{"id":254169,"date":"2025-07-10T18:39:13","date_gmt":"2025-07-10T18:39:13","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/254169\/"},"modified":"2025-07-10T18:39:13","modified_gmt":"2025-07-10T18:39:13","slug":"scientists-unlock-the-dementia-code-groundbreaking-research-uncovers-four-early-warning-patterns-that-may-help-prevent-disease-before-it-strikes","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/254169\/","title":{"rendered":"Scientists unlock the dementia code &#8211; groundbreaking research uncovers four &#8216;early warning patterns&#8217; that may help prevent disease before it strikes"},"content":{"rendered":"<p class=\"mol-para-with-font\">Researchers have identified four distinct pathways to developing dementia\u2014and it could revolutionise how doctors diagnose and treat the devastating disease.\u00a0<\/p>\n<p class=\"mol-para-with-font\">American researchers <a style=\"font-weight: bold;\" class=\"\" rel=\"nofollow noreferrer noopener\" target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(25)00275-0\/fulltext\">analysed data <\/a>from more than 24,000 patients and found four\u00a0distinct pathways that lead to someone developing the degenerative brain condition.<\/p>\n<p class=\"mol-para-with-font\">The pathways are psychiatric conditions, brain dysfunction illnesses, mild cognitive impairments and heart disease.<\/p>\n<p class=\"mol-para-with-font\">The scientists found that each pathway had its own characteristics and could be applied to a specific demographic, which might help doctors identify the disease in their patients faster.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Previous studies have concluded that early intervention in dementia cases can increase patients&#8217; treatment options and therefore improve their quality of life.\u00a0 \u00a0<\/p>\n<p class=\"mol-para-with-font\">In the new study, published in medical journal <a style=\"font-weight: bold;\" class=\"\" rel=\"nofollow noreferrer noopener\" target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(25)00275-0\/fulltext\">The Lancet<\/a>, scientists found that in more that\u00a0 than a quarter of cases, health issues paved a predictable pathway to dementia.<\/p>\n<p class=\"mol-para-with-font\">For example, patients who had problems with high blood pressure followed by a depressive episode were more likely to develop Alzheimer&#8217;s disease.\u00a0<\/p>\n<p class=\"mol-para-with-font\">This is a key discovery, and supports doctors giving patients personalised treatment plans.<\/p>\n<p>   <img decoding=\"async\" id=\"i-263971d4b76c5ab2\" src=\"https:\/\/www.europesays.com\/uk\/wp-content\/uploads\/2025\/07\/100185195-14893131-image-a-37_1752150273168.jpg\" height=\"357\" width=\"634\" alt=\"A breakthrough study has revealed there are four roads to the debilitating illness dementia\" class=\"blkBorder img-share\" style=\"max-width:100%\" loading=\"lazy\" \/>   <\/p>\n<p class=\"imageCaption\">A breakthrough study has revealed there are four roads to the debilitating illness dementia<\/p>\n<p class=\"mol-para-with-font\">Early intervention for non-brain disease related illnesses\u2014for instance, offering GLP-1 medication to reduce weight which would bring down cholesterol levels and blood pressure\u2014could in theory help prevent a patient from developing dementia.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;Recognising these sequential patterns rather than focusing on diagnoses in isolation may help clinicians improve Alzheimer&#8217;s disease diagnosis,&#8217; said lead author Dr. Timothy Chang, assistant professor in Neurology at UCLA Health.\u00a0<\/p>\n<p class=\"mol-para-with-font\">More than 944,000 people in the UK are thought to be living with dementia, while the figure is thought to be around seven million in the US.<\/p>\n<p class=\"mol-para-with-font\">In the UK dementia cases are expected to sky-rocket to 1.4million people by 2040 according to University College London scientists.<\/p>\n<p class=\"mol-para-with-font\">Alzheimer&#8217;s disease is the leading cause of dementia\u2014a condition that blights the lives of millions of people, robbing loved ones of their memories.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Alzheimer&#8217;s Research UK analysis found 74,261 people died from dementia in 2022 compared with 69,178 a year earlier, making it the country&#8217;s biggest killer.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Recent analysis by the Alzheimer&#8217;s Society estimated the overall annual cost of the dementia to the UK is \u00a342billion a year.<\/p>\n<p class=\"mol-para-with-font\">Other research has proposed lifestyle changes to reduce your risk of dementia like\u00a0preventing hearing loss, socialising and quitting smoking.<\/p>\n<p>  The four pathways to dementia\u00a0\u00a0  <\/p>\n<ul class=\"mol-bullets-with-font\">\n<li class=\"\">Mental health pathway: Psychiatric conditions leading to cognitive decline<\/li>\n<li class=\"\">Encephalopathy pathway: Brain dysfunction conditions that escalate over time<\/li>\n<li class=\"\">Mild cognitive impairment pathway: Gradual cognitive decline progression<\/li>\n<li class=\"\">Vascular disease pathway: Cardiovascular conditions that contribute to dementia risk<\/li>\n<\/ul>\n<p class=\"mol-para-with-font\">Classic early signs of the debilitating illness are memory loss, difficulty concentrating, communication issues and mood problems.<\/p>\n<p class=\"mol-para-with-font\">But there are other lesser known signs, with earlier\u00a0<a style=\"font-weight: bold;\" target=\"_self\" class=\"\" href=\"https:\/\/www.dailymail.co.uk\/health\/article-14798359\/signs-dementia-memory-sensory-changes.html\" rel=\"noopener\">studies<\/a>\u00a0connecting changes in sight, hearing, touch and balance with the early stages of the disease.<\/p>\n<p class=\"mol-para-with-font\">Experts called for these sensory changes to be included in diagnostic tests to help people be diagnosed sooner.\u00a0<\/p>\n<p class=\"mol-para-with-font\">It comes just days after <a style=\"font-weight: bold;\" target=\"_self\" class=\"\" href=\"https:\/\/www.dailymail.co.uk\/health\/article-14888853\/Experts-five-minute-activity-reduce-chances-developing-dementia.html\" rel=\"noopener\">scientists <\/a>revealed simple activities can keep your organs like your brain &#8216;youthful&#8217; reducing your risk of Alzheimer&#8217;s disease.<\/p>\n<p class=\"mol-para-with-font\">The team found a &#8216;youthful&#8217; brain &#8216;provided protection&#8217; from cognitive decline.<\/p>\n<p class=\"mol-para-with-font\">They suggested that a routine of vigorous exercise, a diet rich in poultry and oily fish, and keeping your intellect sharp with further education can all help.<\/p>\n<p class=\"mol-para-with-font\">Meanwhile, smoking, alcohol, eating processed meat, and living in a deprived area accelerated organ aging.<\/p>\n<p class=\"mol-para-with-font\">However, you don&#8217;t need to sign up to further education to keep your brain young\u2014a simple crossword in the morning can do the trick.<\/p>\n<p class=\"mol-para-with-font\">Other <a style=\"font-weight: bold;\" class=\"\" rel=\"noreferrer noopener\" target=\"_blank\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3885259\/\">research <\/a>has found the five-minute activity slows down memory decline in the early stages of dementia.<\/p>\n<p>   <img decoding=\"async\" id=\"i-ca2aad0eee739477\" src=\"https:\/\/www.europesays.com\/uk\/wp-content\/uploads\/2025\/07\/77039039-14893131-Around_900_000_Brits_are_currently_thought_to_have_the_memory_ro-a-35_175214977765.jpeg\" height=\"594\" width=\"634\" alt=\"The number of patients with dementia in the UK is forecast to rise by 42 per cent by 2040\" class=\"blkBorder img-share\" style=\"max-width:100%\" loading=\"lazy\" \/>   <\/p>\n<p class=\"imageCaption\">The number of patients with dementia in the UK is forecast to rise by 42 per cent by 2040<\/p>\n<p>Your browser does not support iframes.<\/p>\n<p class=\"mol-para-with-font\">Previously, researchers found moderate-to-vigorous exercise lowers risk of dementia by 41 per cent.<\/p>\n<p class=\"mol-para-with-font\">This is exercise which gets the heart racing and breathing to the point you can still speak but not sing, like brisk walking, jogging or cycling.<\/p>\n<p class=\"mol-para-with-font\">However, some scientists suggest high intensity workouts (HITT) could be better than cardio for staving off dementia, because they force more blood to the brain.<\/p>\n<p class=\"mol-para-with-font\">HITT sees people do short bursts of intense exercise with 80 per cent of their effort, followed by a recovery period to allow their heart rate to drop again.<\/p>\n<p class=\"mol-para-with-font\">Often, they involve quick exercises like burpees, mountain climbers, jump squats, kettlebell swings and treadmill sprints.<\/p>\n<p class=\"mol-para-with-font\">However, it is best to avoid high-intensity workouts before bedtime, as a study found it reduces sleep, which can increase your risk of dementia.<\/p>\n<p class=\"mol-para-with-font\">Other researchers have suggested the ideal age to ramp up exercise to prevent dementia is between the ages of 45 and 65.<\/p>\n<p class=\"mol-para-with-font\">But experts have warned that pushing yourself too far during exercise can trigger life-threatening brain-bleeds.<\/p>\n<p class=\"mol-para-with-font\">Last month, a super-fit personal trainer <a style=\"font-weight: bold;\" target=\"_self\" class=\"\" href=\"https:\/\/www.dailymail.co.uk\/health\/article-14853057\/Warning-gym-mistake-life-threatening-brain-bleed.html\" rel=\"noopener\">claimed <\/a>medics blamed her sudden brain bleed on &#8216;years of overdoing it at the gym&#8217;.<\/p>\n<p class=\"mol-para-with-font\">Linzi Todd, from Northampton, suffered a massive brain bleed in March triggered by fluid leaking from her spine, that doctors put down to her history of intense exercise.<\/p>\n<p class=\"mol-para-with-font\">Previous studies have suggested excessive exercise may trigger brain bleeds, leading to potentially fatal strokes or brain haemorrhages.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Researchers have identified four distinct pathways to developing dementia\u2014and it could revolutionise how doctors diagnose and treat 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