{"id":273499,"date":"2025-07-19T01:36:11","date_gmt":"2025-07-19T01:36:11","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/273499\/"},"modified":"2025-07-19T01:36:11","modified_gmt":"2025-07-19T01:36:11","slug":"research-identifies-genetic-predictor-of-weight-loss-with-glp-1ras","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/273499\/","title":{"rendered":"Research identifies genetic predictor of weight loss with GLP-1RAs"},"content":{"rendered":"<p>A new study published by Cleveland Clinic researchers investigating the genetic underpinnings of weight loss response has identified a gene, neurobeachin (NBEA), as a predictor of how individuals respond to GLP-1RAs, the class of medications behind popular treatments like liraglutide and semaglutide.<\/p>\n<p>\u00a0<\/p>\n<p>While GLP-1RAs have shown promise in helping individuals lose weight, their effectiveness varies widely. This study, which analyzed large-scale real-world data from the NIH All of Us cohort and the UK Biobank, discovered that individuals with certain genetic variations of NBEA \u2014a gene encoding a protein kinase A anchor protein\u2014 are significantly more likely to experience substantial weight loss\u2014or, conversely, non-responsiveness\u2014when prescribed GLP-1RAs.<\/p>\n<p>\u00a0<\/p>\n<p>Key findings include:<\/p>\n<ul>\n<li>Individuals with a &#8220;responsive&#8221; NBEA genetic score were up to 82% more likely to achieve significant weight loss with liraglutide and semaglutide.<\/li>\n<li>Those with a &#8220;non-responsive&#8221; NBEA score were up to 50% more likely to not lose weight on liraglutide.<\/li>\n<li>Validation across two independent cohorts strengthens the reliability of these results.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p>This research paves the way for personalized obesity treatment strategies, allowing healthcare providers to use genetic insights to identify patients most likely to benefit from GLP-1RA medications.<\/p>\n<p>\u00a0<\/p>\n<p>Link to paper: <a href=\"https:\/\/url.us.m.mimecastprotect.com\/s\/thhdCJ6AvktAOkP8lUGhmiyAsrv?domain=urldefense.com\" target=\"_blank\" rel=\"noopener\">https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16612<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"A new study published by Cleveland Clinic researchers investigating the genetic underpinnings of weight loss response has identified&hellip;\n","protected":false},"author":2,"featured_media":264598,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[33728,267,103531,14822,70,16,15],"class_list":{"0":"post-273499","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-cleveland-clinic","9":"tag-genetics","10":"tag-glp-1obesity-drugsweight-loss-medicationspersonalized-medicineglp-1rasemaglutide","11":"tag-newswise","12":"tag-science","13":"tag-uk","14":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114877339322223924","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/273499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=273499"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/273499\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/264598"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=273499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=273499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=273499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}