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<\/p>\nResearchers at Tel Aviv University have developed a new mouse model that accurately mimics a rare and severe genetic disorder caused by mutations in the GRIN2D gene \u2013 allowing for study of the disease\u2019s progression and the testing of potential drug therapies. <\/p>\n
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Researchers at Tel Aviv University\u2019s Gray Faculty of Medical and Health Sciences<\/a> have successfully developed a mouse model that accurately replicates an extremely rare and sometimes fatal genetic disorder caused by mutations in the GRIN2D gene. This disorder, characterised by developmental epilepsy<\/a>, severe motor delays and often premature death, affects fewer than 40 people worldwide.<\/p>\n \u00a0\u201cWe were contacted by the parents of an Israeli child named Adam, now eight years old, who is one of only about 40 people worldwide diagnosed with this extremely rare genetic disease,\u201d Professor Karen Avraham, Dean of the Faculty and co-leader of the study. \u201cIt involves a mutation in a gene called GRIN2D, which causes developmental epilepsy, significant motor and cognitive delays, and in some cases, premature death.\u201d<\/p>\n Creating a window into the disease\u00a0<\/p>\n The team, led by Professor Moran Rubinstein and Professor Avraham, faced early challenges in modelling the disease. The first mouse models carrying the mutation died within weeks, mirroring the severity seen in human patients but limiting opportunities for research.<\/p>\n To overcome this, the scientists used advanced genetic engineering to create a new strain that could carry the mutation without immediate symptoms. This allowed them to breed affected offspring suitable for study. These affected mice exhibited symptoms paralleling human patients \u2013 early neurological impairments, epilepsy and a drastically shortened lifespan.<\/p>\n Because the disease is so rare, its progression over time is not well understood<\/p>\n \u201cBecause the disease is so rare, its progression over time is not well understood. The mouse model helped us characterise its symptoms at different ages, and the tests we performed revealed interesting findings: neurological symptoms such as epilepsy, hyperactivity, and severe motor impairments were evident in the mice from infancy,\u201d Prof Rubinstein said. \u201cCognitive impairment, by contrast, appeared later and gradually worsened. Additionally, the affected mice had a short lifespan -most did not survive to sexual maturity, dying from severe seizures.\u201d<\/p>\n Understanding brain function and progression<\/p>\n Further experiments focused on the communication between neurons \u2013 particularly in the cerebellum \u2013 which is critical for motor control. Abnormal neuronal activity was detected as early as two weeks old in the mice \u2013 indicating early disease onset. While some neuronal activity normalised with age, defective communication and structural neuronal changes developed over time.<\/p>\n Electroencephalography (EEG) tests revealed a distinctive pattern of ongoing disrupted brain activity, unique from other epilepsy forms where brain function normalises between seizures.<\/p>\n Professor Rubinstein emphasises the significance: Testing treatments and future directions<\/p>\n With the validated model, the team began testing existing drugs. Notably, ketamine, previously considered a treatment option, worsened seizures in the mice. Conversely, memantine and phenytoin showed partial improvements in brain function and seizure control.<\/p>\n Modelling the disease with a mouse model is a crucial tool for guiding clinical decisions in treating patients with rare diseases<\/p>\n \u201cModelling the disease with a mouse model is a crucial tool for guiding clinical decisions in treating patients with rare diseases. The model enables us to test the efficacy of existing drugs, as well as the safety and efficacy of new drugs before trying them on patients,\u201d said Professor Moran Hausman-Kedem from Dana-Dwek Children\u2019s Hospital.<\/p>\n \u00a0\u201cFor example, findings from the mouse model helped demonstrate that memantine may help prevent seizures. Using a mouse model provides critical information about new treatment approaches for rare diseases, where the number of patients is too small to allow broad statistical validation. In such cases, animal model experiments can offer breakthrough insights, advancing the ability to deliver personalised medicine.\u201d<\/p>\n Hope for patients and families<\/p>\n Professor Rubinstein concludes on an optimistic note about ongoing research: Related topics
\u201cIn most forms of epilepsy, seizures result from disrupted brain activity, but between seizures, brain activity is relatively normal,\u201d Professor Rubinstein said. \u201cIn this disease, however \u2013 both in children and in the mice \u2013 brain activity is continuously disrupted. Moreover, using specific metrics we developed, we identified the same abnormalities in both mice and humans \u2013 an especially strong indication of the model\u2019s validity.\u201d<\/p>\n
\u201cIn this study, we created a mouse model of a rare genetic disease caused by a mutation in the GRIN2D gene. Using this model, we gained a better understanding of disease progression and tested the efficacy of several existing drugs. Currently, in follow-up studies, we are testing additional treatments \u2013 both pharmacological and genetic \u2013 and have obtained promising results, such as improved cognition and motor function and extended lifespan in the affected mice. We very much hope that our work will bring hope and progress to families and children facing this severe and rare disorder, as well as to those affected by other brain diseases caused by similar mechanisms.\u201d<\/p>\n
Animal Models<\/a>, Central Nervous System (CNS)<\/a>, Disease Research<\/a>, Drug Discovery<\/a>, Drug Repurposing<\/a>, Gene Testing<\/a>, Genetic Analysis<\/a>, In Vivo<\/a>, Neurosciences<\/a>, Personalised Medicine<\/a>, Translational Science<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Researchers at Tel Aviv University have developed a new mouse model that accurately mimics a rare and severe…\n","protected":false},"author":2,"featured_media":255652,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[267,70,16,15],"class_list":{"0":"post-255651","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-uk","11":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114833539197112043","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/255651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=255651"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/255651\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/255652"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=255651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=255651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=255651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}