into killers<\/p>\n IANS<\/p>\n Apr 12, 2025 03:00 PM | UPDATED: Apr 11, 2025 10:56 PM | 10 min read<\/p>\n A team of researchers from Israel, the US, and China has developed a genetic method to reprogram a type of immune cell, turning them from cancer promoters to inhibitors. The team, led by Israel\u2019s Weizmann Institute of Science, focused on macrophages \u2014 a type of immune cell that can induce immune responses. But in many cancers, macrophages become allies that protect the tumour, help it grow, and even aid in spreading it to other tissues, Xinhua news agency reported. Using advanced gene-editing tools and artificial intelligence, the researchers analysed human tumour samples and identified 120 genes potentially responsible for the transformation. \u00a0<\/p>\n \u201cMacrophages are highly versatile cells, sort of a \u2018Swiss knife\u2019 of the immune system, capable of activating multiple types of functions for different tasks and in different situations,\u201d said Professor Ido Amit, a faculty member of Weizmann\u2019s Systems Immunology Department. These cells can potentially be highly effective cancer eradicators that can perform multiple antitumor functions, such as promoting anticancer inflammation or alerting the rest of the immune system to the dangers posed by tumour cells. That\u2019s precisely the reason most solid cancers need to convert macrophages to their side to develop. \u201cBy doing that, the tumours protect themselves from the macrophages\u2019 \u2018nasty\u2019 side, and also turn on macrophage functions that help them grow, such as suppressing the activity of other immune cell types and encouraging blood vessel growth for supplying oxygen to the tumour,\u201d Amit added.\u00a0<\/p>\n Through CRISPR-Cas9 gene editing and single-cell analysis, they zeroed in on a gene named Zeb2.\u00a0<\/p>\n The researchers found that Zeb2 acts as a master switch. When the gene is active, it turns macrophages into cancer supporters. When silenced, macrophages revert to their natural, cancer-fighting role. Further studies showed Zeb2 alters the epigenome \u2014 the genome\u2019s control centre \u2014 unlocking genes that help cancer and shutting down those that fight it. The team designed a DNA molecule that delivers a gene-silencing agent directly into macrophages. In mice with bladder cancer, injecting the molecule into the tumour successfully reprogrammed the macrophages. The tumours got significantly smaller. \u00a0IANS<\/p>\n","protected":false},"excerpt":{"rendered":"Others You Array ( [galleryId] => 85394f2e61cc27799d6da6850221b97738b8f2e662fbf9ee [thumbImage] => https:\/\/media.ahmedabadmirror.com\/am\/uploads\/mediaGallery\/image\/1744392337962.jpg-thmb [largeImage] => https:\/\/media.ahmedabadmirror.com\/am\/uploads\/mediaGallery\/image\/1744392337962.jpg-sldr [fullImage] => https:\/\/media.ahmedabadmirror.com\/am\/uploads\/mediaGallery\/image\/1744392337962.jpg-org [videoObj] =>…\n","protected":false},"author":2,"featured_media":17494,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[11429,77,267,70,11430,16,15],"class_list":{"0":"post-17493","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-ahmedabad-news-with-photos-and-videos-get-all-latest-and-breaking-ahmedabad-news-here-includes-current-affairs","9":"tag-entertainment","10":"tag-genetics","11":"tag-science","12":"tag-sports-ahmedabad-city-news-online","13":"tag-uk","14":"tag-united-kingdom"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/17493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=17493"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/17493\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/17494"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=17493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=17493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=17493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n Researchers develop new genetic method that turns tumour-supporting cells into killers<\/a> Ahmedabad Mirror<\/font> => Researchers develop new genetic method that turns tumour-supporting cells into killers
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