Key findings from the study include:<\/strong><\/p>\n\u2022 KRAS mutations in advanced non-small cell lung cancer were linked to poorer response to a common treatment (EGFR inhibitors), suggesting alternative treatments may be needed.
\u2022 NF1 mutations improved responses to immunotherapy and worsened responses to certain targeted therapies, highlighting their complex role in treatment.
\u2022 PI3K pathway mutations, which regulate cell growth, had varying effects depending on cancer type, with different responses in breast, melanoma and renal cancers.
\u2022 DNA repair pathway mutations improved immunotherapy effectiveness in lung cancer by increasing tumor instability.
\u2022 Mutations in immune-related pathways were associated with better survival rates for lung cancer patients treated with immunotherapy, suggesting not all mutations hinder treatment success.<\/p>\n
While cancer treatments have traditionally followed a one-size-fits-all approach, where patients with the same type of cancer receive the same standard therapies, the study underscores the importance of precision medicine, which tailors treatment based on a patient\u2019s unique genetic makeup.<\/p>\n
Yet while vast amounts of mutation data exist, only a small number have clinically validated treatments, limiting potential real-world impact and patient benefit. To bridge this gap, based on their findings, Liu\u2019s team used machine learning to analyze how multiple mutations interact to influence treatment outcomes.<\/p>\n
![\"Ruishan](\"https:\/\/www.europesays.com\/uk\/wp-content\/uploads\/2025\/08\/Untitled-design-40-300x300.png\")
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\u201cOur goal was to find patterns that might not be obvious at first glance.\u201d Ruishan Liu<\/p>\n
They developed a Random Survival Forest (RSF) model, a predictive tool designed to refine treatment recommendations for lung cancer patients. By integrating large-scale real-world data with machine learning, the model identified new mutation-treatment interactions.<\/p>\n
\u201cOur goal was to find patterns that might not be obvious at first glance, and then translate these insights into real-world tools that can expand access to immunotherapy for people with cancer,\u201d Lui said.\u00a0 \u201cOne key innovation lies in integrating huge amounts of data with advanced statistical and machine learning techniques to uncover previously unrecognized mutation-treatment interactions.\u201d<\/p>\n
While further clinical trials are needed, Liu sees this study as an important step toward making cancer treatment more precise and personalized.<\/p>\n
\u201cThis research shows the power of computational science in transforming complex clinical and genomic data into actionable insights,\u201d she said. \u201cIt\u2019s deeply fulfilling to contribute to tools and knowledge that can directly improve patient care.\u201d<\/p>\n
Published on February 11th, 2025<\/p>\n
Last updated on February 11th, 2025<\/p>\n","protected":false},"excerpt":{"rendered":"Using advanced computational methods, the researchers discovered 95 genes significantly associated with survival in cancers such as breast,…\n","protected":false},"author":2,"featured_media":316888,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[267,70,16,15],"class_list":{"0":"post-316887","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-uk","11":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114969993325737649","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/316887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=316887"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/316887\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/316888"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=316887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=316887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=316887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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