{"id":18501,"date":"2025-04-14T06:10:24","date_gmt":"2025-04-14T06:10:24","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/18501\/"},"modified":"2025-04-14T06:10:24","modified_gmt":"2025-04-14T06:10:24","slug":"sequencing-in-over-50000-cases-identifies-coding-and-structural-variation-underlying-atrial-fibrillation-risk","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/18501\/","title":{"rendered":"Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk"},"content":{"rendered":"<li id=\"Aff1\">\n<p class=\"c-article-author-affiliation__address\">Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Seung Hoan Choi,\u00a0Sean J. Jurgens,\u00a0Ling Xiao,\u00a0Matthew C. Hill,\u00a0Valerie N. Morrill,\u00a0Lu-Chen Weng,\u00a0James P. Pirruccello,\u00a0Helene Mantineo,\u00a0Carolina Roselli,\u00a0Jennifer L. Halford,\u00a0Mark D. Chaffin,\u00a0Victor Nauffal,\u00a0Xin Wang,\u00a0Steven A. Lubitz\u00a0&amp;\u00a0Patrick T. Ellinor<\/p>\n<\/li>\n<li id=\"Aff2\">\n<p class=\"c-article-author-affiliation__address\">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Seung Hoan Choi\u00a0&amp;\u00a0Kathryn L. Lunetta<\/p>\n<\/li>\n<li id=\"Aff3\">\n<p class=\"c-article-author-affiliation__address\">Department of Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences (Heart Failure &amp; Arrhythmias), Amsterdam UMC, Amsterdam, The Netherlands<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sean J. Jurgens\u00a0&amp;\u00a0Connie R. Bezzina<\/p>\n<\/li>\n<li id=\"Aff4\">\n<p class=\"c-article-author-affiliation__address\">Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ling Xiao,\u00a0Matthew C. Hill,\u00a0Lu-Chen Weng,\u00a0James P. Pirruccello,\u00a0Jennifer L. Halford,\u00a0Victor Nauffal,\u00a0Xin Wang,\u00a0Steven A. Lubitz\u00a0&amp;\u00a0Patrick T. Ellinor<\/p>\n<\/li>\n<li id=\"Aff5\">\n<p class=\"c-article-author-affiliation__address\">Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christopher M. Haggerty<\/p>\n<\/li>\n<li id=\"Aff6\">\n<p class=\"c-article-author-affiliation__address\">deCODE genetics\/Amgen, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Gar\u00f0ar Sveinbj\u00f6rnsson,\u00a0David O. Arnar,\u00a0Daniel Fannar Gudbjartsson,\u00a0Hilma Holm\u00a0&amp;\u00a0Kari Stefansson<\/p>\n<\/li>\n<li id=\"Aff7\">\n<p class=\"c-article-author-affiliation__address\">TIMI Study Group, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nicholas A. Marston,\u00a0Christian T. Ruff\u00a0&amp;\u00a0Marc S. Sabatine<\/p>\n<\/li>\n<li id=\"Aff8\">\n<p class=\"c-article-author-affiliation__address\">Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nicholas A. Marston,\u00a0Christian T. Ruff\u00a0&amp;\u00a0Marc S. Sabatine<\/p>\n<\/li>\n<li id=\"Aff9\">\n<p class=\"c-article-author-affiliation__address\">Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">James P. Pirruccello\u00a0&amp;\u00a0Gregory M. Marcus<\/p>\n<\/li>\n<li id=\"Aff10\">\n<p class=\"c-article-author-affiliation__address\">Cardiovascular Center, Landspitali &#8211; The National University Hospital of Iceland, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David O. Arnar<\/p>\n<\/li>\n<li id=\"Aff11\">\n<p class=\"c-article-author-affiliation__address\">Faculty of Medicine, University of Iceland, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David O. Arnar\u00a0&amp;\u00a0Kari Stefansson<\/p>\n<\/li>\n<li id=\"Aff12\">\n<p class=\"c-article-author-affiliation__address\">Faculty of Electical and Computer Engineering and School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Daniel Fannar Gudbjartsson<\/p>\n<\/li>\n<li id=\"Aff13\">\n<p class=\"c-article-author-affiliation__address\">Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Aenne S. von Falkenhausen,\u00a0Moritz F. Sinner\u00a0&amp;\u00a0Stefan Kaab<\/p>\n<\/li>\n<li id=\"Aff14\">\n<p class=\"c-article-author-affiliation__address\">German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Aenne S. von Falkenhausen,\u00a0Moritz F. Sinner\u00a0&amp;\u00a0Stefan Kaab<\/p>\n<\/li>\n<li id=\"Aff15\">\n<p class=\"c-article-author-affiliation__address\">Texas Cardiac Arrhythmia Institute, St David\u2019s Medical Center, Austin, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Andrea Natale\u00a0&amp;\u00a0Sanghamitra Mohanty<\/p>\n<\/li>\n<li id=\"Aff16\">\n<p class=\"c-article-author-affiliation__address\">Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Arnljot Tveit\u00a0&amp;\u00a0Ingrid E. Christophersen<\/p>\n<\/li>\n<li id=\"Aff17\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bastiaan Geelhoed,\u00a0Pim van der Harst\u00a0&amp;\u00a0Michiel Rienstra<\/p>\n<\/li>\n<li id=\"Aff18\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiovascular &amp; Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David R. Van Wagoner\u00a0&amp;\u00a0Jonathan D. Smith<\/p>\n<\/li>\n<li id=\"Aff19\">\n<p class=\"c-article-author-affiliation__address\">Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Dawood Darbar<\/p>\n<\/li>\n<li id=\"Aff20\">\n<p class=\"c-article-author-affiliation__address\">Atrial Fibrillation NETwork (AFNET), M\u00fcnster, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Doreen Haase,\u00a0Renate B. Schnabel\u00a0&amp;\u00a0Paulus Kirchhof<\/p>\n<\/li>\n<li id=\"Aff21\">\n<p class=\"c-article-author-affiliation__address\">Epidemiological Cardiology Research Center (EPICARE), Department of Internal Medicine, Cardiology Section, Wake Forest School of Medicine, Winston-Salem, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Elsayed Z. Soliman<\/p>\n<\/li>\n<li id=\"Aff22\">\n<p class=\"c-article-author-affiliation__address\">Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Giovanni E. Davogustto,\u00a0Quinn S. Wells,\u00a0Zachary T. Yoneda,\u00a0M. Benjamin Shoemaker\u00a0&amp;\u00a0M. Benjamin Shoemaker<\/p>\n<\/li>\n<li id=\"Aff23\">\n<p class=\"c-article-author-affiliation__address\">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Goo Jun<\/p>\n<\/li>\n<li id=\"Aff24\">\n<p class=\"c-article-author-affiliation__address\">Cardiac Arrhythmia Service, Johns Hopkins University School of Medicine, Baltimore, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Hugh Calkins<\/p>\n<\/li>\n<li id=\"Aff25\">\n<p class=\"c-article-author-affiliation__address\">Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jeffrey L. Anderson,\u00a0Stacey Knight\u00a0&amp;\u00a0Michael J. Cutler<\/p>\n<\/li>\n<li id=\"Aff26\">\n<p class=\"c-article-author-affiliation__address\">Division of Cardiology, University of Utah, Salt Lake City, UT, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jeffrey L. Anderson<\/p>\n<\/li>\n<li id=\"Aff27\">\n<p class=\"c-article-author-affiliation__address\">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jennifer A. Brody,\u00a0Joshua C. Bis,\u00a0Bruce M. Psaty\u00a0&amp;\u00a0Nona Sotoodehnia<\/p>\n<\/li>\n<li id=\"Aff28\">\n<p class=\"c-article-author-affiliation__address\">Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">John Barnard<\/p>\n<\/li>\n<li id=\"Aff29\">\n<p class=\"c-article-author-affiliation__address\">Department of Epidemiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">John E. Hokanson\u00a0&amp;\u00a0Kendra Young<\/p>\n<\/li>\n<li id=\"Aff30\">\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Physiology, Department of Clinical Sciences, Sk\u00e5ne University Hospital and Lund University, Lund, Sweden<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Linda S. B. Johnson<\/p>\n<\/li>\n<li id=\"Aff31\">\n<p class=\"c-article-author-affiliation__address\">Institute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lorenz Risch<\/p>\n<\/li>\n<li id=\"Aff32\">\n<p class=\"c-article-author-affiliation__address\">Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lorenz Risch<\/p>\n<\/li>\n<li id=\"Aff33\">\n<p class=\"c-article-author-affiliation__address\">Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lorne J. Gula\u00a0&amp;\u00a0Jason D. Roberts<\/p>\n<\/li>\n<li id=\"Aff34\">\n<p class=\"c-article-author-affiliation__address\">Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lydia Coulter Kwee<\/p>\n<\/li>\n<li id=\"Aff35\">\n<p class=\"c-article-author-affiliation__address\">Cardiology\/Electrophysiology, University Hospital Basel, University of Basel, Basel, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael K\u00fchne<\/p>\n<\/li>\n<li id=\"Aff36\">\n<p class=\"c-article-author-affiliation__address\">The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael Preuss,\u00a0Roelof A. J. Smit\u00a0&amp;\u00a0Ruth J. F. Loos<\/p>\n<\/li>\n<li id=\"Aff37\">\n<p class=\"c-article-author-affiliation__address\">Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Namrata Gupta,\u00a0Stacey Gabriel\u00a0&amp;\u00a0Daniel I. Chasman<\/p>\n<\/li>\n<li id=\"Aff38\">\n<p class=\"c-article-author-affiliation__address\">Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Navid A. Nafissi\u00a0&amp;\u00a0Svati H. Shah<\/p>\n<\/li>\n<li id=\"Aff39\">\n<p class=\"c-article-author-affiliation__address\">Department of Epidemiology, University of Washington, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nicholas L. Smith\u00a0&amp;\u00a0Bruce M. Psaty<\/p>\n<\/li>\n<li id=\"Aff40\">\n<p class=\"c-article-author-affiliation__address\">Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nicholas L. Smith\u00a0&amp;\u00a0Susan R. Heckbert<\/p>\n<\/li>\n<li id=\"Aff41\">\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Sciences, Clinical Research Center, Lund University, Malm\u00f6, Sweden<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Peter M. Nilsson<\/p>\n<\/li>\n<li id=\"Aff42\">\n<p class=\"c-article-author-affiliation__address\">Department of Internal Medicine, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Peter M. Nilsson<\/p>\n<\/li>\n<li id=\"Aff43\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Pim van der Harst<\/p>\n<\/li>\n<li id=\"Aff44\">\n<p class=\"c-article-author-affiliation__address\">Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Quinn S. Wells\u00a0&amp;\u00a0Dan M. Roden<\/p>\n<\/li>\n<li id=\"Aff45\">\n<p class=\"c-article-author-affiliation__address\">Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Renae L. Judy\u00a0&amp;\u00a0Scott M. Damrauer<\/p>\n<\/li>\n<li id=\"Aff46\">\n<p class=\"c-article-author-affiliation__address\">Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Renae L. Judy\u00a0&amp;\u00a0Scott M. Damrauer<\/p>\n<\/li>\n<li id=\"Aff47\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Renate B. Schnabel\u00a0&amp;\u00a0Paulus Kirchhof<\/p>\n<\/li>\n<li id=\"Aff48\">\n<p class=\"c-article-author-affiliation__address\">German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Hamburg\/Kiel\/L\u00fcbeck, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Renate B. Schnabel\u00a0&amp;\u00a0Paulus Kirchhof<\/p>\n<\/li>\n<li id=\"Aff49\">\n<p class=\"c-article-author-affiliation__address\">Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Renee Johnson\u00a0&amp;\u00a0Diane Fatkin<\/p>\n<\/li>\n<li id=\"Aff50\">\n<p class=\"c-article-author-affiliation__address\">School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Renee Johnson\u00a0&amp;\u00a0Diane Fatkin<\/p>\n<\/li>\n<li id=\"Aff51\">\n<p class=\"c-article-author-affiliation__address\">Department of Medicine, University of Utah, Salt Lake City, UT, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stacey Knight<\/p>\n<\/li>\n<li id=\"Aff52\">\n<p class=\"c-article-author-affiliation__address\">Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Tetsushi Furukawa<\/p>\n<\/li>\n<li id=\"Aff53\">\n<p class=\"c-article-author-affiliation__address\">Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Thomas W. Blackwell<\/p>\n<\/li>\n<li id=\"Aff54\">\n<p class=\"c-article-author-affiliation__address\">Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Yuan-I Min<\/p>\n<\/li>\n<li id=\"Aff55\">\n<p class=\"c-article-author-affiliation__address\">Department of Medicine and the School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Zachary W. M. Laksman<\/p>\n<\/li>\n<li id=\"Aff56\">\n<p class=\"c-article-author-affiliation__address\">Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alvaro Alonso<\/p>\n<\/li>\n<li id=\"Aff57\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christine M. Albert<\/p>\n<\/li>\n<li id=\"Aff58\">\n<p class=\"c-article-author-affiliation__address\">McKusick\u2013Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Dan E. Arking<\/p>\n<\/li>\n<li id=\"Aff59\">\n<p class=\"c-article-author-affiliation__address\">Divisions of Preventive Medicine and Genetics, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Daniel I. Chasman<\/p>\n<\/li>\n<li id=\"Aff60\">\n<p class=\"c-article-author-affiliation__address\">Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Daniel J. Rader\u00a0&amp;\u00a0Scott M. Damrauer<\/p>\n<\/li>\n<li id=\"Aff61\">\n<p class=\"c-article-author-affiliation__address\">Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David Conen<\/p>\n<\/li>\n<li id=\"Aff62\">\n<p class=\"c-article-author-affiliation__address\">University of Massachusetts Chan Medical School Worcester, Worcester, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David D. McManus<\/p>\n<\/li>\n<li id=\"Aff63\">\n<p class=\"c-article-author-affiliation__address\">Cardiology Department, St. Vincent\u2019s Hospital, Sydney, New South Wales, Australia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Diane Fatkin<\/p>\n<\/li>\n<li id=\"Aff64\">\n<p class=\"c-article-author-affiliation__address\">NHLBI and Boston University\u2019s Framingham Heart Study, Framingham, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Emelia J. Benjamin\u00a0&amp;\u00a0Kathryn L. Lunetta<\/p>\n<\/li>\n<li id=\"Aff65\">\n<p class=\"c-article-author-affiliation__address\">Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Emelia J. Benjamin<\/p>\n<\/li>\n<li id=\"Aff66\">\n<p class=\"c-article-author-affiliation__address\">Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Eric Boerwinkle<\/p>\n<\/li>\n<li id=\"Aff67\">\n<p class=\"c-article-author-affiliation__address\">Department of Medical Genetics, Oslo University Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ingrid E. Christophersen<\/p>\n<\/li>\n<li id=\"Aff68\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiology, Lund University Diabetes Center and Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Sk\u00e5ne University Hospital, Lund, Sweden<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">J. Gustav Smith<\/p>\n<\/li>\n<li id=\"Aff69\">\n<p class=\"c-article-author-affiliation__address\">The Wallenberg Laboratory\/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">J. Gustav Smith<\/p>\n<\/li>\n<li id=\"Aff70\">\n<p class=\"c-article-author-affiliation__address\">Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jason D. Roberts<\/p>\n<\/li>\n<li id=\"Aff71\">\n<p class=\"c-article-author-affiliation__address\">Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Laura M. Raffield<\/p>\n<\/li>\n<li id=\"Aff72\">\n<p class=\"c-article-author-affiliation__address\">Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael H. Cho<\/p>\n<\/li>\n<li id=\"Aff73\">\n<p class=\"c-article-author-affiliation__address\">Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Mina K. Chung<\/p>\n<\/li>\n<li id=\"Aff74\">\n<p class=\"c-article-author-affiliation__address\">Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Morten S. Olesen<\/p>\n<\/li>\n<li id=\"Aff75\">\n<p class=\"c-article-author-affiliation__address\">Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Morten S. Olesen<\/p>\n<\/li>\n<li id=\"Aff76\">\n<p class=\"c-article-author-affiliation__address\">Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Paulus Kirchhof<\/p>\n<\/li>\n<li id=\"Aff77\">\n<p class=\"c-article-author-affiliation__address\">Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ruth J. F. Loos<\/p>\n<\/li>\n<li id=\"Aff78\">\n<p class=\"c-article-author-affiliation__address\">Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Saman Nazarian<\/p>\n<\/li>\n<li id=\"Aff79\">\n<p class=\"c-article-author-affiliation__address\">Dell Medical School, Austin, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sanghamitra Mohanty<\/p>\n<\/li>\n<li id=\"Aff80\">\n<p class=\"c-article-author-affiliation__address\">Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Susan R. Heckbert<\/p>\n<\/li>\n<li id=\"Aff81\">\n<p class=\"c-article-author-affiliation__address\">Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women\u2019s Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Susan Redline<\/p>\n<\/li>\n<li id=\"Aff82\">\n<p class=\"c-article-author-affiliation__address\">Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University (TMDU) Graduate School of Medical and Dental Sciences, Tokyo, Japan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Toshihiro Tanaka<\/p>\n<\/li>\n<li id=\"Aff83\">\n<p class=\"c-article-author-affiliation__address\">BioResource Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Toshihiro Tanaka<\/p>\n<\/li>\n<li id=\"Aff84\">\n<p class=\"c-article-author-affiliation__address\">Life Science and Bioethics Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Yusuke Ebana<\/p>\n<\/li>\n<li id=\"Aff85\">\n<p class=\"c-article-author-affiliation__address\">Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Steven A. Lubitz\u00a0&amp;\u00a0Patrick T. Ellinor<\/p>\n<\/li>\n<li id=\"Aff86\">\n<p class=\"c-article-author-affiliation__address\">Regeneron Genetics Center, Tarrytown, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Goncalo Abecasis,\u00a0Xiaodong Bai,\u00a0Suganthi Balasubramanian,\u00a0Aris Baras,\u00a0Christina Beechert,\u00a0Boris Boutkov,\u00a0Michael Cantor,\u00a0Giovanni Coppola,\u00a0Tanima De,\u00a0Andrew Deubler,\u00a0Aris Economides,\u00a0Gisu Eom,\u00a0Manuel A. R. Ferreira,\u00a0Caitlin Forsythe,\u00a0Erin D. Fuller,\u00a0Zhenhua Gu,\u00a0Lukas Habegger,\u00a0Alicia Hawes,\u00a0Marcus B. Jones,\u00a0Katia Karalis,\u00a0Shareef Khalid,\u00a0Olga Krasheninina,\u00a0Rouel Lanche,\u00a0Michael Lattari,\u00a0Dadong Li,\u00a0Alexander Lopez,\u00a0Luca A. Lotta,\u00a0Kia Manoochehri,\u00a0Adam J. Mansfield,\u00a0Evan K. Maxwell,\u00a0Jason Mighty,\u00a0Lyndon J. Mitnaul,\u00a0Mona Nafde,\u00a0Jonas Nielsen,\u00a0Sean O\u2019Keeffe,\u00a0Max Orelus,\u00a0John D. Overton,\u00a0Maria Sotiropoulos Padilla,\u00a0Razvan Panea,\u00a0Tommy Polanco,\u00a0Manasi Pradhan,\u00a0Ayesha Rasool,\u00a0Jeffrey G. Reid,\u00a0William Salerno,\u00a0Thomas D. Schleicher,\u00a0Alan Shuldiner,\u00a0Katherine Siminovitch,\u00a0Jeffrey C. Staples,\u00a0Ricardo H. Ulloa,\u00a0Niek Verweij,\u00a0Louis Widom,\u00a0Sarah E. Wolf\u00a0&amp;\u00a0Gon\u00e7alo Abecasis<\/p>\n<\/li>\n<li id=\"Aff87\">\n<p class=\"c-article-author-affiliation__address\">University of Michigan, Ann Arbor, MI, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Goncalo Abecasis,\u00a0Gon\u00e7alo Abecasis,\u00a0Larry Bielak,\u00a0Jeffrey Curtis,\u00a0Matthew Flickinger,\u00a0Colin Gross,\u00a0Hyun Min Kang,\u00a0Sharon Kardia,\u00a0Jonathon LeFaive,\u00a0Patricia Peyser,\u00a0Jacob Pleiness,\u00a0Albert Vernon Smith,\u00a0Jennifer Smith,\u00a0Daniel Taliun,\u00a0Peter VandeHaar,\u00a0Jiongming Wang,\u00a0Joshua Weinstock,\u00a0Cristen Willer,\u00a0Ketian Yu,\u00a0Wei Zhao\u00a0&amp;\u00a0Sebastian Zoellner<\/p>\n<\/li>\n<li id=\"Aff88\">\n<p class=\"c-article-author-affiliation__address\">New York Genome Center, New York, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Namiko Abe,\u00a0Karen Bunting,\u00a0Bo-Juen Chen,\u00a0Heather Geiger,\u00a0Soren Germer,\u00a0Melissa Marton,\u00a0Catherine Reeves,\u00a0Nicolas Robine,\u00a0Alexi Runnels,\u00a0Tanja Smith,\u00a0Lara Winterkorn\u00a0&amp;\u00a0Michael Zody<\/p>\n<\/li>\n<li id=\"Aff89\">\n<p class=\"c-article-author-affiliation__address\">Broad Institute of MIT and Harvard, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Francois Aguet,\u00a0Kristin Ardlie,\u00a0Clary Clish,\u00a0Pradeep Natarajan\u00a0&amp;\u00a0Seyedeh Maryam Zekavat<\/p>\n<\/li>\n<li id=\"Aff90\">\n<p class=\"c-article-author-affiliation__address\">Children\u2019s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Laura Almasy<\/p>\n<\/li>\n<li id=\"Aff91\">\n<p class=\"c-article-author-affiliation__address\">University of Maryland, College Park, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Seth Ament,\u00a0Amber Beitelshees,\u00a0Christy Chang,\u00a0Coleen Damcott,\u00a0Scott Devine,\u00a0Mao Fu,\u00a0Da-Wei Gong,\u00a0Yue Guan,\u00a0Daniel Harris,\u00a0Elliott Hong,\u00a0Michael Kessler,\u00a0Joshua Lewis,\u00a0Patrick McArdle,\u00a0Braxton D. Mitchell,\u00a0May E. Montasser,\u00a0James Perry,\u00a0Toni Pollin,\u00a0Robert Reed,\u00a0Kathleen Ryan,\u00a0Shabnam Salimi,\u00a0Amol Shetty,\u00a0Elizabeth Streeten,\u00a0Simeon Taylor\u00a0&amp;\u00a0Huichun Xu<\/p>\n<\/li>\n<li id=\"Aff92\">\n<p class=\"c-article-author-affiliation__address\">University of Washington, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Peter Anderson,\u00a0Jai Broome,\u00a0Erin Buth,\u00a0Matthew Conomos,\u00a0Colleen Davis,\u00a0Leslie Emery,\u00a0Chris Frazar,\u00a0Stephanie M. Fullerton,\u00a0Stephanie Gogarten,\u00a0 Ben Heavner,\u00a0Craig Johnson,\u00a0Alyna Khan,\u00a0Cathy Laurie,\u00a0Cecelia Laurie,\u00a0David Levine,\u00a0Susanne May,\u00a0Daniel McGoldrick,\u00a0Caitlin McHugh,\u00a0Sarah C. Nelson,\u00a0Deborah Nickerson,\u00a0Ken Rice,\u00a0Josh Smith,\u00a0Adrienne M. Stilp,\u00a0Adam Szpiro,\u00a0Timothy A. Thornton,\u00a0Machiko Threlkeld,\u00a0David Tirschwell,\u00a0Catherine Tong,\u00a0Fei Fei Wang,\u00a0Bruce Weir,\u00a0Kayleen Williams\u00a0&amp;\u00a0Quenna Wong<\/p>\n<\/li>\n<li id=\"Aff93\">\n<p class=\"c-article-author-affiliation__address\">University of Mississippi, Oxford, MS, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Pramod Anugu,\u00a0Adolfo Correa,\u00a0Lynette Ekunwe,\u00a0Yan Gao,\u00a0Michael Hall,\u00a0Hao Mei\u00a0&amp;\u00a0Nancy Min<\/p>\n<\/li>\n<li id=\"Aff94\">\n<p class=\"c-article-author-affiliation__address\">National Institutes of Health, Bethesda, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Deborah Applebaum-Bowden<\/p>\n<\/li>\n<li id=\"Aff95\">\n<p class=\"c-article-author-affiliation__address\">University of Kentucky, Lexington, KY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Donna K. Arnett<\/p>\n<\/li>\n<li id=\"Aff96\">\n<p class=\"c-article-author-affiliation__address\">Duke University, Durham, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Allison Ashley-Koch,\u00a0Yongmei Liu\u00a0&amp;\u00a0Marilyn Telen<\/p>\n<\/li>\n<li id=\"Aff97\">\n<p class=\"c-article-author-affiliation__address\">University of Alabama, Tuscaloosa, AL, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stella Aslibekyan,\u00a0Bertha Hidalgo,\u00a0Marguerite Ryan Irvin,\u00a0Merry-Lynn McDonald\u00a0&amp;\u00a0Hemant Tiwari<\/p>\n<\/li>\n<li id=\"Aff98\">\n<p class=\"c-article-author-affiliation__address\">Stanford University, Palo Alto, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Tim Assimes,\u00a0Carlos Bustamante,\u00a0Chris Gignoux,\u00a0Yu Liu,\u00a0Emmanuel Mignot,\u00a0David T. Paik,\u00a0Marco Perez,\u00a0Michael Snyder,\u00a0Hua Tang\u00a0&amp;\u00a0Joseph Wu<\/p>\n<\/li>\n<li id=\"Aff99\">\n<p class=\"c-article-author-affiliation__address\">Medical College of Wisconsin, Milwaukee, WI, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Paul Auer\u00a0&amp;\u00a0Ulrich Broeckel<\/p>\n<\/li>\n<li id=\"Aff100\">\n<p class=\"c-article-author-affiliation__address\">Johns Hopkins University, Baltimore, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Dimitrios Avramopoulos,\u00a0Emily Barron-Casella,\u00a0Terri Beaty,\u00a0Diane Becker,\u00a0Lewis Becker,\u00a0James Casella,\u00a0Kimberly Jones,\u00a0Barry Make,\u00a0Rasika Mathias,\u00a0Rakhi Naik,\u00a0Wendy Post,\u00a0Ingo Ruczinski,\u00a0Steven Salzberg,\u00a0Margaret Taub,\u00a0Dhananjay Vaidya\u00a0&amp;\u00a0Lisa Yanek<\/p>\n<\/li>\n<li id=\"Aff101\">\n<p class=\"c-article-author-affiliation__address\">Providence Health Care, Vancouver, British Columbia, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Najib Ayas,\u00a0Jeff O\u2019Connell\u00a0&amp;\u00a0Tim O\u2019Connor<\/p>\n<\/li>\n<li id=\"Aff102\">\n<p class=\"c-article-author-affiliation__address\">Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Adithya Balasubramanian,\u00a0Huyen Dinh,\u00a0Harsha Doddapaneni,\u00a0Shannon Dugan-Perez,\u00a0Jesse Farek,\u00a0Richard Gibbs,\u00a0Yi Han,\u00a0Jianhong Hu,\u00a0Deepti Jain,\u00a0Ziad Khan,\u00a0Sandra Lee,\u00a0Vipin Menon,\u00a0Ginger Metcalf,\u00a0Zeineen Momin,\u00a0Donna Muzny,\u00a0Caitlin Nessner,\u00a0Osuji Nkechinyere,\u00a0Geoffrey Okwuonu,\u00a0Mahitha Rajendran,\u00a0Sejal Salvi,\u00a0Jireh Santibanez\u00a0&amp;\u00a0Jennifer Watt<\/p>\n<\/li>\n<li id=\"Aff103\">\n<p class=\"c-article-author-affiliation__address\">Tempus, University of Colorado Anschutz Medical Campus, Aurora, CO, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Kathleen Barnes<\/p>\n<\/li>\n<li id=\"Aff104\">\n<p class=\"c-article-author-affiliation__address\">Columbia University, New York, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">R. Graham Barr\u00a0&amp;\u00a0Danish Saleheen<\/p>\n<\/li>\n<li id=\"Aff105\">\n<p class=\"c-article-author-affiliation__address\">The Emmes Corporation, Rockville, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lucas Barwick<\/p>\n<\/li>\n<li id=\"Aff106\">\n<p class=\"c-article-author-affiliation__address\">Cleveland Clinic, Fairfax, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Gerald Beck,\u00a0Suzy Comhair\u00a0&amp;\u00a0Serpil Erzurum<\/p>\n<\/li>\n<li id=\"Aff107\">\n<p class=\"c-article-author-affiliation__address\">National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Rebecca Beer,\u00a0Weiniu Gan,\u00a0Cashell Jaquish,\u00a0Andrew Johnson,\u00a0 Dan Levy,\u00a0James Luo,\u00a0Julie Mikulla,\u00a0George Papanicolaou\u00a0&amp;\u00a0Pankaj Qasba<\/p>\n<\/li>\n<li id=\"Aff108\">\n<p class=\"c-article-author-affiliation__address\">University of Pittsburgh, Pittsburgh, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Takis Benos,\u00a0Mark Geraci,\u00a0Mark Gladwin,\u00a0Ryan L. Minster,\u00a0Frank Sciurba,\u00a0Daniel E. Weeks\u00a0&amp;\u00a0Yingze Zhang<\/p>\n<\/li>\n<li id=\"Aff109\">\n<p class=\"c-article-author-affiliation__address\">Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco \u2013 Hemope, Recife, Pernambuco, Brazil<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Marcos Bezerra<\/p>\n<\/li>\n<li id=\"Aff110\">\n<p class=\"c-article-author-affiliation__address\">School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">John Blangero,\u00a0Joanne Curran,\u00a0Ravi Duggirala,\u00a0Harald Goring,\u00a0Michael Mahaney\u00a0&amp;\u00a0Juan Manuel Peralta<\/p>\n<\/li>\n<li id=\"Aff111\">\n<p class=\"c-article-author-affiliation__address\">Wake Forest Baptist Health, Winston-Salem, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Donald W. Bowden,\u00a0David Herrington,\u00a0Nicholette Palmer\u00a0&amp;\u00a0Beverly Snively<\/p>\n<\/li>\n<li id=\"Aff112\">\n<p class=\"c-article-author-affiliation__address\">National Jewish Health, Denver, CO, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Russell Bowler,\u00a0James Crapo,\u00a0Tasha Fingerlin,\u00a0Elizabeth Regan\u00a0&amp;\u00a0Snow Xueyan Zhao<\/p>\n<\/li>\n<li id=\"Aff113\">\n<p class=\"c-article-author-affiliation__address\">University of Texas Health at Houston, Houston, TX, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Deborah Brown,\u00a0Paul de Vries,\u00a0Myriam Fornage\u00a0&amp;\u00a0James Hixson<\/p>\n<\/li>\n<li id=\"Aff114\">\n<p class=\"c-article-author-affiliation__address\">University of California San Francisco, San Francisco, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Esteban Burchard,\u00a0Ryan Hernandez\u00a0&amp;\u00a0Shannon Kelly<\/p>\n<\/li>\n<li id=\"Aff115\">\n<p class=\"c-article-author-affiliation__address\">Brigham and Women\u2019s Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Brian Cade,\u00a0Vincent Carey,\u00a0Juan P. Casas Romero,\u00a0Peter Castaldi,\u00a0Dawn DeMeo,\u00a0Auyon Ghosh,\u00a0Craig Hersh,\u00a0Brian Hobbs,\u00a0Meryl LeBoff,\u00a0Jiwon Lee,\u00a0JoAnn Manson,\u00a0Matt Moll,\u00a0Dandi Qiao,\u00a0Edwin Silverman,\u00a0Tamar Sofer,\u00a0Jessica Lasky Su,\u00a0Jody Sylvia,\u00a0Scott T. Weiss\u00a0&amp;\u00a0Carla Wilson<\/p>\n<\/li>\n<li id=\"Aff116\">\n<p class=\"c-article-author-affiliation__address\">University of Colorado at Denver, Denver, CO, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jonathan Cardwell,\u00a0Sameer Chavan,\u00a0Michelle Daya,\u00a0Shanshan Gao,\u00a0Daniel Grine,\u00a0Greg Kinney,\u00a0Ethan Lange,\u00a0Leslie Lange,\u00a0Susan Mathai,\u00a0Bonnie Neltner,\u00a0Julia Powers Becker,\u00a0Meher Preethi Boorgula,\u00a0Nicholas Rafaels,\u00a0Pamela Russell,\u00a0David Schwartz,\u00a0Aniket Shetty,\u00a0Garrett Storm,\u00a0Tarik Walker,\u00a0Avram Walts\u00a0&amp;\u00a0Ivana Yang<\/p>\n<\/li>\n<li id=\"Aff117\">\n<p class=\"c-article-author-affiliation__address\">University of Montreal, Montreal, Quebec, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Julie Carrier<\/p>\n<\/li>\n<li id=\"Aff118\">\n<p class=\"c-article-author-affiliation__address\">Washington State University, Pullman, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Cara Carty<\/p>\n<\/li>\n<li id=\"Aff119\">\n<p class=\"c-article-author-affiliation__address\">University of California, Los Angeles, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Richard Casaburi,\u00a0Carolyn Crandall\u00a0&amp;\u00a0Karol Watson<\/p>\n<\/li>\n<li id=\"Aff120\">\n<p class=\"c-article-author-affiliation__address\">National Taiwan University, Taipei, Taiwan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Yi-Cheng Chang\u00a0&amp;\u00a0Lee-Ming Chuang<\/p>\n<\/li>\n<li id=\"Aff121\">\n<p class=\"c-article-author-affiliation__address\">University of Virginia, Charlottesville, VA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Wei-Min Chen,\u00a0Charles Farber,\u00a0Ani Manichaikul,\u00a0Josyf C. Mychaleckyj,\u00a0Aakrosh Ratan\u00a0&amp;\u00a0Stephen Rich<\/p>\n<\/li>\n<li id=\"Aff122\">\n<p class=\"c-article-author-affiliation__address\">Lundquist Institute, Torrance, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Yii-Der Ida Chen,\u00a0Xiuqing Guo,\u00a0Xiaohui Li,\u00a0Henry Lin,\u00a0Jerome Rotter,\u00a0Kevin Sandow\u00a0&amp;\u00a0Kent D. Taylor<\/p>\n<\/li>\n<li id=\"Aff123\">\n<p class=\"c-article-author-affiliation__address\">National Health Research Institute Taiwan, Zhunan, Taiwan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ren-Hua Chung\u00a0&amp;\u00a0Chao Agnes Hsiung<\/p>\n<\/li>\n<li id=\"Aff124\">\n<p class=\"c-article-author-affiliation__address\">University of Vermont, Burlington, VT, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Elaine Cornell,\u00a0Jon Peter Durda\u00a0&amp;\u00a0Russell Tracy<\/p>\n<\/li>\n<li id=\"Aff125\">\n<p class=\"c-article-author-affiliation__address\">Boston University, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">L. Adrienne Cupples,\u00a0Honghuang Lin,\u00a0Gina Peloso\u00a0&amp;\u00a0Vasan S. Ramachandran<\/p>\n<\/li>\n<li id=\"Aff126\">\n<p class=\"c-article-author-affiliation__address\">Vitalant Research Institute, San Francisco, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Brian Custer<\/p>\n<\/li>\n<li id=\"Aff127\">\n<p class=\"c-article-author-affiliation__address\">University of Chicago, Chicago, IL, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sean David<\/p>\n<\/li>\n<li id=\"Aff128\">\n<p class=\"c-article-author-affiliation__address\">Mayo Clinic, Rochester, MN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Mariza de Andrade<\/p>\n<\/li>\n<li id=\"Aff129\">\n<p class=\"c-article-author-affiliation__address\">Washington University in St. Louis, St. Louis, MO, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lisa de las Fuentes,\u00a0Susan K. Dutcher,\u00a0Lucinda Fulton,\u00a0C. Charles Gu,\u00a0D. C. Rao,\u00a0Karen Schwander\u00a0&amp;\u00a0Yun Ju Sung<\/p>\n<\/li>\n<li id=\"Aff130\">\n<p class=\"c-article-author-affiliation__address\">Vanderbilt University, Nashville, TN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael DeBaun<\/p>\n<\/li>\n<li id=\"Aff131\">\n<p class=\"c-article-author-affiliation__address\">University of Cincinnati, Cincinnati, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ranjan Deka<\/p>\n<\/li>\n<li id=\"Aff132\">\n<p class=\"c-article-author-affiliation__address\">University of North Carolina, Chapel Hill, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Qing Duan,\u00a0Nora Franceschini,\u00a0Yun Li\u00a0&amp;\u00a0Kari North<\/p>\n<\/li>\n<li id=\"Aff133\">\n<p class=\"c-article-author-affiliation__address\">Brown University, Providence, RI, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Charles Eaton,\u00a0Simin Liu\u00a0&amp;\u00a0Stephen McGarvey<\/p>\n<\/li>\n<li id=\"Aff134\">\n<p class=\"c-article-author-affiliation__address\">Harvard University, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Adel El Boueiz,\u00a0Wonji Kim,\u00a0Sean McFarland\u00a0&amp;\u00a0Vijay G. Sankaran<\/p>\n<\/li>\n<li id=\"Aff135\">\n<p class=\"c-article-author-affiliation__address\">Fred Hutchinson Cancer Research Center, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Margery Gass,\u00a0Jeff Haessler,\u00a0Charles Kooperberg,\u00a0Ulrike Peters\u00a0&amp;\u00a0Lesley Tinker<\/p>\n<\/li>\n<li id=\"Aff136\">\n<p class=\"c-article-author-affiliation__address\">Icahn School of Medicine at Mount Sinai, New York, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bruce Gelb,\u00a0Eimear Kenny\u00a0&amp;\u00a0Girish Nadkarni<\/p>\n<\/li>\n<li id=\"Aff137\">\n<p class=\"c-article-author-affiliation__address\">Beth Israel Deaconess Medical Center, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Robert Gerszten\u00a0&amp;\u00a0James Wilson<\/p>\n<\/li>\n<li id=\"Aff138\">\n<p class=\"c-article-author-affiliation__address\">Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David Glahn<\/p>\n<\/li>\n<li id=\"Aff139\">\n<p class=\"c-article-author-affiliation__address\">University of Colorado Anschutz Medical Campus, Aurora, CO, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sharon Graw,\u00a0Luisa Mestroni\u00a0&amp;\u00a0Matthew Taylor<\/p>\n<\/li>\n<li id=\"Aff140\">\n<p class=\"c-article-author-affiliation__address\">Mass General Brigham, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Kathryn J. Gray<\/p>\n<\/li>\n<li id=\"Aff141\">\n<p class=\"c-article-author-affiliation__address\">McGill University, Montr\u00e9al, Quebec, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David M. Haas\u00a0&amp;\u00a0John Kimoff<\/p>\n<\/li>\n<li id=\"Aff142\">\n<p class=\"c-article-author-affiliation__address\">University of Calgary, Calgary, Alberta, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Patrick Hanly<\/p>\n<\/li>\n<li id=\"Aff143\">\n<p class=\"c-article-author-affiliation__address\">Yale University, New Haven, CT, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nicola L. Hawley<\/p>\n<\/li>\n<li id=\"Aff144\">\n<p class=\"c-article-author-affiliation__address\">Tulane University, New Orleans, LA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jiang He<\/p>\n<\/li>\n<li id=\"Aff145\">\n<p class=\"c-article-author-affiliation__address\">University of Iowa, Iowa City, IA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Karin Hoth\u00a0&amp;\u00a0Robert Wallace<\/p>\n<\/li>\n<li id=\"Aff146\">\n<p class=\"c-article-author-affiliation__address\">Tri-Service General Hospital National Defense Medical Center, Taipei, Taiwan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Yi-Jen Hung<\/p>\n<\/li>\n<li id=\"Aff147\">\n<p class=\"c-article-author-affiliation__address\">Blood Works Northwest, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Haley Huston,\u00a0Jill Johnsen,\u00a0Barbara Konkle\u00a0&amp;\u00a0Sarah Ruuska<\/p>\n<\/li>\n<li id=\"Aff148\">\n<p class=\"c-article-author-affiliation__address\">Taichung Veterans General Hospital Taiwan, Taichung, Taiwan<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Chii Min Hwu,\u00a0Wen-Jane Lee\u00a0&amp;\u00a0Wayne Hui-Heng Sheu<\/p>\n<\/li>\n<li id=\"Aff149\">\n<p class=\"c-article-author-affiliation__address\">Oklahoma State University Medical Center, Tulsa, OK, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Rebecca Jackson<\/p>\n<\/li>\n<li id=\"Aff150\">\n<p class=\"c-article-author-affiliation__address\">Emory University, Atlanta, GA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Rich Johnston,\u00a0Lawrence S. Phillips,\u00a0Zhaohui Qin,\u00a0Vivien Sheehan\u00a0&amp;\u00a0Stephanie L. Sherman<\/p>\n<\/li>\n<li id=\"Aff151\">\n<p class=\"c-article-author-affiliation__address\">Albert Einstein College of Medicine, New York, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Robert Kaplan\u00a0&amp;\u00a0Sylvia Smoller<\/p>\n<\/li>\n<li id=\"Aff152\">\n<p class=\"c-article-author-affiliation__address\">Loyola University, Chicago, IL, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Holly Kramer<\/p>\n<\/li>\n<li id=\"Aff153\">\n<p class=\"c-article-author-affiliation__address\">Harvard School of Public Health, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christoph Lange\u00a0&amp;\u00a0Xihong Lin<\/p>\n<\/li>\n<li id=\"Aff154\">\n<p class=\"c-article-author-affiliation__address\">Ohio State University, Columbus, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ulysses Magalang<\/p>\n<\/li>\n<li id=\"Aff155\">\n<p class=\"c-article-author-affiliation__address\">Broad Institute of MIT and Harvard, Massachusetts General Hospital, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alisa Manning<\/p>\n<\/li>\n<li id=\"Aff156\">\n<p class=\"c-article-author-affiliation__address\">George Washington University, Washington, DC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lisa Martin<\/p>\n<\/li>\n<li id=\"Aff157\">\n<p class=\"c-article-author-affiliation__address\">RTI International, Research Triangle Park, NC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Becky McNeil\u00a0&amp;\u00a0Cora Parker<\/p>\n<\/li>\n<li id=\"Aff158\">\n<p class=\"c-article-author-affiliation__address\">Massachusetts General Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">James Meigs<\/p>\n<\/li>\n<li id=\"Aff159\">\n<p class=\"c-article-author-affiliation__address\">University of Arizona, Tucson, AZ, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Deborah A. Meyers<\/p>\n<\/li>\n<li id=\"Aff160\">\n<p class=\"c-article-author-affiliation__address\">National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Mollie Minear<\/p>\n<\/li>\n<li id=\"Aff161\">\n<p class=\"c-article-author-affiliation__address\">Oklahoma Medical Research Foundation, Oklahoma City, OK, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Courtney Montgomery<\/p>\n<\/li>\n<li id=\"Aff162\">\n<p class=\"c-article-author-affiliation__address\">Ministry of Health, Government of Samoa, Apia, Samoa<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Take Naseri<\/p>\n<\/li>\n<li id=\"Aff163\">\n<p class=\"c-article-author-affiliation__address\">Howard University, Washington, DC, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sergei Nekhai<\/p>\n<\/li>\n<li id=\"Aff164\">\n<p class=\"c-article-author-affiliation__address\">University at Buffalo, Buffalo, NY, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Heather Ochs-Balcom<\/p>\n<\/li>\n<li id=\"Aff165\">\n<p class=\"c-article-author-affiliation__address\">University of Pennsylvania, Philadelphia, PA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Allan Pack\u00a0&amp;\u00a0Sarah Tishkoff<\/p>\n<\/li>\n<li id=\"Aff166\">\n<p class=\"c-article-author-affiliation__address\">University of Minnesota, Minneapolis, MN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">James Pankow,\u00a0Michael Tsai\u00a0&amp;\u00a0Scott Vrieze<\/p>\n<\/li>\n<li id=\"Aff167\">\n<p class=\"c-article-author-affiliation__address\">Northwestern University, Evanston, IL, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Laura Rasmussen-Torvik<\/p>\n<\/li>\n<li id=\"Aff168\">\n<p class=\"c-article-author-affiliation__address\">Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alex Reiner<\/p>\n<\/li>\n<li id=\"Aff169\">\n<p class=\"c-article-author-affiliation__address\">Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Muagututi\u2019a Sefuiva Reupena<\/p>\n<\/li>\n<li id=\"Aff170\">\n<p class=\"c-article-author-affiliation__address\">University of Ottawa, Ottawa, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Rebecca Robillard<\/p>\n<\/li>\n<li id=\"Aff171\">\n<p class=\"c-article-author-affiliation__address\">Universidade de Sao Paulo, Sao Paulo, Brazil<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ester Cerdeira Sabino<\/p>\n<\/li>\n<li id=\"Aff172\">\n<p class=\"c-article-author-affiliation__address\">Harvard Medical School, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christine Seidman\u00a0&amp;\u00a0Jonathan Seidman<\/p>\n<\/li>\n<li id=\"Aff173\">\n<p class=\"c-article-author-affiliation__address\">Universit\u00e9 Laval, Quebec City, Quebec, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Fr\u00e9d\u00e9ric S\u00e9ri\u00e8s<\/p>\n<\/li>\n<li id=\"Aff174\">\n<p class=\"c-article-author-affiliation__address\">UMass Memorial Medical Center, Worcester, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Brian Silver<\/p>\n<\/li>\n<li id=\"Aff175\">\n<p class=\"c-article-author-affiliation__address\">University of Saskatchewan, Saskatoon, Saskatchewan, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Robert Skomro<\/p>\n<\/li>\n<li id=\"Aff176\">\n<p class=\"c-article-author-affiliation__address\">University of Southern California, Los Angeles, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">David Van Den Berg<\/p>\n<\/li>\n<li id=\"Aff177\">\n<p class=\"c-article-author-affiliation__address\">Brigham and Women\u2019s Hospital, Mass General Brigham, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Heming Wang<\/p>\n<\/li>\n<li id=\"Aff178\">\n<p class=\"c-article-author-affiliation__address\">Indiana University, Bloomington, IN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jennifer Wessel<\/p>\n<\/li>\n<li id=\"Aff179\">\n<p class=\"c-article-author-affiliation__address\">Henry Ford Health System, Detroit, MI, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">L. Keoki Williams<\/p>\n<\/li>\n<li id=\"Aff180\">\n<p class=\"c-article-author-affiliation__address\">Case Western Reserve University, Cleveland, OH, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Xiaofeng Zhu<\/p>\n<\/li>\n<p>S.H.C, S.J.J., S.A.L. and P.T.E. conceived and designed the study. S.H.C., S.J.J., V.N.M., N.A.M., L.-C.W., J.P.P., G.J., C.R. and J.L.H. performed data curation and data processing for the discovery datasets. S.H.C. and S.J.J. performed the main statistical and bioinformatic analyses in the discovery datasets. A.S.v.F., A.N., A.T., B.G., D.R.V.W., D.D., D.H., E.Z.S., G.E.D., H.C., J.L.A., J.A.B., J.B., J.E.H., J.D.S., J.C.B., K.Y., L.S.B.J., L.R., L.J.G., L.C.K., M.K., M.P., N.A.N., N.L.S., P.M.N., P.v.d.H., Q.S.W., R.L.J., R.S., R.J., R.A.J.S., S. Knight, T.F., T.W.B., Y.-I.M., Z.T.Y., Z.W.M.L., C.R.B., A.A., B.M.P., C.M.A., D.E.A., D.M.R., D.I.C., D.J.R., D.C., D.D.M., D.F., E.J.B., E.B., G.M.M., I.E.C., J.G.S., J.D.R., L.M.R., M.B.S., M.H.C., M.J.C., M.R., M.K.C., M.S.O., M.F.S., N.S., P.K., R.J.F.L., S.N., S.M., S.M.D., S. Kaab, S.R.H., S.R., S.H.S., T.T., Y.E., C.T.R., M.S.S., K.L.L., S.A.L. and P.T.E. were involved in site-specific sample ascertainment, phenotype data collection, DNA collection for sequencing, data processing or supervision for the TOPMed-CCDG, CCDG and FOURIER datasets. N.G. and S.G. were involved in the coordination of sequencing at the Broad Institute for various discovery datasets. V.N.M., N.A.M., L.-C.W., J.P.P., C.R., M.D.C., V.N. and X.W. contributed critically to the analysis plan. C.M.H. performed data curation and bioinformatic analyses for the Geisinger MyCode dataset, with contributions from Regeneron Genetics Center authors, as specified in <a data-track=\"click\" data-track-label=\"link\" data-track-action=\"section anchor\" href=\"http:\/\/www.nature.com\/articles\/s41588-025-02074-9#Sec35\" target=\"_blank\" rel=\"noopener\">Supplementary Note<\/a>. G.S., D.O.A. and D.F.G. were responsible for data curation and bioinformatic analyses in the deCODE dataset. H.H. and K.S. were responsible for coordination and supervision of the deCODE dataset. L.X., M.C.H. and H.M. were responsible for the functional studies of KDM5B, including CRISPR knockout, optical mapping and RNA-seq analyses. K.L.L., S.A.L. and P.T.E. supervised the overall study. S.H.C., S.J.J. and P.T.E. wrote the manuscript. All authors critically revised and approved the manuscript.<\/p>\n","protected":false},"excerpt":{"rendered":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA Seung Hoan Choi,\u00a0Sean J. Jurgens,\u00a0Ling Xiao,\u00a0Matthew&hellip;\n","protected":false},"author":2,"featured_media":18502,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[3971,3973,12303,3967,3970,12304,12305,3972,3968,12306,267,3900,3969,70,16,15],"class_list":{"0":"post-18501","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-agriculture","9":"tag-animal-genetics-and-genomics","10":"tag-atrial-fibrillation","11":"tag-biomedicine","12":"tag-cancer-research","13":"tag-cardiomyopathies","14":"tag-dna-sequencing","15":"tag-gene-function","16":"tag-general","17":"tag-genetic-association-study","18":"tag-genetics","19":"tag-genomics","20":"tag-human-genetics","21":"tag-science","22":"tag-uk","23":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114334834563943425","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/18501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=18501"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/18501\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/18502"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=18501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=18501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=18501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}