{"id":176320,"date":"2025-06-11T18:19:07","date_gmt":"2025-06-11T18:19:07","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/176320\/"},"modified":"2025-06-11T18:19:07","modified_gmt":"2025-06-11T18:19:07","slug":"synthetic-biology-encourages-cells-to-keep-on-producing","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/176320\/","title":{"rendered":"Synthetic Biology Encourages Cells to Keep on Producing"},"content":{"rendered":"<p>            <img decoding=\"async\" class=\"object-cover w-full h-full\" src=\"https:\/\/www.europesays.com\/uk\/wp-content\/uploads\/2025\/06\/GettyImages-1727427928.jpg\" alt=\"futuistic dna\"\/><\/p>\n<p class=\"!mb-8 !font-palatino !italic !text-[#767676] !text-[14px] !leading-[21px]\">Credit: Adventtr\/Getty Images&#13;<br \/>\n&#13;\n<\/p>\n<p>A Danish company says they\u2019ve found a way in helping to stop cells from \u201cmicro-evolving\u201d during manufacturing to produce fewer monoclonal antibodies (mAbs). Enduro Genetics, which specializes in synthetic biology, says they\u2019ve developed genetic plugins featuring biosensors and promoters that can detect and regulate mAb production levels in cells.<\/p>\n<p>\u201cThe reason why cells differentiate during a process is because they don\u2019t want to be high producing from an evolutionary perspective,\u201d explains Peter Rugbjerg, PhD, CSO, and founder of Enduro. \u201cWe flipped the problem around to make it to the cell\u2019s advantage to be highly productive, and this drives evolution to become a positive.\u201d<\/p>\n<p>According to Rugbjerg, Enduro\u2019s technology is based on burden-responsive promoters. These act as intracellular biosensors that detect the production level of cells and then use this transcriptional signal to regulate a gene essential to the cell.<\/p>\n<p>Gene regulation changes the composition of available cells to contain more high producers, increasing the average production of the cells overall, he says. The technology can also be used to encourage adaptive evolution, improving cellular performance over a long production run.<\/p>\n<p>Rugbjerg claims that Enduro Genetics is the only company currently taking this approach. \u201cWe started out in 2014 and, through that, secured patent protection,\u201d he notes.<\/p>\n<p>The company spoke at the Bioprocessing Summit Europe. According to Rugbjerg, this was to raise awareness of Enduro and start a conversation within the industry. \u201cIt\u2019s been a long journey to launching a radical new technology,\u201d he tells GEN. \u201cWhen we started out in our research, we had to convince people who told us micro-evolution didn\u2019t happen within the scale of industrial bioprocesses. Now it\u2019s widely accepted.\u201d<\/p>\n<p>Enduro Genetics is now beginning conversations with other companies about how they handle these challenges and is seeking out new opportunities for their technology.<\/p>\n","protected":false},"excerpt":{"rendered":"Credit: Adventtr\/Getty Images&#13; &#13; A Danish company says they\u2019ve found a way in helping to stop cells from&hellip;\n","protected":false},"author":2,"featured_media":176321,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[72856,72857,72861,72858,267,26716,72859,70,72860,11920,16,15],"class_list":{"0":"post-176320","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-bioprocessing","9":"tag-biosensors","10":"tag-enduro-genetics","11":"tag-genetic-transcription","12":"tag-genetics","13":"tag-insights","14":"tag-monoclonal-antibodies","15":"tag-science","16":"tag-synthetic-biotechnology","17":"tag-topics","18":"tag-uk","19":"tag-united-kingdom"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/176320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=176320"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/176320\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/176321"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=176320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=176320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=176320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}