{"id":321435,"date":"2025-08-06T03:00:56","date_gmt":"2025-08-06T03:00:56","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/321435\/"},"modified":"2025-08-06T03:00:56","modified_gmt":"2025-08-06T03:00:56","slug":"researchers-reveal-a-surprising-link-between-human-evolution-and-cancer","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/321435\/","title":{"rendered":"Researchers reveal a surprising link between human evolution and cancer"},"content":{"rendered":"

A new study is shedding light on an important connection between human evolution<\/a> and cancer. It reveals that some of the very genes that helped make our brains smarter are also being misused by cancer to help tumors grow. These findings could open the door to new ways of treating cancer\u2014by targeting genes that are unique to humans.<\/p>\n

Young Genes With Powerful Effects<\/p>\n

Led by Dr. LI Chuanyun at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences<\/a>, the research team focused on a rare class of genes called de novo genes. <\/p>\n

Unlike most genes that arise by copying and tweaking older ones, these genes appear from scratch, developing from DNA<\/a> that once had no role at all. Over time, these new genes gave rise to entirely new functions.<\/p>\n

Oncogenic roles of young human de novo genes. (CREDIT: IGDB) <\/p>\n

By comparing 120 mammalian genomes and analyzing data from 1,900 human tissue samples and 100 million protein spectra, the scientists identified 37 de novo genes that are found only in humans and our closest ape relatives. <\/p>\n

These genes tend to be active during early development, especially in the brain and reproductive organs like the testes. Their role in shaping human traits\u2014such as our large brain and advanced thinking\u2014has been suggested in earlier studies by the same team.<\/p>\n

But as this study shows, cancer seems to have found a dangerous use for them.<\/p>\n

Cancer Finds a Loophole in Human Evolution<\/p>\n

The researchers looked at over 5,200 tumor samples from 22 types of cancer<\/a>. They found that nearly half of these uniquely human genes became active in tumors. In normal adult tissues, they stay switched off. But in cancerous cells, something goes wrong\u2014and the genes switch back on.<\/p>\n

Related Stories<\/p>\n

One reason for this abnormal activity is a genetic structure called extrachromosomal circular DNA (ecDNA). These circular DNA fragments are separate from the chromosomes and often carry cancer-related genes. They can increase gene expression rapidly and unpredictably. Many of the human-specific genes were found on these ecDNA structures inside tumor cells.<\/p>\n

Using tools like CRISPR-Cas9<\/a> and small interfering RNA (siRNA), the team tested how these genes affect cancer cell growth. About 57% of the genes were shown to actively boost tumor cell growth. Even worse, high levels of these gene products in a tumor often meant a poorer outcome for patients.<\/p>\n

Dr. LI explained the dual nature of these genes by saying, \u201cThis is evolution\u2019s gamble. The same genetic innovations that make us smart appear to make us vulnerable, but we are turning this evolutionary vulnerability<\/a> into clinical opportunity.\u201d<\/p>\n

Upregulation and temporospatial expansion of de novo gene expression in tumors. (CREDIT: LI Chuanyun, et al.) Turning the Tables on Tumors<\/p>\n

Two genes in particular stood out: ELFN1-AS1 and TYMSOS. These genes don\u2019t exist in any other species and stay inactive in healthy adult tissues. However, they light up inside tumors, making them standout targets for cancer treatment. \u201cThese genes are like dormant bombs,\u201d said Dr. LI. \u201cThey\u2019re completely absent in other species, inactive in healthy adult tissues, but get reactivated only in tumors\u2014making them ideal targets.\u201d<\/p>\n

That\u2019s exactly what the researchers tested. Working with Dr. CHENG Qiang from Peking University<\/a>, they created mRNA vaccines to train the immune system to recognize proteins that these genes produce. When the team tested the vaccines in humanized mouse models\u2014mice with human-like immune systems\u2014the treatment triggered a strong immune response against the tumors.<\/p>\n

Combining the mRNA vaccines with existing immunotherapy made the results even stronger. In addition, immune cells from real cancer patients responded to the vaccine<\/a> by targeting the gene-specific proteins. This shows that the approach may work in human patients, not just in lab animals.<\/p>\n

Association between genome reorganization and altered expression profiles of de novo genes in tumors. (CREDIT: LI Chuanyun, et al.) From Hidden Code to New Hope<\/p>\n

Co-senior author Dr. AN Ni explained that researchers had long overlooked these genes. \u201cThese evolutionarily young genes were invisible to cancer research for two key reasons,\u201d she said. \u201cFirst, they\u2019re absent in standard model organisms, and second, genomic databases misannotated them as non-coding or pseudogenes.\u201d<\/p>\n

Since common lab animals like mice or rats lack these genes, most cancer studies<\/a> ignored them. And because databases mislabeled them, scientists didn\u2019t explore their role in disease. Now, better tools and more complete genomic data are helping researchers uncover their significance.<\/p>\n

This study stands out because it connects two different fields\u2014evolutionary biology and cancer medicine. On one side, the genes helped humans become more intelligent. On the other, tumors now use those same genes to grow. By understanding both sides, scientists can develop new ways to fight cancer\u2014possibly using the same evolutionary tools that built the human brain<\/a>.<\/p>\n

Newly originated de novo genes in humans and their evolutionary trajectories. (CREDIT: LI Chuanyun, et al.) Hope Through History<\/p>\n

Using our evolutionary past to fight one of today\u2019s deadliest diseases feels both scientific and poetic. The genes that helped shape human intelligence<\/a> could now help save lives. <\/p>\n

Because of this research, doctors may gain new tools to fight cancer in ways they couldn\u2019t before\u2014by targeting genes unique to our species. The future of cancer therapy may rest in understanding what makes us human.<\/p>\n

Research findings are available online in the journal Cell Genomics<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"A new study is shedding light on an important connection between human evolution and cancer. It reveals that…\n","protected":false},"author":2,"featured_media":321436,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[267,70,16,15],"class_list":{"0":"post-321435","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-uk","11":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114979594703267124","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/321435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=321435"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/321435\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/321436"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=321435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=321435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=321435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}