{"id":34800,"date":"2025-04-20T05:34:23","date_gmt":"2025-04-20T05:34:23","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/34800\/"},"modified":"2025-04-20T05:34:23","modified_gmt":"2025-04-20T05:34:23","slug":"potential-downsides-of-calorie-restriction","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/34800\/","title":{"rendered":"Potential downsides of calorie restriction"},"content":{"rendered":"<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"1.\">\n<p class=\"c-article-references__text\" id=\"ref-CR1\">Osborne, T. B., Mendel, L. B. &amp; Ferry, E. L. The effect of retardation of growth upon the breeding period and duration of life of rats. Science <b>45<\/b>, 294\u2013295 (1917).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.45.1160.294\" data-track-item_id=\"10.1126\/science.45.1160.294\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.45.1160.294\" aria-label=\"Article reference 1\" data-doi=\"10.1126\/science.45.1160.294\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BC3cvkvVyitA%3D%3D\" aria-label=\"CAS reference 1\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17760202\" aria-label=\"PubMed reference 1\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effect%20of%20retardation%20of%20growth%20upon%20the%20breeding%20period%20and%20duration%20of%20life%20of%20rats&amp;journal=Science&amp;doi=10.1126%2Fscience.45.1160.294&amp;volume=45&amp;pages=294-295&amp;publication_year=1917&amp;author=Osborne%2CTB&amp;author=Mendel%2CLB&amp;author=Ferry%2CEL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"2.\">\n<p class=\"c-article-references__text\" id=\"ref-CR2\">McCay, C. M., Crowell, M. F. &amp; Maynard, L. A. The effect of retarded growth upon the length of life span and upon the ultimate body size: one figure. J. Nutr. <b>10<\/b>, 63\u201379 (1935).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jn\/10.1.63\" data-track-item_id=\"10.1093\/jn\/10.1.63\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjn%2F10.1.63\" aria-label=\"Article reference 2\" data-doi=\"10.1093\/jn\/10.1.63\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaA2MXmtFCgug%3D%3D\" aria-label=\"CAS reference 2\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effect%20of%20retarded%20growth%20upon%20the%20length%20of%20life%20span%20and%20upon%20the%20ultimate%20body%20size%3A%20one%20figure&amp;journal=J.%20Nutr.&amp;doi=10.1093%2Fjn%2F10.1.63&amp;volume=10&amp;pages=63-79&amp;publication_year=1935&amp;author=McCay%2CCM&amp;author=Crowell%2CMF&amp;author=Maynard%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"3.\">\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Speakman, J. R., Mitchell, S. E. &amp; Mazidi, M. Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone. Exp. Gerontol. <b>86<\/b>, 28\u201338 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.exger.2016.03.011\" data-track-item_id=\"10.1016\/j.exger.2016.03.011\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.exger.2016.03.011\" aria-label=\"Article reference 3\" data-doi=\"10.1016\/j.exger.2016.03.011\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XlsF2htrw%3D\" aria-label=\"CAS reference 3\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27006163\" aria-label=\"PubMed reference 3\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calories%20or%20protein%3F%20The%20effect%20of%20dietary%20restriction%20on%20lifespan%20in%20rodents%20is%20explained%20by%20calories%20alone&amp;journal=Exp.%20Gerontol.&amp;doi=10.1016%2Fj.exger.2016.03.011&amp;volume=86&amp;pages=28-38&amp;publication_year=2016&amp;author=Speakman%2CJR&amp;author=Mitchell%2CSE&amp;author=Mazidi%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"4.\">\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Shanley, D. P. &amp; Kirkwood, T. B. Calorie restriction and aging: a life-history analysis. Evolution <b>54<\/b>, 740\u2013750 (2000).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BD3cvhvFyjtQ%3D%3D\" aria-label=\"CAS reference 4\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10937249\" aria-label=\"PubMed reference 4\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20and%20aging%3A%20a%20life-history%20analysis&amp;journal=Evolution&amp;volume=54&amp;pages=740-750&amp;publication_year=2000&amp;author=Shanley%2CDP&amp;author=Kirkwood%2CTB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"5.\">\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Weindruch, R., Walford, R. L., Fligiel, S. &amp; Guthrie, D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. <b>116<\/b>, 641\u2013654 (1986).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jn\/116.4.641\" data-track-item_id=\"10.1093\/jn\/116.4.641\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjn%2F116.4.641\" aria-label=\"Article reference 5\" data-doi=\"10.1093\/jn\/116.4.641\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaL287ntVygsQ%3D%3D\" aria-label=\"CAS reference 5\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=3958810\" aria-label=\"PubMed reference 5\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20retardation%20of%20aging%20in%20mice%20by%20dietary%20restriction%3A%20longevity%2C%20cancer%2C%20immunity%20and%20lifetime%20energy%20intake&amp;journal=J.%20Nutr.&amp;doi=10.1093%2Fjn%2F116.4.641&amp;volume=116&amp;pages=641-654&amp;publication_year=1986&amp;author=Weindruch%2CR&amp;author=Walford%2CRL&amp;author=Fligiel%2CS&amp;author=Guthrie%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"6.\">\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Perkins, S. N., Hursting, S. D., Phang, J. M. &amp; Haines, D. C. Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice. J. Invest. Dermatol. <b>111<\/b>, 292\u2013296 (1998).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1046\/j.1523-1747.1998.00270.x\" data-track-item_id=\"10.1046\/j.1523-1747.1998.00270.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1046%2Fj.1523-1747.1998.00270.x\" aria-label=\"Article reference 6\" data-doi=\"10.1046\/j.1523-1747.1998.00270.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1cXltFGgtL8%3D\" aria-label=\"CAS reference 6\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9699732\" aria-label=\"PubMed reference 6\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20reduces%20ulcerative%20dermatitis%20and%20infection-related%20mortality%20in%20p53-deficient%20and%20wild-type%20mice&amp;journal=J.%20Invest.%20Dermatol.&amp;doi=10.1046%2Fj.1523-1747.1998.00270.x&amp;volume=111&amp;pages=292-296&amp;publication_year=1998&amp;author=Perkins%2CSN&amp;author=Hursting%2CSD&amp;author=Phang%2CJM&amp;author=Haines%2CDC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"7.\">\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Colman, R. J. et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science <b>325<\/b>, 201\u2013204 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.1173635\" data-track-item_id=\"10.1126\/science.1173635\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.1173635\" aria-label=\"Article reference 7\" data-doi=\"10.1126\/science.1173635\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXos1SrtL0%3D\" aria-label=\"CAS reference 7\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19590001\" aria-label=\"PubMed reference 7\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2812811\" aria-label=\"PubMed Central reference 7\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20delays%20disease%20onset%20and%20mortality%20in%20rhesus%20monkeys&amp;journal=Science&amp;doi=10.1126%2Fscience.1173635&amp;volume=325&amp;pages=201-204&amp;publication_year=2009&amp;author=Colman%2CRJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"8.\">\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Colman, R. J. et al. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat. Commun. <b>5<\/b>, 3557 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/ncomms4557\" data-track-item_id=\"10.1038\/ncomms4557\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fncomms4557\" aria-label=\"Article reference 8\" data-doi=\"10.1038\/ncomms4557\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24691430\" aria-label=\"PubMed reference 8\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20reduces%20age-related%20and%20all-cause%20mortality%20in%20rhesus%20monkeys&amp;journal=Nat.%20Commun.&amp;doi=10.1038%2Fncomms4557&amp;volume=5&amp;publication_year=2014&amp;author=Colman%2CRJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"9.\">\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Pinney, D. O., Stephens, D. F. &amp; Pope, L. S. Lifetime effects of winter supplemental feed level and age at first parturition on range beef cows. J. Anim. Sci. <b>34<\/b>, 1067\u20131074 (1972).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.2527\/jas1972.3461067x\" data-track-item_id=\"10.2527\/jas1972.3461067x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.2527%2Fjas1972.3461067x\" aria-label=\"Article reference 9\" data-doi=\"10.2527\/jas1972.3461067x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaE387oslCrtg%3D%3D\" aria-label=\"CAS reference 9\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=5027302\" aria-label=\"PubMed reference 9\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Lifetime%20effects%20of%20winter%20supplemental%20feed%20level%20and%20age%20at%20first%20parturition%20on%20range%20beef%20cows&amp;journal=J.%20Anim.%20Sci.&amp;doi=10.2527%2Fjas1972.3461067x&amp;volume=34&amp;pages=1067-1074&amp;publication_year=1972&amp;author=Pinney%2CDO&amp;author=Stephens%2CDF&amp;author=Pope%2CLS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"10.\">\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Lawler, D. F. et al. Diet restriction and ageing in the dog: major observations over two decades. Br. J. Nutr. <b>99<\/b>, 793\u2013805 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1017\/S0007114507871686\" data-track-item_id=\"10.1017\/S0007114507871686\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1017%2FS0007114507871686\" aria-label=\"Article reference 10\" data-doi=\"10.1017\/S0007114507871686\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXkvFegsLk%3D\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18062831\" aria-label=\"PubMed reference 10\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diet%20restriction%20and%20ageing%20in%20the%20dog%3A%20major%20observations%20over%20two%20decades&amp;journal=Br.%20J.%20Nutr.&amp;doi=10.1017%2FS0007114507871686&amp;volume=99&amp;pages=793-805&amp;publication_year=2008&amp;author=Lawler%2CDF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"11.\">\n<p class=\"c-article-references__text\" id=\"ref-CR11\">McCay, C., Maynard, L., Sperling, G. &amp; Barnes, L. L. Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets restricted in calories. Nutr. Rev. <b>33<\/b>, 241\u2013243 (1975).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1753-4887.1975.tb05227.x\" data-track-item_id=\"10.1111\/j.1753-4887.1975.tb05227.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1753-4887.1975.tb05227.x\" aria-label=\"Article reference 11\" data-doi=\"10.1111\/j.1753-4887.1975.tb05227.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaE2M7psFSrtg%3D%3D\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1095975\" aria-label=\"PubMed reference 11\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Retarded%20growth%2C%20life%20span%2C%20ultimate%20body%20size%20and%20age%20changes%20in%20the%20albino%20rat%20after%20feeding%20diets%20restricted%20in%20calories&amp;journal=Nutr.%20Rev.&amp;doi=10.1111%2Fj.1753-4887.1975.tb05227.x&amp;volume=33&amp;pages=241-243&amp;publication_year=1975&amp;author=McCay%2CC&amp;author=Maynard%2CL&amp;author=Sperling%2CG&amp;author=Barnes%2CLL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"12.\">\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Bagherniya, M., Butler, A. E., Barreto, G. E. &amp; Sahebkar, A. The effect of fasting or calorie restriction on autophagy induction: a review of the literature. Ageing Res. Rev. <b>47<\/b>, 183\u2013197 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.arr.2018.08.004\" data-track-item_id=\"10.1016\/j.arr.2018.08.004\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.arr.2018.08.004\" aria-label=\"Article reference 12\" data-doi=\"10.1016\/j.arr.2018.08.004\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30172870\" aria-label=\"PubMed reference 12\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effect%20of%20fasting%20or%20calorie%20restriction%20on%20autophagy%20induction%3A%20a%20review%20of%20the%20literature&amp;journal=Ageing%20Res.%20Rev.&amp;doi=10.1016%2Fj.arr.2018.08.004&amp;volume=47&amp;pages=183-197&amp;publication_year=2018&amp;author=Bagherniya%2CM&amp;author=Butler%2CAE&amp;author=Barreto%2CGE&amp;author=Sahebkar%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"13.\">\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Fontana, L., Nehme, J. &amp; Demaria, M. Caloric restriction and cellular senescence. Mech. Ageing Dev. <b>176<\/b>, 19\u201323 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mad.2018.10.005\" data-track-item_id=\"10.1016\/j.mad.2018.10.005\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mad.2018.10.005\" aria-label=\"Article reference 13\" data-doi=\"10.1016\/j.mad.2018.10.005\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXitFKjt7%2FI\" aria-label=\"CAS reference 13\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30395873\" aria-label=\"PubMed reference 13\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20and%20cellular%20senescence&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2Fj.mad.2018.10.005&amp;volume=176&amp;pages=19-23&amp;publication_year=2018&amp;author=Fontana%2CL&amp;author=Nehme%2CJ&amp;author=Demaria%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"14.\">\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Radler, M. E., Wright, B. J., Walker, F. R., Hale, M. W. &amp; Kent, S. Calorie restriction increases lipopolysaccharide-induced neuropeptide Y immunolabeling and reduces microglial cell area in the arcuate hypothalamic nucleus. Neuroscience <b>285<\/b>, 236\u2013247 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.neuroscience.2014.11.014\" data-track-item_id=\"10.1016\/j.neuroscience.2014.11.014\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.neuroscience.2014.11.014\" aria-label=\"Article reference 14\" data-doi=\"10.1016\/j.neuroscience.2014.11.014\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXitFOnsr%2FJ\" aria-label=\"CAS reference 14\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25446356\" aria-label=\"PubMed reference 14\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20increases%20lipopolysaccharide-induced%20neuropeptide%20Y%20immunolabeling%20and%20reduces%20microglial%20cell%20area%20in%20the%20arcuate%20hypothalamic%20nucleus&amp;journal=Neuroscience&amp;doi=10.1016%2Fj.neuroscience.2014.11.014&amp;volume=285&amp;pages=236-247&amp;publication_year=2015&amp;author=Radler%2CME&amp;author=Wright%2CBJ&amp;author=Walker%2CFR&amp;author=Hale%2CMW&amp;author=Kent%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"15.\">\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Park, C. Y., Park, S., Kim, M. S., Kim, H. K. &amp; Han, S. N. Effects of mild calorie restriction on lipid metabolism and inflammation in liver and adipose tissue. Biochem. Biophys. Res. Commun. <b>490<\/b>, 636\u2013642 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.bbrc.2017.06.090\" data-track-item_id=\"10.1016\/j.bbrc.2017.06.090\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.bbrc.2017.06.090\" aria-label=\"Article reference 15\" data-doi=\"10.1016\/j.bbrc.2017.06.090\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtVOjsbvK\" aria-label=\"CAS reference 15\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28630003\" aria-label=\"PubMed reference 15\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20mild%20calorie%20restriction%20on%20lipid%20metabolism%20and%20inflammation%20in%20liver%20and%20adipose%20tissue&amp;journal=Biochem.%20Biophys.%20Res.%20Commun.&amp;doi=10.1016%2Fj.bbrc.2017.06.090&amp;volume=490&amp;pages=636-642&amp;publication_year=2017&amp;author=Park%2CCY&amp;author=Park%2CS&amp;author=Kim%2CMS&amp;author=Kim%2CHK&amp;author=Han%2CSN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"16.\">\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Green, C. L., Lamming, D. W. &amp; Fontana, L. Molecular mechanisms of dietary restriction promoting health and longevity. Nat. Rev. Mol. Cell Biol. <b>23<\/b>, 56\u201373 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41580-021-00411-4\" data-track-item_id=\"10.1038\/s41580-021-00411-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41580-021-00411-4\" aria-label=\"Article reference 16\" data-doi=\"10.1038\/s41580-021-00411-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitVajtrrF\" aria-label=\"CAS reference 16\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34518687\" aria-label=\"PubMed reference 16\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Molecular%20mechanisms%20of%20dietary%20restriction%20promoting%20health%20and%20longevity&amp;journal=Nat.%20Rev.%20Mol.%20Cell%20Biol.&amp;doi=10.1038%2Fs41580-021-00411-4&amp;volume=23&amp;pages=56-73&amp;publication_year=2022&amp;author=Green%2CCL&amp;author=Lamming%2CDW&amp;author=Fontana%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"17.\">\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Most, J., Tosti, V., Redman, L. M. &amp; Fontana, L. Calorie restriction in humans: an update. Ageing Res. Rev. <b>39<\/b>, 36\u201345 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.arr.2016.08.005\" data-track-item_id=\"10.1016\/j.arr.2016.08.005\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.arr.2016.08.005\" aria-label=\"Article reference 17\" data-doi=\"10.1016\/j.arr.2016.08.005\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27544442\" aria-label=\"PubMed reference 17\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20in%20humans%3A%20an%20update&amp;journal=Ageing%20Res.%20Rev.&amp;doi=10.1016%2Fj.arr.2016.08.005&amp;volume=39&amp;pages=36-45&amp;publication_year=2017&amp;author=Most%2CJ&amp;author=Tosti%2CV&amp;author=Redman%2CLM&amp;author=Fontana%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"18.\">\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Cooper, T. M., Mockett, R. J., Sohal, B. H., Sohal, R. S. &amp; Orr, W. C. Effect of caloric restriction on life span of the housefly, Musca domestica. FASEB J. <b>18<\/b>, 1591\u20131593 (2004).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1096\/fj.03-1464fje\" data-track-item_id=\"10.1096\/fj.03-1464fje\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1096%2Ffj.03-1464fje\" aria-label=\"Article reference 18\" data-doi=\"10.1096\/fj.03-1464fje\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXotFGitbY%3D\" aria-label=\"CAS reference 18\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15319362\" aria-label=\"PubMed reference 18\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20caloric%20restriction%20on%20life%20span%20of%20the%20housefly%2C%20Musca%20domestica&amp;journal=FASEB%20J.&amp;doi=10.1096%2Ffj.03-1464fje&amp;volume=18&amp;pages=1591-1593&amp;publication_year=2004&amp;author=Cooper%2CTM&amp;author=Mockett%2CRJ&amp;author=Sohal%2CBH&amp;author=Sohal%2CRS&amp;author=Orr%2CWC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"19.\">\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Mockett, R. J., Cooper, T. M., Orr, W. C. &amp; Sohal, R. S. Effects of caloric restriction are species-specific. Biogerontology <b>7<\/b>, 157\u2013160 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s10522-006-9004-3\" data-track-item_id=\"10.1007\/s10522-006-9004-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s10522-006-9004-3\" aria-label=\"Article reference 19\" data-doi=\"10.1007\/s10522-006-9004-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16628489\" aria-label=\"PubMed reference 19\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2835574\" aria-label=\"PubMed Central reference 19\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20caloric%20restriction%20are%20species-specific&amp;journal=Biogerontology&amp;doi=10.1007%2Fs10522-006-9004-3&amp;volume=7&amp;pages=157-160&amp;publication_year=2006&amp;author=Mockett%2CRJ&amp;author=Cooper%2CTM&amp;author=Orr%2CWC&amp;author=Sohal%2CRS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"20.\">\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Liao, C. Y., Rikke, B. A., Johnson, T. E., Diaz, V. &amp; Nelson, J. F. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell <b>9<\/b>, 92\u201395 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1474-9726.2009.00533.x\" data-track-item_id=\"10.1111\/j.1474-9726.2009.00533.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1474-9726.2009.00533.x\" aria-label=\"Article reference 20\" data-doi=\"10.1111\/j.1474-9726.2009.00533.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXhtlKnt74%3D\" aria-label=\"CAS reference 20\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19878144\" aria-label=\"PubMed reference 20\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genetic%20variation%20in%20the%20murine%20lifespan%20response%20to%20dietary%20restriction%3A%20from%20life%20extension%20to%20life%20shortening&amp;journal=Aging%20Cell&amp;doi=10.1111%2Fj.1474-9726.2009.00533.x&amp;volume=9&amp;pages=92-95&amp;publication_year=2010&amp;author=Liao%2CCY&amp;author=Rikke%2CBA&amp;author=Johnson%2CTE&amp;author=Diaz%2CV&amp;author=Nelson%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"21.\">\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Burnett, C. et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature <b>477<\/b>, 482\u2013485 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nature10296\" data-track-item_id=\"10.1038\/nature10296\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnature10296\" aria-label=\"Article reference 21\" data-doi=\"10.1038\/nature10296\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1WltLfK\" aria-label=\"CAS reference 21\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21938067\" aria-label=\"PubMed reference 21\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3188402\" aria-label=\"PubMed Central reference 21\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Absence%20of%20effects%20of%20Sir2%20overexpression%20on%20lifespan%20in%20C.%20elegans%20and%20Drosophila&amp;journal=Nature&amp;doi=10.1038%2Fnature10296&amp;volume=477&amp;pages=482-485&amp;publication_year=2011&amp;author=Burnett%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"22.\">\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Forster, M. J., Morris, P. &amp; Sohal, R. S. Genotype and age influence the effect of caloric intake on mortality in mice. FASEB J. <b>17<\/b>, 690\u2013692 (2003).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1096\/fj.02-0533fje\" data-track-item_id=\"10.1096\/fj.02-0533fje\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1096%2Ffj.02-0533fje\" aria-label=\"Article reference 22\" data-doi=\"10.1096\/fj.02-0533fje\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12586746\" aria-label=\"PubMed reference 22\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genotype%20and%20age%20influence%20the%20effect%20of%20caloric%20intake%20on%20mortality%20in%20mice&amp;journal=FASEB%20J.&amp;doi=10.1096%2Ffj.02-0533fje&amp;volume=17&amp;pages=690-692&amp;publication_year=2003&amp;author=Forster%2CMJ&amp;author=Morris%2CP&amp;author=Sohal%2CRS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"23.\">\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Speakman, J. R. &amp; Mitchell, S. E. Caloric restriction. Mol. Asp. Med. <b>32<\/b>, 159\u2013221 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mam.2011.07.001\" data-track-item_id=\"10.1016\/j.mam.2011.07.001\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mam.2011.07.001\" aria-label=\"Article reference 23\" data-doi=\"10.1016\/j.mam.2011.07.001\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhtlejsLnO\" aria-label=\"CAS reference 23\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction&amp;journal=Mol.%20Asp.%20Med.&amp;doi=10.1016%2Fj.mam.2011.07.001&amp;volume=32&amp;pages=159-221&amp;publication_year=2011&amp;author=Speakman%2CJR&amp;author=Mitchell%2CSE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"24.\">\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Di Francesco, A. et al. Dietary restriction impacts health and lifespan of genetically diverse mice. Nature <b>634<\/b>, 684\u2013692 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41586-024-08026-3\" data-track-item_id=\"10.1038\/s41586-024-08026-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41586-024-08026-3\" aria-label=\"Article reference 24\" data-doi=\"10.1038\/s41586-024-08026-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39385029\" aria-label=\"PubMed reference 24\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11485257\" aria-label=\"PubMed Central reference 24\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dietary%20restriction%20impacts%20health%20and%20lifespan%20of%20genetically%20diverse%20mice&amp;journal=Nature&amp;doi=10.1038%2Fs41586-024-08026-3&amp;volume=634&amp;pages=684-692&amp;publication_year=2024&amp;author=Francesco%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"25.\">\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Fontana, L., Partridge, L. &amp; Longo, V. D. Extending healthy life span-from yeast to humans. Science <b>328<\/b>, 321\u2013326 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.1172539\" data-track-item_id=\"10.1126\/science.1172539\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.1172539\" aria-label=\"Article reference 25\" data-doi=\"10.1126\/science.1172539\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXks1Snsro%3D\" aria-label=\"CAS reference 25\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20395504\" aria-label=\"PubMed reference 25\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3607354\" aria-label=\"PubMed Central reference 25\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Extending%20healthy%20life%20span-from%20yeast%20to%20humans&amp;journal=Science&amp;doi=10.1126%2Fscience.1172539&amp;volume=328&amp;pages=321-326&amp;publication_year=2010&amp;author=Fontana%2CL&amp;author=Partridge%2CL&amp;author=Longo%2CVD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"26.\">\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Green, C. L. et al. The effects of graded levels of calorie restriction: XVI. Metabolomic changes in the cerebellum indicate activation of hypothalamocerebellar connections driven by hunger responses. J. Gerontol. A Biol. Sci. Med. Sci. <b>76<\/b>, 601\u2013610 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/glaa261\" data-track-item_id=\"10.1093\/gerona\/glaa261\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2Fglaa261\" aria-label=\"Article reference 26\" data-doi=\"10.1093\/gerona\/glaa261\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitVOrsb%2FL\" aria-label=\"CAS reference 26\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33053185\" aria-label=\"PubMed reference 26\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effects%20of%20graded%20levels%20of%20calorie%20restriction%3A%20XVI.%20Metabolomic%20changes%20in%20the%20cerebellum%20indicate%20activation%20of%20hypothalamocerebellar%20connections%20driven%20by%20hunger%20responses&amp;journal=J.%20Gerontol.%20A%20Biol.%20Sci.%20Med.%20Sci.&amp;doi=10.1093%2Fgerona%2Fglaa261&amp;volume=76&amp;pages=601-610&amp;publication_year=2021&amp;author=Green%2CCL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"27.\">\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Dirks, A. J. &amp; Leeuwenburgh, C. Caloric restriction in humans: potential pitfalls and health concerns. Mech. Ageing Dev. <b>127<\/b>, 1\u20137 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mad.2005.09.001\" data-track-item_id=\"10.1016\/j.mad.2005.09.001\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mad.2005.09.001\" aria-label=\"Article reference 27\" data-doi=\"10.1016\/j.mad.2005.09.001\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16226298\" aria-label=\"PubMed reference 27\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20in%20humans%3A%20potential%20pitfalls%20and%20health%20concerns&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2Fj.mad.2005.09.001&amp;volume=127&amp;pages=1-7&amp;publication_year=2006&amp;author=Dirks%2CAJ&amp;author=Leeuwenburgh%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"28.\">\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Guo, S. &amp; Dipietro, L. A. Factors affecting wound healing. J. Dent. Res. <b>89<\/b>, 219\u2013229 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1177\/0022034509359125\" data-track-item_id=\"10.1177\/0022034509359125\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1177%2F0022034509359125\" aria-label=\"Article reference 28\" data-doi=\"10.1177\/0022034509359125\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXjtFOnsLc%3D\" aria-label=\"CAS reference 28\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20139336\" aria-label=\"PubMed reference 28\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2903966\" aria-label=\"PubMed Central reference 28\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Factors%20affecting%20wound%20healing&amp;journal=J.%20Dent.%20Res.&amp;doi=10.1177%2F0022034509359125&amp;volume=89&amp;pages=219-229&amp;publication_year=2010&amp;author=Guo%2CS&amp;author=Dipietro%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"29.\">\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Gosain, A. &amp; DiPietro, L. A. Aging and wound healing. World J. Surg. <b>28<\/b>, 321\u2013326 (2004).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s00268-003-7397-6\" data-track-item_id=\"10.1007\/s00268-003-7397-6\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00268-003-7397-6\" aria-label=\"Article reference 29\" data-doi=\"10.1007\/s00268-003-7397-6\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=14961191\" aria-label=\"PubMed reference 29\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Aging%20and%20wound%20healing&amp;journal=World%20J.%20Surg.&amp;doi=10.1007%2Fs00268-003-7397-6&amp;volume=28&amp;pages=321-326&amp;publication_year=2004&amp;author=Gosain%2CA&amp;author=DiPietro%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"30.\">\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Swift, M. E., Burns, A. L., Gray, K. L. &amp; DiPietro, L. A. Age-related alterations in the inflammatory response to dermal injury. J. Invest. Dermatol. <b>117<\/b>, 1027\u20131035 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1046\/j.0022-202x.2001.01539.x\" data-track-item_id=\"10.1046\/j.0022-202x.2001.01539.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1046%2Fj.0022-202x.2001.01539.x\" aria-label=\"Article reference 30\" data-doi=\"10.1046\/j.0022-202x.2001.01539.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XhtFOlsg%3D%3D\" aria-label=\"CAS reference 30\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11710909\" aria-label=\"PubMed reference 30\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Age-related%20alterations%20in%20the%20inflammatory%20response%20to%20dermal%20injury&amp;journal=J.%20Invest.%20Dermatol.&amp;doi=10.1046%2Fj.0022-202x.2001.01539.x&amp;volume=117&amp;pages=1027-1035&amp;publication_year=2001&amp;author=Swift%2CME&amp;author=Burns%2CAL&amp;author=Gray%2CKL&amp;author=DiPietro%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"31.\">\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Swift, M. E., Kleinman, H. K. &amp; DiPietro, L. A. Impaired wound repair and delayed angiogenesis in aged mice. Lab. Invest. <b>79<\/b>, 1479\u20131487 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3cXlsVCksw%3D%3D\" aria-label=\"CAS reference 31\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10616199\" aria-label=\"PubMed reference 31\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Impaired%20wound%20repair%20and%20delayed%20angiogenesis%20in%20aged%20mice&amp;journal=Lab.%20Invest.&amp;volume=79&amp;pages=1479-1487&amp;publication_year=1999&amp;author=Swift%2CME&amp;author=Kleinman%2CHK&amp;author=DiPietro%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"32.\">\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Barchitta, M. et al. Nutrition and wound healing: an overview focusing on the beneficial effects of curcumin. Int. J. Mol. Sci. <b>20<\/b>, 1119 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms20051119\" data-track-item_id=\"10.3390\/ijms20051119\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms20051119\" aria-label=\"Article reference 32\" data-doi=\"10.3390\/ijms20051119\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhsFOnt7%2FI\" aria-label=\"CAS reference 32\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30841550\" aria-label=\"PubMed reference 32\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6429075\" aria-label=\"PubMed Central reference 32\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Nutrition%20and%20wound%20healing%3A%20an%20overview%20focusing%20on%20the%20beneficial%20effects%20of%20curcumin&amp;journal=Int.%20J.%20Mol.%20Sci.&amp;doi=10.3390%2Fijms20051119&amp;volume=20&amp;publication_year=2019&amp;author=Barchitta%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"33.\">\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Reiser, K., McGee, C., Rucker, R. &amp; McDonald, R. Effects of aging and caloric restriction on extracellular matrix biosynthesis in a model of injury repair in rats. J. Gerontol. A Biol. Sci. Med. Sci. <b>50a<\/b>, B40\u2013B47 (1995).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/50A.1.B40\" data-track-item_id=\"10.1093\/gerona\/50A.1.B40\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2F50A.1.B40\" aria-label=\"Article reference 33\" data-doi=\"10.1093\/gerona\/50A.1.B40\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK2MXmslCgurc%3D\" aria-label=\"CAS reference 33\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=7814778\" aria-label=\"PubMed reference 33\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20aging%20and%20caloric%20restriction%20on%20extracellular%20matrix%20biosynthesis%20in%20a%20model%20of%20injury%20repair%20in%20rats&amp;journal=J.%20Gerontol.%20A%20Biol.%20Sci.%20Med.%20Sci.&amp;doi=10.1093%2Fgerona%2F50A.1.B40&amp;volume=50a&amp;pages=B40-B47&amp;publication_year=1995&amp;author=Reiser%2CK&amp;author=McGee%2CC&amp;author=Rucker%2CR&amp;author=McDonald%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"34.\">\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Harrison, D. E. &amp; Archer, J. R. Genetic differences in effects of food restriction on aging in mice. J. Nutr. <b>117<\/b>, 376\u2013382 (1987).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jn\/117.2.376\" data-track-item_id=\"10.1093\/jn\/117.2.376\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjn%2F117.2.376\" aria-label=\"Article reference 34\" data-doi=\"10.1093\/jn\/117.2.376\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaL2s7mvVOluw%3D%3D\" aria-label=\"CAS reference 34\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=3559752\" aria-label=\"PubMed reference 34\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genetic%20differences%20in%20effects%20of%20food%20restriction%20on%20aging%20in%20mice&amp;journal=J.%20Nutr.&amp;doi=10.1093%2Fjn%2F117.2.376&amp;volume=117&amp;pages=376-382&amp;publication_year=1987&amp;author=Harrison%2CDE&amp;author=Archer%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"35.\">\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Reed, M. J. et al. Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice. Mech. Ageing Dev. <b>89<\/b>, 21\u201343 (1996).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/0047-6374(96)01737-X\" data-track-item_id=\"10.1016\/0047-6374(96)01737-X\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2F0047-6374%2896%2901737-X\" aria-label=\"Article reference 35\" data-doi=\"10.1016\/0047-6374(96)01737-X\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK28vhs1Wqug%3D%3D\" aria-label=\"CAS reference 35\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8819104\" aria-label=\"PubMed reference 35\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Enhanced%20cell%20proliferation%20and%20biosynthesis%20mediate%20improved%20wound%20repair%20in%20refed%2C%20caloric-restricted%20mice&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2F0047-6374%2896%2901737-X&amp;volume=89&amp;pages=21-43&amp;publication_year=1996&amp;author=Reed%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"36.\">\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Hunt, N. D. et al. Effect of calorie restriction and refeeding on skin wound healing in the rat. Age <b>34<\/b>, 1453\u20131458 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s11357-011-9321-6\" data-track-item_id=\"10.1007\/s11357-011-9321-6\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s11357-011-9321-6\" aria-label=\"Article reference 36\" data-doi=\"10.1007\/s11357-011-9321-6\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22037865\" aria-label=\"PubMed reference 36\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20calorie%20restriction%20and%20refeeding%20on%20skin%20wound%20healing%20in%20the%20rat&amp;journal=Age&amp;doi=10.1007%2Fs11357-011-9321-6&amp;volume=34&amp;pages=1453-1458&amp;publication_year=2012&amp;author=Hunt%2CND\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"37.\">\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Wolf, N. S. in The Comparative Biology of Aging (ed. Wolf, N. S.) 97\u2013122 (Springer, 2009).<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"38.\">\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Hsieh, E. A., Chai, C. M. &amp; Hellerstein, M. K. Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding. Am. J. Physiol. Endocrinol. Metab. <b>288<\/b>, E965\u2013E972 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1152\/ajpendo.00368.2004\" data-track-item_id=\"10.1152\/ajpendo.00368.2004\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1152%2Fajpendo.00368.2004\" aria-label=\"Article reference 38\" data-doi=\"10.1152\/ajpendo.00368.2004\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXktlSnsr0%3D\" aria-label=\"CAS reference 38\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15613681\" aria-label=\"PubMed reference 38\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20caloric%20restriction%20on%20cell%20proliferation%20in%20several%20tissues%20in%20mice%3A%20role%20of%20intermittent%20feeding&amp;journal=Am.%20J.%20Physiol.%20Endocrinol.%20Metab.&amp;doi=10.1152%2Fajpendo.00368.2004&amp;volume=288&amp;pages=E965-E972&amp;publication_year=2005&amp;author=Hsieh%2CEA&amp;author=Chai%2CCM&amp;author=Hellerstein%2CMK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"39.\">\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Iwamura, H. et al. Caloric restriction reduces basal cell proliferation and results in the deterioration of neuroepithelial regeneration following olfactotoxic mucosal damage in mouse olfactory mucosa. Cell Tissue Res. <b>378<\/b>, 175\u2013193 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s00441-019-03047-1\" data-track-item_id=\"10.1007\/s00441-019-03047-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00441-019-03047-1\" aria-label=\"Article reference 39\" data-doi=\"10.1007\/s00441-019-03047-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtFWltLvF\" aria-label=\"CAS reference 39\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31168693\" aria-label=\"PubMed reference 39\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20reduces%20basal%20cell%20proliferation%20and%20results%20in%20the%20deterioration%20of%20neuroepithelial%20regeneration%20following%20olfactotoxic%20mucosal%20damage%20in%20mouse%20olfactory%20mucosa&amp;journal=Cell%20Tissue%20Res.&amp;doi=10.1007%2Fs00441-019-03047-1&amp;volume=378&amp;pages=175-193&amp;publication_year=2019&amp;author=Iwamura%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"40.\">\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Roth, G. S. et al. Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys. J. Gerontol. A Biol. Sci. Med. Sci. <b>52<\/b>, B98\u2013B102 (1997).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/52A.2.B98\" data-track-item_id=\"10.1093\/gerona\/52A.2.B98\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2F52A.2.B98\" aria-label=\"Article reference 40\" data-doi=\"10.1093\/gerona\/52A.2.B98\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK2s3hsVGrtA%3D%3D\" aria-label=\"CAS reference 40\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9060966\" aria-label=\"PubMed reference 40\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20age%20and%20caloric%20restriction%20on%20cutaneous%20wound%20closure%20in%20rats%20and%20monkeys&amp;journal=J.%20Gerontol.%20A%20Biol.%20Sci.%20Med.%20Sci.&amp;doi=10.1093%2Fgerona%2F52A.2.B98&amp;volume=52&amp;pages=B98-B102&amp;publication_year=1997&amp;author=Roth%2CGS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"41.\">\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Weindruch, R. H., Kristie, J. A., Cheney, K. E. &amp; Walford, R. L. Influence of controlled dietary restriction on immunologic function and aging. Fed. Proc. <b>38<\/b>, 2007\u20132016 (1979).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaE1M7mvF2gtw%3D%3D\" aria-label=\"CAS reference 41\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=437143\" aria-label=\"PubMed reference 41\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Influence%20of%20controlled%20dietary%20restriction%20on%20immunologic%20function%20and%20aging&amp;journal=Fed.%20Proc.&amp;volume=38&amp;pages=2007-2016&amp;publication_year=1979&amp;author=Weindruch%2CRH&amp;author=Kristie%2CJA&amp;author=Cheney%2CKE&amp;author=Walford%2CRL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"42.\">\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Carrillo, A. E. &amp; Flouris, A. D. Caloric restriction and longevity: effects of reduced body temperature. Ageing Res. Rev. <b>10<\/b>, 153\u2013162 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.arr.2010.10.001\" data-track-item_id=\"10.1016\/j.arr.2010.10.001\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.arr.2010.10.001\" aria-label=\"Article reference 42\" data-doi=\"10.1016\/j.arr.2010.10.001\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20969980\" aria-label=\"PubMed reference 42\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20and%20longevity%3A%20effects%20of%20reduced%20body%20temperature&amp;journal=Ageing%20Res.%20Rev.&amp;doi=10.1016%2Fj.arr.2010.10.001&amp;volume=10&amp;pages=153-162&amp;publication_year=2011&amp;author=Carrillo%2CAE&amp;author=Flouris%2CAD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"43.\">\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Lane, M. A. et al. Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc. Natl Acad. Sci. USA <b>93<\/b>, 4159\u20134164 (1996).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1073\/pnas.93.9.4159\" data-track-item_id=\"10.1073\/pnas.93.9.4159\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1073%2Fpnas.93.9.4159\" aria-label=\"Article reference 43\" data-doi=\"10.1073\/pnas.93.9.4159\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK28XivVKqsrk%3D\" aria-label=\"CAS reference 43\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8633033\" aria-label=\"PubMed reference 43\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC39504\" aria-label=\"PubMed Central reference 43\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20lowers%20body%20temperature%20in%20rhesus%20monkeys%2C%20consistent%20with%20a%20postulated%20anti-aging%20mechanism%20in%20rodents&amp;journal=Proc.%20Natl%20Acad.%20Sci.%20USA&amp;doi=10.1073%2Fpnas.93.9.4159&amp;volume=93&amp;pages=4159-4164&amp;publication_year=1996&amp;author=Lane%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"44.\">\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Mitchell, S. E. et al. The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL\/6 mouse. Oncotarget <b>6<\/b>, 18314\u201318337 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.18632\/oncotarget.4506\" data-track-item_id=\"10.18632\/oncotarget.4506\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.18632%2Foncotarget.4506\" aria-label=\"Article reference 44\" data-doi=\"10.18632\/oncotarget.4506\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26286956\" aria-label=\"PubMed reference 44\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4621893\" aria-label=\"PubMed Central reference 44\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effects%20of%20graded%20levels%20of%20calorie%20restriction%3A%20III.%20Impact%20of%20short%20term%20calorie%20and%20protein%20restriction%20on%20mean%20daily%20body%20temperature%20and%20torpor%20use%20in%20the%20C57BL%2F6%20mouse&amp;journal=Oncotarget&amp;doi=10.18632%2Foncotarget.4506&amp;volume=6&amp;pages=18314-18337&amp;publication_year=2015&amp;author=Mitchell%2CSE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"45.\">\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Forsum, E., Hillman, P. E. &amp; Nesheim, M. C. Effect of energy restriction on total heat production, basal metabolic rate, and specific dynamic action of food in rats. J. Nutr. <b>111<\/b>, 1691\u20131697 (1981).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jn\/111.10.1691\" data-track-item_id=\"10.1093\/jn\/111.10.1691\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjn%2F111.10.1691\" aria-label=\"Article reference 45\" data-doi=\"10.1093\/jn\/111.10.1691\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaL3MXmtVant7s%3D\" aria-label=\"CAS reference 45\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=6793699\" aria-label=\"PubMed reference 45\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20energy%20restriction%20on%20total%20heat%20production%2C%20basal%20metabolic%20rate%2C%20and%20specific%20dynamic%20action%20of%20food%20in%20rats&amp;journal=J.%20Nutr.&amp;doi=10.1093%2Fjn%2F111.10.1691&amp;volume=111&amp;pages=1691-1697&amp;publication_year=1981&amp;author=Forsum%2CE&amp;author=Hillman%2CPE&amp;author=Nesheim%2CMC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"46.\">\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Hambly, C. &amp; Speakman, J. R. Contribution of different mechanisms to compensation for energy restriction in the mouse. Obes. Res. <b>13<\/b>, 1548\u20131557 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/oby.2005.190\" data-track-item_id=\"10.1038\/oby.2005.190\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Foby.2005.190\" aria-label=\"Article reference 46\" data-doi=\"10.1038\/oby.2005.190\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16222057\" aria-label=\"PubMed reference 46\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Contribution%20of%20different%20mechanisms%20to%20compensation%20for%20energy%20restriction%20in%20the%20mouse&amp;journal=Obes.%20Res.&amp;doi=10.1038%2Foby.2005.190&amp;volume=13&amp;pages=1548-1557&amp;publication_year=2005&amp;author=Hambly%2CC&amp;author=Speakman%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"47.\">\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Rikke, B. A. et al. Strain variation in the response of body temperature to dietary restriction. Mech. Ageing Dev. <b>124<\/b>, 663\u2013678 (2003).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0047-6374(03)00003-4\" data-track-item_id=\"10.1016\/S0047-6374(03)00003-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0047-6374%2803%2900003-4\" aria-label=\"Article reference 47\" data-doi=\"10.1016\/S0047-6374(03)00003-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12735906\" aria-label=\"PubMed reference 47\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Strain%20variation%20in%20the%20response%20of%20body%20temperature%20to%20dietary%20restriction&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2FS0047-6374%2803%2900003-4&amp;volume=124&amp;pages=663-678&amp;publication_year=2003&amp;author=Rikke%2CBA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"48.\">\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Turturro, A. &amp; Hart, R. W. Longevity-assurance mechanisms and caloric restriction. Ann. N. Y. Acad. Sci. <b>621<\/b>, 363\u2013372 (1991).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1749-6632.1991.tb16992.x\" data-track-item_id=\"10.1111\/j.1749-6632.1991.tb16992.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1749-6632.1991.tb16992.x\" aria-label=\"Article reference 48\" data-doi=\"10.1111\/j.1749-6632.1991.tb16992.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK3MzhsFSmtQ%3D%3D\" aria-label=\"CAS reference 48\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1859096\" aria-label=\"PubMed reference 48\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Longevity-assurance%20mechanisms%20and%20caloric%20restriction&amp;journal=Ann.%20N.%20Y.%20Acad.%20Sci.&amp;doi=10.1111%2Fj.1749-6632.1991.tb16992.x&amp;volume=621&amp;pages=363-372&amp;publication_year=1991&amp;author=Turturro%2CA&amp;author=Hart%2CRW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"49.\">\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Hunter, W. S., Croson, W. B., Bartke, A., Gentry, M. V. &amp; Meliska, C. J. Low body temperature in long-lived Ames dwarf mice at rest and during stress. Physiol. Behav. <b>67<\/b>, 433\u2013437 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0031-9384(99)00098-0\" data-track-item_id=\"10.1016\/S0031-9384(99)00098-0\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0031-9384%2899%2900098-0\" aria-label=\"Article reference 49\" data-doi=\"10.1016\/S0031-9384(99)00098-0\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXmtlGrs70%3D\" aria-label=\"CAS reference 49\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10497963\" aria-label=\"PubMed reference 49\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Low%20body%20temperature%20in%20long-lived%20Ames%20dwarf%20mice%20at%20rest%20and%20during%20stress&amp;journal=Physiol.%20Behav.&amp;doi=10.1016%2FS0031-9384%2899%2900098-0&amp;volume=67&amp;pages=433-437&amp;publication_year=1999&amp;author=Hunter%2CWS&amp;author=Croson%2CWB&amp;author=Bartke%2CA&amp;author=Gentry%2CMV&amp;author=Meliska%2CCJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"50.\">\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Conti, B. et al. Transgenic mice with a reduced core body temperature have an increased life span. Science <b>314<\/b>, 825\u2013828 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.1132191\" data-track-item_id=\"10.1126\/science.1132191\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.1132191\" aria-label=\"Article reference 50\" data-doi=\"10.1126\/science.1132191\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XhtFKit73O\" aria-label=\"CAS reference 50\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17082459\" aria-label=\"PubMed reference 50\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transgenic%20mice%20with%20a%20reduced%20core%20body%20temperature%20have%20an%20increased%20life%20span&amp;journal=Science&amp;doi=10.1126%2Fscience.1132191&amp;volume=314&amp;pages=825-828&amp;publication_year=2006&amp;author=Conti%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"51.\">\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Zhao, Z. et al. Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals. Nat. Metab. <b>4<\/b>, 320\u2013326 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s42255-022-00545-5\" data-track-item_id=\"10.1038\/s42255-022-00545-5\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs42255-022-00545-5\" aria-label=\"Article reference 51\" data-doi=\"10.1038\/s42255-022-00545-5\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XotFKrtrg%3D\" aria-label=\"CAS reference 51\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35288719\" aria-label=\"PubMed reference 51\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 51\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Body%20temperature%20is%20a%20more%20important%20modulator%20of%20lifespan%20than%20metabolic%20rate%20in%20two%20small%20mammals&amp;journal=Nat.%20Metab.&amp;doi=10.1038%2Fs42255-022-00545-5&amp;volume=4&amp;pages=320-326&amp;publication_year=2022&amp;author=Zhao%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"52.\">\n<p class=\"c-article-references__text\" id=\"ref-CR52\">Hauck, S. J., Hunter, W. S., Danilovich, N., Kopchick, J. J. &amp; Bartke, A. Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor\/binding protein knockout mouse. Exp. Biol. Med. <b>226<\/b>, 552\u2013558 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1177\/153537020122600607\" data-track-item_id=\"10.1177\/153537020122600607\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1177%2F153537020122600607\" aria-label=\"Article reference 52\" data-doi=\"10.1177\/153537020122600607\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXktVajtLo%3D\" aria-label=\"CAS reference 52\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 52\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reduced%20levels%20of%20thyroid%20hormones%2C%20insulin%2C%20and%20glucose%2C%20and%20lower%20body%20core%20temperature%20in%20the%20growth%20hormone%20receptor%2Fbinding%20protein%20knockout%20mouse&amp;journal=Exp.%20Biol.%20Med.&amp;doi=10.1177%2F153537020122600607&amp;volume=226&amp;pages=552-558&amp;publication_year=2001&amp;author=Hauck%2CSJ&amp;author=Hunter%2CWS&amp;author=Danilovich%2CN&amp;author=Kopchick%2CJJ&amp;author=Bartke%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"53.\">\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Cintron-Colon, R., Shankar, K., Sanchez-Alavez, M. &amp; Conti, B. Gonadal hormones influence core body temperature during calorie restriction. Temperature <b>6<\/b>, 158\u2013168 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1080\/23328940.2019.1607653\" data-track-item_id=\"10.1080\/23328940.2019.1607653\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1080%2F23328940.2019.1607653\" aria-label=\"Article reference 53\" data-doi=\"10.1080\/23328940.2019.1607653\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 53\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gonadal%20hormones%20influence%20core%20body%20temperature%20during%20calorie%20restriction&amp;journal=Temperature&amp;doi=10.1080%2F23328940.2019.1607653&amp;volume=6&amp;pages=158-168&amp;publication_year=2019&amp;author=Cintron-Colon%2CR&amp;author=Shankar%2CK&amp;author=Sanchez-Alavez%2CM&amp;author=Conti%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"54.\">\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Johnstone, A. M., Murison, S. D., Duncan, J. S., Rance, K. A. &amp; Speakman, J. R. Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. Am. J. Clin. Nutr. <b>82<\/b>, 941\u2013948 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/ajcn\/82.5.941\" data-track-item_id=\"10.1093\/ajcn\/82.5.941\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fajcn%2F82.5.941\" aria-label=\"Article reference 54\" data-doi=\"10.1093\/ajcn\/82.5.941\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXht1ektLnO\" aria-label=\"CAS reference 54\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16280423\" aria-label=\"PubMed reference 54\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Factors%20influencing%20variation%20in%20basal%20metabolic%20rate%20include%20fat-free%20mass%2C%20fat%20mass%2C%20age%2C%20and%20circulating%20thyroxine%20but%20not%20sex%2C%20circulating%20leptin%2C%20or%20triiodothyronine&amp;journal=Am.%20J.%20Clin.%20Nutr.&amp;doi=10.1093%2Fajcn%2F82.5.941&amp;volume=82&amp;pages=941-948&amp;publication_year=2005&amp;author=Johnstone%2CAM&amp;author=Murison%2CSD&amp;author=Duncan%2CJS&amp;author=Rance%2CKA&amp;author=Speakman%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"55.\">\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Roth, G. S. et al. Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeys. Horm. Metab. Res. <b>34<\/b>, 378\u2013382 (2002).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1055\/s-2002-33469\" data-track-item_id=\"10.1055\/s-2002-33469\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1055%2Fs-2002-33469\" aria-label=\"Article reference 55\" data-doi=\"10.1055\/s-2002-33469\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XmsVSht70%3D\" aria-label=\"CAS reference 55\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12189585\" aria-label=\"PubMed reference 55\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20dietary%20caloric%20restriction%20and%20aging%20on%20thyroid%20hormones%20of%20rhesus%20monkeys&amp;journal=Horm.%20Metab.%20Res.&amp;doi=10.1055%2Fs-2002-33469&amp;volume=34&amp;pages=378-382&amp;publication_year=2002&amp;author=Roth%2CGS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"56.\">\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Fontana, L., Klein, S., Holloszy, J. O. &amp; Premachandra, B. N. Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. J. Clin. Endocrinol. Metab. <b>91<\/b>, 3232\u20133235 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1210\/jc.2006-0328\" data-track-item_id=\"10.1210\/jc.2006-0328\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1210%2Fjc.2006-0328\" aria-label=\"Article reference 56\" data-doi=\"10.1210\/jc.2006-0328\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XosFGhtLo%3D\" aria-label=\"CAS reference 56\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16720655\" aria-label=\"PubMed reference 56\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20long-term%20calorie%20restriction%20with%20adequate%20protein%20and%20micronutrients%20on%20thyroid%20hormones&amp;journal=J.%20Clin.%20Endocrinol.%20Metab.&amp;doi=10.1210%2Fjc.2006-0328&amp;volume=91&amp;pages=3232-3235&amp;publication_year=2006&amp;author=Fontana%2CL&amp;author=Klein%2CS&amp;author=Holloszy%2CJO&amp;author=Premachandra%2CBN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"57.\">\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Cintron-Colon, R. et al. Activation of kappa opioid receptor regulates the hypothermic response to calorie restriction and limits body weight loss. Curr. Biol. <b>29<\/b>, 4291\u20134299 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.cub.2019.10.027\" data-track-item_id=\"10.1016\/j.cub.2019.10.027\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.cub.2019.10.027\" aria-label=\"Article reference 57\" data-doi=\"10.1016\/j.cub.2019.10.027\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXit12ksLnP\" aria-label=\"CAS reference 57\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31786059\" aria-label=\"PubMed reference 57\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6917995\" aria-label=\"PubMed Central reference 57\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20of%20kappa%20opioid%20receptor%20regulates%20the%20hypothermic%20response%20to%20calorie%20restriction%20and%20limits%20body%20weight%20loss&amp;journal=Curr.%20Biol.&amp;doi=10.1016%2Fj.cub.2019.10.027&amp;volume=29&amp;pages=4291-4299&amp;publication_year=2019&amp;author=Cintron-Colon%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"58.\">\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Sheng, Y. et al. Differential responses of white adipose tissue and brown adipose tissue to calorie restriction during aging. J. Gerontol. A Biol. Sci. Med. Sci. <b>76<\/b>, 393\u2013399 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/glaa070\" data-track-item_id=\"10.1093\/gerona\/glaa070\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2Fglaa070\" aria-label=\"Article reference 58\" data-doi=\"10.1093\/gerona\/glaa070\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXnvFygsbw%3D\" aria-label=\"CAS reference 58\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32222773\" aria-label=\"PubMed reference 58\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Differential%20responses%20of%20white%20adipose%20tissue%20and%20brown%20adipose%20tissue%20to%20calorie%20restriction%20during%20aging&amp;journal=J.%20Gerontol.%20A%20Biol.%20Sci.%20Med.%20Sci.&amp;doi=10.1093%2Fgerona%2Fglaa070&amp;volume=76&amp;pages=393-399&amp;publication_year=2021&amp;author=Sheng%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"59.\">\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Selman, C. et al. Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mech. Ageing Dev. <b>126<\/b>, 783\u2013793 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mad.2005.02.004\" data-track-item_id=\"10.1016\/j.mad.2005.02.004\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mad.2005.02.004\" aria-label=\"Article reference 59\" data-doi=\"10.1016\/j.mad.2005.02.004\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15888333\" aria-label=\"PubMed reference 59\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Energy%20expenditure%20of%20calorically%20restricted%20rats%20is%20higher%20than%20predicted%20from%20their%20altered%20body%20composition&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2Fj.mad.2005.02.004&amp;volume=126&amp;pages=783-793&amp;publication_year=2005&amp;author=Selman%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"60.\">\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Duffy, P. H., Feuers, R. J. &amp; Hart, R. W. Effect of chronic caloric restriction on the circadian regulation of physiological and behavioral variables in old male B6C3F1 mice. Chronobiol. Int. <b>7<\/b>, 291\u2013303 (1990).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1080\/07420529009064635\" data-track-item_id=\"10.1080\/07420529009064635\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1080%2F07420529009064635\" aria-label=\"Article reference 60\" data-doi=\"10.1080\/07420529009064635\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK3M7pvFaqtA%3D%3D\" aria-label=\"CAS reference 60\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2085870\" aria-label=\"PubMed reference 60\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 60\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20chronic%20caloric%20restriction%20on%20the%20circadian%20regulation%20of%20physiological%20and%20behavioral%20variables%20in%20old%20male%20B6C3F1%20mice&amp;journal=Chronobiol.%20Int.&amp;doi=10.1080%2F07420529009064635&amp;volume=7&amp;pages=291-303&amp;publication_year=1990&amp;author=Duffy%2CPH&amp;author=Feuers%2CRJ&amp;author=Hart%2CRW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"61.\">\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Hebebrand, J. et al. Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol. Behav. <b>79<\/b>, 25\u201337 (2003).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0031-9384(03)00102-1\" data-track-item_id=\"10.1016\/S0031-9384(03)00102-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0031-9384%2803%2900102-1\" aria-label=\"Article reference 61\" data-doi=\"10.1016\/S0031-9384(03)00102-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXks1eisro%3D\" aria-label=\"CAS reference 61\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12818707\" aria-label=\"PubMed reference 61\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hyperactivity%20in%20patients%20with%20anorexia%20nervosa%20and%20in%20semistarved%20rats%3A%20evidence%20for%20a%20pivotal%20role%20of%20hypoleptinemia&amp;journal=Physiol.%20Behav.&amp;doi=10.1016%2FS0031-9384%2803%2900102-1&amp;volume=79&amp;pages=25-37&amp;publication_year=2003&amp;author=Hebebrand%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"62.\">\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Duffy, P. H., Feuers, R., Nakamura, K. D., Leakey, J. &amp; Hart, R. W. Effect of chronic caloric restriction on the synchronization of various physiological measures in old female Fischer 344 rats. Chronobiol. Int. <b>7<\/b>, 113\u2013124 (1990).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3109\/07420529009056963\" data-track-item_id=\"10.3109\/07420529009056963\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3109%2F07420529009056963\" aria-label=\"Article reference 62\" data-doi=\"10.3109\/07420529009056963\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK3M%2FlsFamsw%3D%3D\" aria-label=\"CAS reference 62\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2242505\" aria-label=\"PubMed reference 62\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20chronic%20caloric%20restriction%20on%20the%20synchronization%20of%20various%20physiological%20measures%20in%20old%20female%20Fischer%20344%20rats&amp;journal=Chronobiol.%20Int.&amp;doi=10.3109%2F07420529009056963&amp;volume=7&amp;pages=113-124&amp;publication_year=1990&amp;author=Duffy%2CPH&amp;author=Feuers%2CR&amp;author=Nakamura%2CKD&amp;author=Leakey%2CJ&amp;author=Hart%2CRW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"63.\">\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Ahima, R. S. &amp; Antwi, D. A. Brain regulation of appetite and satiety. Endocrinol. Metab. Clin. North Am. <b>37<\/b>, 811\u2013823 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.ecl.2008.08.005\" data-track-item_id=\"10.1016\/j.ecl.2008.08.005\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.ecl.2008.08.005\" aria-label=\"Article reference 63\" data-doi=\"10.1016\/j.ecl.2008.08.005\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhsV2hu7k%3D\" aria-label=\"CAS reference 63\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19026933\" aria-label=\"PubMed reference 63\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2710609\" aria-label=\"PubMed Central reference 63\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 63\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Brain%20regulation%20of%20appetite%20and%20satiety&amp;journal=Endocrinol.%20Metab.%20Clin.%20North%20Am.&amp;doi=10.1016%2Fj.ecl.2008.08.005&amp;volume=37&amp;pages=811-823&amp;publication_year=2008&amp;author=Ahima%2CRS&amp;author=Antwi%2CDA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"64.\">\n<p class=\"c-article-references__text\" id=\"ref-CR64\">Luquet, S., Perez, F. A., Hnasko, T. S. &amp; Palmiter, R. D. NPY\/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science <b>310<\/b>, 683\u2013685 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.1115524\" data-track-item_id=\"10.1126\/science.1115524\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.1115524\" aria-label=\"Article reference 64\" data-doi=\"10.1126\/science.1115524\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXhtFChsLjI\" aria-label=\"CAS reference 64\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16254186\" aria-label=\"PubMed reference 64\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 64\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=NPY%2FAgRP%20neurons%20are%20essential%20for%20feeding%20in%20adult%20mice%20but%20can%20be%20ablated%20in%20neonates&amp;journal=Science&amp;doi=10.1126%2Fscience.1115524&amp;volume=310&amp;pages=683-685&amp;publication_year=2005&amp;author=Luquet%2CS&amp;author=Perez%2CFA&amp;author=Hnasko%2CTS&amp;author=Palmiter%2CRD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"65.\">\n<p class=\"c-article-references__text\" id=\"ref-CR65\">Myers, M. G. Jr. &amp; Olson, D. P. Central nervous system control of metabolism. Nature <b>491<\/b>, 357\u2013363 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nature11705\" data-track-item_id=\"10.1038\/nature11705\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnature11705\" aria-label=\"Article reference 65\" data-doi=\"10.1038\/nature11705\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xhs1OgsrzK\" aria-label=\"CAS reference 65\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23151578\" aria-label=\"PubMed reference 65\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 65\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20nervous%20system%20control%20of%20metabolism&amp;journal=Nature&amp;doi=10.1038%2Fnature11705&amp;volume=491&amp;pages=357-363&amp;publication_year=2012&amp;author=Myers%2CMG&amp;author=Olson%2CDP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"66.\">\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Schwartz, M. W., Woods, S. C., Porte, D. Jr., Seeley, R. J. &amp; Baskin, D. G. Central nervous system control of food intake. Nature <b>404<\/b>, 661\u2013671 (2000).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/35007534\" data-track-item_id=\"10.1038\/35007534\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2F35007534\" aria-label=\"Article reference 66\" data-doi=\"10.1038\/35007534\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3cXis1Grur4%3D\" aria-label=\"CAS reference 66\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10766253\" aria-label=\"PubMed reference 66\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 66\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20nervous%20system%20control%20of%20food%20intake&amp;journal=Nature&amp;doi=10.1038%2F35007534&amp;volume=404&amp;pages=661-671&amp;publication_year=2000&amp;author=Schwartz%2CMW&amp;author=Woods%2CSC&amp;author=Porte%2CD&amp;author=Seeley%2CRJ&amp;author=Baskin%2CDG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"67.\">\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Sohn, J. W. Network of hypothalamic neurons that control appetite. BMB Rep. <b>48<\/b>, 229\u2013233 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.5483\/BMBRep.2015.48.4.272\" data-track-item_id=\"10.5483\/BMBRep.2015.48.4.272\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.5483%2FBMBRep.2015.48.4.272\" aria-label=\"Article reference 67\" data-doi=\"10.5483\/BMBRep.2015.48.4.272\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtlCns73F\" aria-label=\"CAS reference 67\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25560696\" aria-label=\"PubMed reference 67\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4436859\" aria-label=\"PubMed Central reference 67\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 67\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Network%20of%20hypothalamic%20neurons%20that%20control%20appetite&amp;journal=BMB%20Rep.&amp;doi=10.5483%2FBMBRep.2015.48.4.272&amp;volume=48&amp;pages=229-233&amp;publication_year=2015&amp;author=Sohn%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"68.\">\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Bruning, J. C. &amp; Fenselau, H. Integrative neurocircuits that control metabolism and food intake. Science <b>381<\/b>, eabl7398 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.abl7398\" data-track-item_id=\"10.1126\/science.abl7398\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.abl7398\" aria-label=\"Article reference 68\" data-doi=\"10.1126\/science.abl7398\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37769095\" aria-label=\"PubMed reference 68\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 68\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Integrative%20neurocircuits%20that%20control%20metabolism%20and%20food%20intake&amp;journal=Science&amp;doi=10.1126%2Fscience.abl7398&amp;volume=381&amp;publication_year=2023&amp;author=Bruning%2CJC&amp;author=Fenselau%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"69.\">\n<p class=\"c-article-references__text\" id=\"ref-CR69\">De Solis, A. J. et al. Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nat. Metab. <b>6<\/b>, 473\u2013493 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s42255-024-00987-z\" data-track-item_id=\"10.1038\/s42255-024-00987-z\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs42255-024-00987-z\" aria-label=\"Article reference 69\" data-doi=\"10.1038\/s42255-024-00987-z\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38378998\" aria-label=\"PubMed reference 69\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10963273\" aria-label=\"PubMed Central reference 69\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 69\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reciprocal%20activity%20of%20AgRP%20and%20POMC%20neurons%20governs%20coordinated%20control%20of%20feeding%20and%20metabolism&amp;journal=Nat.%20Metab.&amp;doi=10.1038%2Fs42255-024-00987-z&amp;volume=6&amp;pages=473-493&amp;publication_year=2024&amp;author=Solis%2CAJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"70.\">\n<p class=\"c-article-references__text\" id=\"ref-CR70\">Fenselau, H. et al. A rapidly acting glutamatergic ARC-&gt;PVH satiety circuit postsynaptically regulated by alpha-MSH. Nat. Neurosci. <b>20<\/b>, 42\u201351 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nn.4442\" data-track-item_id=\"10.1038\/nn.4442\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnn.4442\" aria-label=\"Article reference 70\" data-doi=\"10.1038\/nn.4442\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhvFShtrnN\" aria-label=\"CAS reference 70\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27869800\" aria-label=\"PubMed reference 70\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 70\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20rapidly%20acting%20glutamatergic%20ARC-%3EPVH%20satiety%20circuit%20postsynaptically%20regulated%20by%20alpha-MSH&amp;journal=Nat.%20Neurosci.&amp;doi=10.1038%2Fnn.4442&amp;volume=20&amp;pages=42-51&amp;publication_year=2017&amp;author=Fenselau%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"71.\">\n<p class=\"c-article-references__text\" id=\"ref-CR71\">Andermann, M. L. &amp; Lowell, B. B. Toward a wiring diagram understanding of appetite control. Neuron <b>95<\/b>, 757\u2013778 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.neuron.2017.06.014\" data-track-item_id=\"10.1016\/j.neuron.2017.06.014\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.neuron.2017.06.014\" aria-label=\"Article reference 71\" data-doi=\"10.1016\/j.neuron.2017.06.014\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtlClur3M\" aria-label=\"CAS reference 71\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28817798\" aria-label=\"PubMed reference 71\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5657399\" aria-label=\"PubMed Central reference 71\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 71\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Toward%20a%20wiring%20diagram%20understanding%20of%20appetite%20control&amp;journal=Neuron&amp;doi=10.1016%2Fj.neuron.2017.06.014&amp;volume=95&amp;pages=757-778&amp;publication_year=2017&amp;author=Andermann%2CML&amp;author=Lowell%2CBB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"72.\">\n<p class=\"c-article-references__text\" id=\"ref-CR72\">Hambly, C., Mercer, J. G. &amp; Speakman, J. R. Hunger does not diminish over time in mice under protracted caloric restriction. Rejuvenation Res. <b>10<\/b>, 533\u2013542 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1089\/rej.2007.0555\" data-track-item_id=\"10.1089\/rej.2007.0555\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1089%2Frej.2007.0555\" aria-label=\"Article reference 72\" data-doi=\"10.1089\/rej.2007.0555\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17990972\" aria-label=\"PubMed reference 72\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 72\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hunger%20does%20not%20diminish%20over%20time%20in%20mice%20under%20protracted%20caloric%20restriction&amp;journal=Rejuvenation%20Res.&amp;doi=10.1089%2Frej.2007.0555&amp;volume=10&amp;pages=533-542&amp;publication_year=2007&amp;author=Hambly%2CC&amp;author=Mercer%2CJG&amp;author=Speakman%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"73.\">\n<p class=\"c-article-references__text\" id=\"ref-CR73\">Derous, D. et al. The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways. Aging <b>8<\/b>, 642\u2013663 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.18632\/aging.100895\" data-track-item_id=\"10.18632\/aging.100895\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.18632%2Faging.100895\" aria-label=\"Article reference 73\" data-doi=\"10.18632\/aging.100895\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXmsVymuro%3D\" aria-label=\"CAS reference 73\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26945906\" aria-label=\"PubMed reference 73\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4925820\" aria-label=\"PubMed Central reference 73\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 73\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effects%20of%20graded%20levels%20of%20calorie%20restriction%3A%20VI.%20Impact%20of%20short-term%20graded%20calorie%20restriction%20on%20transcriptomic%20responses%20of%20the%20hypothalamic%20hunger%20and%20circadian%20signaling%20pathways&amp;journal=Aging&amp;doi=10.18632%2Faging.100895&amp;volume=8&amp;pages=642-663&amp;publication_year=2016&amp;author=Derous%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"74.\">\n<p class=\"c-article-references__text\" id=\"ref-CR74\">Maclean, P. S., Bergouignan, A., Cornier, M. A. &amp; Jackman, M. R. Biology\u2019s response to dieting: the impetus for weight regain. Am. J. Physiol. Regul. Integr. Comp. Physiol. <b>301<\/b>, R581\u2013R600 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1152\/ajpregu.00755.2010\" data-track-item_id=\"10.1152\/ajpregu.00755.2010\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1152%2Fajpregu.00755.2010\" aria-label=\"Article reference 74\" data-doi=\"10.1152\/ajpregu.00755.2010\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1SkurjF\" aria-label=\"CAS reference 74\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21677272\" aria-label=\"PubMed reference 74\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3174765\" aria-label=\"PubMed Central reference 74\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 74\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Biology%E2%80%99s%20response%20to%20dieting%3A%20the%20impetus%20for%20weight%20regain&amp;journal=Am.%20J.%20Physiol.%20Regul.%20Integr.%20Comp.%20Physiol.&amp;doi=10.1152%2Fajpregu.00755.2010&amp;volume=301&amp;pages=R581-R600&amp;publication_year=2011&amp;author=Maclean%2CPS&amp;author=Bergouignan%2CA&amp;author=Cornier%2CMA&amp;author=Jackman%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"75.\">\n<p class=\"c-article-references__text\" id=\"ref-CR75\">Polidori, D., Sanghvi, A., Seeley, R. J. &amp; Hall, K. D. How strongly does appetite counter weight loss? Quantification of the feedback control of human energy intake. Obesity <b>24<\/b>, 2289\u20132295 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/oby.21653\" data-track-item_id=\"10.1002\/oby.21653\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Foby.21653\" aria-label=\"Article reference 75\" data-doi=\"10.1002\/oby.21653\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhslOqurzP\" aria-label=\"CAS reference 75\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27804272\" aria-label=\"PubMed reference 75\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 75\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=How%20strongly%20does%20appetite%20counter%20weight%20loss%3F%20Quantification%20of%20the%20feedback%20control%20of%20human%20energy%20intake&amp;journal=Obesity&amp;doi=10.1002%2Foby.21653&amp;volume=24&amp;pages=2289-2295&amp;publication_year=2016&amp;author=Polidori%2CD&amp;author=Sanghvi%2CA&amp;author=Seeley%2CRJ&amp;author=Hall%2CKD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"76.\">\n<p class=\"c-article-references__text\" id=\"ref-CR76\">Dorling, J. L. et al. Change in self-efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity. Appetite <b>143<\/b>, 104397 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.appet.2019.104397\" data-track-item_id=\"10.1016\/j.appet.2019.104397\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.appet.2019.104397\" aria-label=\"Article reference 76\" data-doi=\"10.1016\/j.appet.2019.104397\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31398376\" aria-label=\"PubMed reference 76\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6766406\" aria-label=\"PubMed Central reference 76\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 76\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Change%20in%20self-efficacy%2C%20eating%20behaviors%20and%20food%20cravings%20during%20two%20years%20of%20calorie%20restriction%20in%20humans%20without%20obesity&amp;journal=Appetite&amp;doi=10.1016%2Fj.appet.2019.104397&amp;volume=143&amp;publication_year=2019&amp;author=Dorling%2CJL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"77.\">\n<p class=\"c-article-references__text\" id=\"ref-CR77\">Kahathuduwa, C. N., Binks, M., Martin, C. K. &amp; Dawson, J. A. Extended calorie restriction suppresses overall and specific food cravings: a systematic review and a meta-analysis. Obes. Rev. <b>18<\/b>, 1122\u20131135 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/obr.12566\" data-track-item_id=\"10.1111\/obr.12566\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fobr.12566\" aria-label=\"Article reference 77\" data-doi=\"10.1111\/obr.12566\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BC1cnisFGntQ%3D%3D\" aria-label=\"CAS reference 77\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28557246\" aria-label=\"PubMed reference 77\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6226249\" aria-label=\"PubMed Central reference 77\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 77\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Extended%20calorie%20restriction%20suppresses%20overall%20and%20specific%20food%20cravings%3A%20a%20systematic%20review%20and%20a%20meta-analysis&amp;journal=Obes.%20Rev.&amp;doi=10.1111%2Fobr.12566&amp;volume=18&amp;pages=1122-1135&amp;publication_year=2017&amp;author=Kahathuduwa%2CCN&amp;author=Binks%2CM&amp;author=Martin%2CCK&amp;author=Dawson%2CJA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"78.\">\n<p class=\"c-article-references__text\" id=\"ref-CR78\">Kraus, W. E. et al. 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. Lancet Diabetes Endocrinol. <b>7<\/b>, 673\u2013683 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S2213-8587(19)30151-2\" data-track-item_id=\"10.1016\/S2213-8587(19)30151-2\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS2213-8587%2819%2930151-2\" aria-label=\"Article reference 78\" data-doi=\"10.1016\/S2213-8587(19)30151-2\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31303390\" aria-label=\"PubMed reference 78\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6707879\" aria-label=\"PubMed Central reference 78\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 78\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=2%20years%20of%20calorie%20restriction%20and%20cardiometabolic%20risk%20%28CALERIE%29%3A%20exploratory%20outcomes%20of%20a%20multicentre%2C%20phase%202%2C%20randomised%20controlled%20trial&amp;journal=Lancet%20Diabetes%20Endocrinol.&amp;doi=10.1016%2FS2213-8587%2819%2930151-2&amp;volume=7&amp;pages=673-683&amp;publication_year=2019&amp;author=Kraus%2CWE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"79.\">\n<p class=\"c-article-references__text\" id=\"ref-CR79\">Huang, T. H. &amp; Ables, G. P. Dietary restrictions, bone density, and bone quality. Ann. N. Y. Acad. Sci. <b>1363<\/b>, 26\u201339 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/nyas.13004\" data-track-item_id=\"10.1111\/nyas.13004\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fnyas.13004\" aria-label=\"Article reference 79\" data-doi=\"10.1111\/nyas.13004\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XktFGmsLY%3D\" aria-label=\"CAS reference 79\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26881697\" aria-label=\"PubMed reference 79\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 79\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dietary%20restrictions%2C%20bone%20density%2C%20and%20bone%20quality&amp;journal=Ann.%20N.%20Y.%20Acad.%20Sci.&amp;doi=10.1111%2Fnyas.13004&amp;volume=1363&amp;pages=26-39&amp;publication_year=2016&amp;author=Huang%2CTH&amp;author=Ables%2CGP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"80.\">\n<p class=\"c-article-references__text\" id=\"ref-CR80\">Devlin, M. J. et al. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J. Bone Min. Res. <b>25<\/b>, 2078\u20132088 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/jbmr.82\" data-track-item_id=\"10.1002\/jbmr.82\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fjbmr.82\" aria-label=\"Article reference 80\" data-doi=\"10.1002\/jbmr.82\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 80\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20leads%20to%20high%20marrow%20adiposity%20and%20low%20bone%20mass%20in%20growing%20mice&amp;journal=J.%20Bone%20Min.%20Res.&amp;doi=10.1002%2Fjbmr.82&amp;volume=25&amp;pages=2078-2088&amp;publication_year=2010&amp;author=Devlin%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"81.\">\n<p class=\"c-article-references__text\" id=\"ref-CR81\">Bartell, S. M. et al. Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob\/ob mice. J. Bone Min. Res. <b>26<\/b>, 1710\u20131720 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/jbmr.406\" data-track-item_id=\"10.1002\/jbmr.406\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fjbmr.406\" aria-label=\"Article reference 81\" data-doi=\"10.1002\/jbmr.406\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhtVejtL7L\" aria-label=\"CAS reference 81\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 81\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20%28ICV%29%20leptin%20injection%20increases%20bone%20formation%2C%20bone%20mineral%20density%2C%20muscle%20mass%2C%20serum%20IGF-1%2C%20and%20the%20expression%20of%20osteogenic%20genes%20in%20leptin-deficient%20ob%2Fob%20mice&amp;journal=J.%20Bone%20Min.%20Res.&amp;doi=10.1002%2Fjbmr.406&amp;volume=26&amp;pages=1710-1720&amp;publication_year=2011&amp;author=Bartell%2CSM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"82.\">\n<p class=\"c-article-references__text\" id=\"ref-CR82\">Reid, I. R., Baldock, P. A. &amp; Cornish, J. Effects of leptin on the skeleton. Endocr. Rev. <b>39<\/b>, 938\u2013959 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1210\/er.2017-00226\" data-track-item_id=\"10.1210\/er.2017-00226\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1210%2Fer.2017-00226\" aria-label=\"Article reference 82\" data-doi=\"10.1210\/er.2017-00226\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30184053\" aria-label=\"PubMed reference 82\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 82\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20leptin%20on%20the%20skeleton&amp;journal=Endocr.%20Rev.&amp;doi=10.1210%2Fer.2017-00226&amp;volume=39&amp;pages=938-959&amp;publication_year=2018&amp;author=Reid%2CIR&amp;author=Baldock%2CPA&amp;author=Cornish%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"83.\">\n<p class=\"c-article-references__text\" id=\"ref-CR83\">Turner, R. T. et al. Peripheral leptin regulates bone formation. J. Bone Min. Res. <b>28<\/b>, 22\u201334 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/jbmr.1734\" data-track-item_id=\"10.1002\/jbmr.1734\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fjbmr.1734\" aria-label=\"Article reference 83\" data-doi=\"10.1002\/jbmr.1734\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhvVynurjI\" aria-label=\"CAS reference 83\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 83\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Peripheral%20leptin%20regulates%20bone%20formation&amp;journal=J.%20Bone%20Min.%20Res.&amp;doi=10.1002%2Fjbmr.1734&amp;volume=28&amp;pages=22-34&amp;publication_year=2013&amp;author=Turner%2CRT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"84.\">\n<p class=\"c-article-references__text\" id=\"ref-CR84\">Baek, K., Barlow, A. A., Allen, M. R. &amp; Bloomfield, S. A. Food restriction and simulated microgravity: effects on bone and serum leptin. J. Appl. Physiol. <b>104<\/b>, 1086\u20131093 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1152\/japplphysiol.01209.2007\" data-track-item_id=\"10.1152\/japplphysiol.01209.2007\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1152%2Fjapplphysiol.01209.2007\" aria-label=\"Article reference 84\" data-doi=\"10.1152\/japplphysiol.01209.2007\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXlsVensbg%3D\" aria-label=\"CAS reference 84\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18276897\" aria-label=\"PubMed reference 84\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 84\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Food%20restriction%20and%20simulated%20microgravity%3A%20effects%20on%20bone%20and%20serum%20leptin&amp;journal=J.%20Appl.%20Physiol.&amp;doi=10.1152%2Fjapplphysiol.01209.2007&amp;volume=104&amp;pages=1086-1093&amp;publication_year=2008&amp;author=Baek%2CK&amp;author=Barlow%2CAA&amp;author=Allen%2CMR&amp;author=Bloomfield%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"85.\">\n<p class=\"c-article-references__text\" id=\"ref-CR85\">Mitchell, S. E. et al. The effects of graded levels of calorie restriction: I. Impact of short term calorie and protein restriction on body composition in the C57BL\/6 mouse. Oncotarget <b>6<\/b>, 15902\u201315930 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.18632\/oncotarget.4142\" data-track-item_id=\"10.18632\/oncotarget.4142\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.18632%2Foncotarget.4142\" aria-label=\"Article reference 85\" data-doi=\"10.18632\/oncotarget.4142\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26079539\" aria-label=\"PubMed reference 85\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4599246\" aria-label=\"PubMed Central reference 85\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 85\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effects%20of%20graded%20levels%20of%20calorie%20restriction%3A%20I.%20Impact%20of%20short%20term%20calorie%20and%20protein%20restriction%20on%20body%20composition%20in%20the%20C57BL%2F6%20mouse&amp;journal=Oncotarget&amp;doi=10.18632%2Foncotarget.4142&amp;volume=6&amp;pages=15902-15930&amp;publication_year=2015&amp;author=Mitchell%2CSE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"86.\">\n<p class=\"c-article-references__text\" id=\"ref-CR86\">Banu, J., Orhii, P. B., Okafor, M. C., Wang, L. &amp; Kalu, D. N. Analysis of the effects of growth hormone, exercise and food restriction on cancellous bone in different bone sites in middle-aged female rats. Mech. Ageing Dev. <b>122<\/b>, 849\u2013864 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0047-6374(01)00243-3\" data-track-item_id=\"10.1016\/S0047-6374(01)00243-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0047-6374%2801%2900243-3\" aria-label=\"Article reference 86\" data-doi=\"10.1016\/S0047-6374(01)00243-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXjtFGjtbY%3D\" aria-label=\"CAS reference 86\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11337013\" aria-label=\"PubMed reference 86\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 86\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Analysis%20of%20the%20effects%20of%20growth%20hormone%2C%20exercise%20and%20food%20restriction%20on%20cancellous%20bone%20in%20different%20bone%20sites%20in%20middle-aged%20female%20rats&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2FS0047-6374%2801%2900243-3&amp;volume=122&amp;pages=849-864&amp;publication_year=2001&amp;author=Banu%2CJ&amp;author=Orhii%2CPB&amp;author=Okafor%2CMC&amp;author=Wang%2CL&amp;author=Kalu%2CDN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"87.\">\n<p class=\"c-article-references__text\" id=\"ref-CR87\">Maier, G. W. &amp; Kreis, M. E. Limited nutritional energy supply differentially impairs growth and bone mineralization of the developing lumbar vertebrae in minipigs. Bone <b>36<\/b>, 512\u2013520 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.bone.2004.11.003\" data-track-item_id=\"10.1016\/j.bone.2004.11.003\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.bone.2004.11.003\" aria-label=\"Article reference 87\" data-doi=\"10.1016\/j.bone.2004.11.003\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15777652\" aria-label=\"PubMed reference 87\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 87\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Limited%20nutritional%20energy%20supply%20differentially%20impairs%20growth%20and%20bone%20mineralization%20of%20the%20developing%20lumbar%20vertebrae%20in%20minipigs&amp;journal=Bone&amp;doi=10.1016%2Fj.bone.2004.11.003&amp;volume=36&amp;pages=512-520&amp;publication_year=2005&amp;author=Maier%2CGW&amp;author=Kreis%2CME\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"88.\">\n<p class=\"c-article-references__text\" id=\"ref-CR88\">Soltani, S., Hunter, G. R., Kazemi, A. &amp; Shab-Bidar, S. The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials. Osteoporos. Int. <b>27<\/b>, 2655\u20132671 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s00198-016-3617-4\" data-track-item_id=\"10.1007\/s00198-016-3617-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00198-016-3617-4\" aria-label=\"Article reference 88\" data-doi=\"10.1007\/s00198-016-3617-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XnsVeqsb4%3D\" aria-label=\"CAS reference 88\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27154437\" aria-label=\"PubMed reference 88\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 88\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effects%20of%20weight%20loss%20approaches%20on%20bone%20mineral%20density%20in%20adults%3A%20a%20systematic%20review%20and%20meta-analysis%20of%20randomized%20controlled%20trials&amp;journal=Osteoporos.%20Int.&amp;doi=10.1007%2Fs00198-016-3617-4&amp;volume=27&amp;pages=2655-2671&amp;publication_year=2016&amp;author=Soltani%2CS&amp;author=Hunter%2CGR&amp;author=Kazemi%2CA&amp;author=Shab-Bidar%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"89.\">\n<p class=\"c-article-references__text\" id=\"ref-CR89\">Veronese, N. &amp; Reginster, J. Y. The effects of calorie restriction, intermittent fasting and vegetarian diets on bone health. Aging Clin. Exp. Res. <b>31<\/b>, 753\u2013758 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s40520-019-01174-x\" data-track-item_id=\"10.1007\/s40520-019-01174-x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s40520-019-01174-x\" aria-label=\"Article reference 89\" data-doi=\"10.1007\/s40520-019-01174-x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30903600\" aria-label=\"PubMed reference 89\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 89\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20effects%20of%20calorie%20restriction%2C%20intermittent%20fasting%20and%20vegetarian%20diets%20on%20bone%20health&amp;journal=Aging%20Clin.%20Exp.%20Res.&amp;doi=10.1007%2Fs40520-019-01174-x&amp;volume=31&amp;pages=753-758&amp;publication_year=2019&amp;author=Veronese%2CN&amp;author=Reginster%2CJY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"90.\">\n<p class=\"c-article-references__text\" id=\"ref-CR90\">Villareal, D. T. et al. Effect of two-year caloric restriction on bone metabolism and bone mineral density in non-obese younger adults: a randomized clinical trial. J. Bone Min. Res. <b>31<\/b>, 40\u201351 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/jbmr.2701\" data-track-item_id=\"10.1002\/jbmr.2701\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fjbmr.2701\" aria-label=\"Article reference 90\" data-doi=\"10.1002\/jbmr.2701\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XksFelug%3D%3D\" aria-label=\"CAS reference 90\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 90\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20two-year%20caloric%20restriction%20on%20bone%20metabolism%20and%20bone%20mineral%20density%20in%20non-obese%20younger%20adults%3A%20a%20randomized%20clinical%20trial&amp;journal=J.%20Bone%20Min.%20Res.&amp;doi=10.1002%2Fjbmr.2701&amp;volume=31&amp;pages=40-51&amp;publication_year=2016&amp;author=Villareal%2CDT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"91.\">\n<p class=\"c-article-references__text\" id=\"ref-CR91\">Villareal, D. T. et al. Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch. Intern. Med. <b>166<\/b>, 2502\u20132510 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/archinte.166.22.2502\" data-track-item_id=\"10.1001\/archinte.166.22.2502\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Farchinte.166.22.2502\" aria-label=\"Article reference 91\" data-doi=\"10.1001\/archinte.166.22.2502\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17159017\" aria-label=\"PubMed reference 91\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 91\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bone%20mineral%20density%20response%20to%20caloric%20restriction-induced%20weight%20loss%20or%20exercise-induced%20weight%20loss%3A%20a%20randomized%20controlled%20trial&amp;journal=Arch.%20Intern.%20Med.&amp;doi=10.1001%2Farchinte.166.22.2502&amp;volume=166&amp;pages=2502-2510&amp;publication_year=2006&amp;author=Villareal%2CDT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"92.\">\n<p class=\"c-article-references__text\" id=\"ref-CR92\">Villareal, D. T. et al. Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition. Aging Cell <b>10<\/b>, 96\u2013102 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1474-9726.2010.00643.x\" data-track-item_id=\"10.1111\/j.1474-9726.2010.00643.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1474-9726.2010.00643.x\" aria-label=\"Article reference 92\" data-doi=\"10.1111\/j.1474-9726.2010.00643.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhvFSnsrk%3D\" aria-label=\"CAS reference 92\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20969721\" aria-label=\"PubMed reference 92\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 92\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reduced%20bone%20mineral%20density%20is%20not%20associated%20with%20significantly%20reduced%20bone%20quality%20in%20men%20and%20women%20practicing%20long-term%20calorie%20restriction%20with%20adequate%20nutrition&amp;journal=Aging%20Cell&amp;doi=10.1111%2Fj.1474-9726.2010.00643.x&amp;volume=10&amp;pages=96-102&amp;publication_year=2011&amp;author=Villareal%2CDT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"93.\">\n<p class=\"c-article-references__text\" id=\"ref-CR93\">Colman, R. J., Beasley, T. M., Allison, D. B. &amp; Weindruch, R. Skeletal effects of long-term caloric restriction in rhesus monkeys. Age <b>34<\/b>, 1133\u20131143 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1007\/s11357-011-9354-x\" data-track-item_id=\"10.1007\/s11357-011-9354-x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s11357-011-9354-x\" aria-label=\"Article reference 93\" data-doi=\"10.1007\/s11357-011-9354-x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhsVWntLnJ\" aria-label=\"CAS reference 93\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22189911\" aria-label=\"PubMed reference 93\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 93\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Skeletal%20effects%20of%20long-term%20caloric%20restriction%20in%20rhesus%20monkeys&amp;journal=Age&amp;doi=10.1007%2Fs11357-011-9354-x&amp;volume=34&amp;pages=1133-1143&amp;publication_year=2012&amp;author=Colman%2CRJ&amp;author=Beasley%2CTM&amp;author=Allison%2CDB&amp;author=Weindruch%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"94.\">\n<p class=\"c-article-references__text\" id=\"ref-CR94\">Hawkins, J., Cifuentes, M., Pleshko, N. L., Ambia-Sobhan, H. &amp; Shapses, S. A. Energy restriction is associated with lower bone mineral density of the tibia and femur in lean but not obese female rats. J. Nutr. <b>140<\/b>, 31\u201337 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3945\/jn.109.111450\" data-track-item_id=\"10.3945\/jn.109.111450\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3945%2Fjn.109.111450\" aria-label=\"Article reference 94\" data-doi=\"10.3945\/jn.109.111450\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXltFSlsr0%3D\" aria-label=\"CAS reference 94\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19923391\" aria-label=\"PubMed reference 94\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2793120\" aria-label=\"PubMed Central reference 94\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 94\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Energy%20restriction%20is%20associated%20with%20lower%20bone%20mineral%20density%20of%20the%20tibia%20and%20femur%20in%20lean%20but%20not%20obese%20female%20rats&amp;journal=J.%20Nutr.&amp;doi=10.3945%2Fjn.109.111450&amp;volume=140&amp;pages=31-37&amp;publication_year=2010&amp;author=Hawkins%2CJ&amp;author=Cifuentes%2CM&amp;author=Pleshko%2CNL&amp;author=Ambia-Sobhan%2CH&amp;author=Shapses%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"95.\">\n<p class=\"c-article-references__text\" id=\"ref-CR95\">Kalu, D. N. et al. Lifelong food restriction prevents senile osteopenia and hyperparathyroidism in F344 rats. Mech. Ageing Dev. <b>26<\/b>, 103\u2013112 (1984).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/0047-6374(84)90169-6\" data-track-item_id=\"10.1016\/0047-6374(84)90169-6\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2F0047-6374%2884%2990169-6\" aria-label=\"Article reference 95\" data-doi=\"10.1016\/0047-6374(84)90169-6\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaL2cXlsFSmsr4%3D\" aria-label=\"CAS reference 95\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=6748753\" aria-label=\"PubMed reference 95\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 95\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Lifelong%20food%20restriction%20prevents%20senile%20osteopenia%20and%20hyperparathyroidism%20in%20F344%20rats&amp;journal=Mech.%20Ageing%20Dev.&amp;doi=10.1016%2F0047-6374%2884%2990169-6&amp;volume=26&amp;pages=103-112&amp;publication_year=1984&amp;author=Kalu%2CDN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"96.\">\n<p class=\"c-article-references__text\" id=\"ref-CR96\">Westerbeek, Z. W., Hepple, R. T. &amp; Zernicke, R. F. Effects of aging and caloric restriction on bone structure and mechanical properties. J. Gerontol. A Biol. Sci. Med. Sci. <b>63<\/b>, 1131\u20131136 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/63.11.1131\" data-track-item_id=\"10.1093\/gerona\/63.11.1131\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2F63.11.1131\" aria-label=\"Article reference 96\" data-doi=\"10.1093\/gerona\/63.11.1131\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19038827\" aria-label=\"PubMed reference 96\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 96\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20aging%20and%20caloric%20restriction%20on%20bone%20structure%20and%20mechanical%20properties&amp;journal=J.%20Gerontol.%20A%20Biol.%20Sci.%20Med.%20Sci.&amp;doi=10.1093%2Fgerona%2F63.11.1131&amp;volume=63&amp;pages=1131-1136&amp;publication_year=2008&amp;author=Westerbeek%2CZW&amp;author=Hepple%2CRT&amp;author=Zernicke%2CRF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"97.\">\n<p class=\"c-article-references__text\" id=\"ref-CR97\">Pifferi, F. et al. Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. Commun. Biol. <b>1<\/b>, 30 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s42003-018-0024-8\" data-track-item_id=\"10.1038\/s42003-018-0024-8\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs42003-018-0024-8\" aria-label=\"Article reference 97\" data-doi=\"10.1038\/s42003-018-0024-8\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30271916\" aria-label=\"PubMed reference 97\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6123706\" aria-label=\"PubMed Central reference 97\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 97\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20increases%20lifespan%20but%20affects%20brain%20integrity%20in%20grey%20mouse%20lemur%20primates&amp;journal=Commun.%20Biol.&amp;doi=10.1038%2Fs42003-018-0024-8&amp;volume=1&amp;publication_year=2018&amp;author=Pifferi%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"98.\">\n<p class=\"c-article-references__text\" id=\"ref-CR98\">Lupien, S. J. et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat. Neurosci. <b>1<\/b>, 69\u201373 (1998).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/271\" data-track-item_id=\"10.1038\/271\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2F271\" aria-label=\"Article reference 98\" data-doi=\"10.1038\/271\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXitVCnt7c%3D\" aria-label=\"CAS reference 98\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10195112\" aria-label=\"PubMed reference 98\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 98\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cortisol%20levels%20during%20human%20aging%20predict%20hippocampal%20atrophy%20and%20memory%20deficits&amp;journal=Nat.%20Neurosci.&amp;doi=10.1038%2F271&amp;volume=1&amp;pages=69-73&amp;publication_year=1998&amp;author=Lupien%2CSJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"99.\">\n<p class=\"c-article-references__text\" id=\"ref-CR99\">Patel, N. V. &amp; Finch, C. E. The glucocorticoid paradox of caloric restriction in slowing brain aging. Neurobiol. Aging <b>23<\/b>, 707\u2013717 (2002).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0197-4580(02)00017-9\" data-track-item_id=\"10.1016\/S0197-4580(02)00017-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0197-4580%2802%2900017-9\" aria-label=\"Article reference 99\" data-doi=\"10.1016\/S0197-4580(02)00017-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XotVCitbo%3D\" aria-label=\"CAS reference 99\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12392776\" aria-label=\"PubMed reference 99\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 99\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20glucocorticoid%20paradox%20of%20caloric%20restriction%20in%20slowing%20brain%20aging&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2FS0197-4580%2802%2900017-9&amp;volume=23&amp;pages=707-717&amp;publication_year=2002&amp;author=Patel%2CNV&amp;author=Finch%2CCE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"100.\">\n<p class=\"c-article-references__text\" id=\"ref-CR100\">Ramos-Cabrer, P. et al. Reversible reduction in brain myelin content upon marathon running. Nat. Metab. <a href=\"https:\/\/doi.org\/10.1038\/s42255-025-01244-7\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s42255-025-01244-7\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s42255-025-01244-7<\/a> (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s42255-025-01244-7\" data-track-item_id=\"10.1038\/s42255-025-01244-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs42255-025-01244-7\" aria-label=\"Article reference 100\" data-doi=\"10.1038\/s42255-025-01244-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40128612\" aria-label=\"PubMed reference 100\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 100\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reversible%20reduction%20in%20brain%20myelin%20content%20upon%20marathon%20running.&amp;journal=Nat.%20Metab.&amp;doi=10.1038%2Fs42255-025-01244-7&amp;publication_year=2025&amp;author=Ramos-Cabrer%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"101.\">\n<p class=\"c-article-references__text\" id=\"ref-CR101\">Hedden, T. &amp; Gabrieli, J. D. Insights into the ageing mind: a view from cognitive neuroscience. Nat. Rev. Neurosci. <b>5<\/b>, 87\u201396 (2004).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nrn1323\" data-track-item_id=\"10.1038\/nrn1323\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnrn1323\" aria-label=\"Article reference 101\" data-doi=\"10.1038\/nrn1323\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXks1Crtg%3D%3D\" aria-label=\"CAS reference 101\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=14735112\" aria-label=\"PubMed reference 101\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 101\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Insights%20into%20the%20ageing%20mind%3A%20a%20view%20from%20cognitive%20neuroscience&amp;journal=Nat.%20Rev.%20Neurosci.&amp;doi=10.1038%2Fnrn1323&amp;volume=5&amp;pages=87-96&amp;publication_year=2004&amp;author=Hedden%2CT&amp;author=Gabrieli%2CJD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"102.\">\n<p class=\"c-article-references__text\" id=\"ref-CR102\">Picq, J. L., Aujard, F., Volk, A. &amp; Dhenain, M. Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments. Neurobiol. Aging <b>33<\/b>, 1096\u20131109 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.neurobiolaging.2010.09.009\" data-track-item_id=\"10.1016\/j.neurobiolaging.2010.09.009\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.neurobiolaging.2010.09.009\" aria-label=\"Article reference 102\" data-doi=\"10.1016\/j.neurobiolaging.2010.09.009\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20970891\" aria-label=\"PubMed reference 102\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 102\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Age-related%20cerebral%20atrophy%20in%20nonhuman%20primates%20predicts%20cognitive%20impairments&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2Fj.neurobiolaging.2010.09.009&amp;volume=33&amp;pages=1096-1109&amp;publication_year=2012&amp;author=Picq%2CJL&amp;author=Aujard%2CF&amp;author=Volk%2CA&amp;author=Dhenain%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"103.\">\n<p class=\"c-article-references__text\" id=\"ref-CR103\">Bond, N. W., Everitt, A. V. &amp; Walton, J. Effects of dietary restriction on radial-arm maze performance and flavor memory in aged rats. Neurobiol. Aging <b>10<\/b>, 27\u201330 (1989).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0197-4580(89)80007-7\" data-track-item_id=\"10.1016\/S0197-4580(89)80007-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0197-4580%2889%2980007-7\" aria-label=\"Article reference 103\" data-doi=\"10.1016\/S0197-4580(89)80007-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaL1MzjtVKqtw%3D%3D\" aria-label=\"CAS reference 103\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2755555\" aria-label=\"PubMed reference 103\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 103\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20dietary%20restriction%20on%20radial-arm%20maze%20performance%20and%20flavor%20memory%20in%20aged%20rats&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2FS0197-4580%2889%2980007-7&amp;volume=10&amp;pages=27-30&amp;publication_year=1989&amp;author=Bond%2CNW&amp;author=Everitt%2CAV&amp;author=Walton%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"104.\">\n<p class=\"c-article-references__text\" id=\"ref-CR104\">Martin, B., Mattson, M. P. &amp; Maudsley, S. Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res. Rev. <b>5<\/b>, 332\u2013353 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.arr.2006.04.002\" data-track-item_id=\"10.1016\/j.arr.2006.04.002\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.arr.2006.04.002\" aria-label=\"Article reference 104\" data-doi=\"10.1016\/j.arr.2006.04.002\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XhtFKqtL%2FL\" aria-label=\"CAS reference 104\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16899414\" aria-label=\"PubMed reference 104\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2622429\" aria-label=\"PubMed Central reference 104\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 104\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20and%20intermittent%20fasting%3A%20two%20potential%20diets%20for%20successful%20brain%20aging&amp;journal=Ageing%20Res.%20Rev.&amp;doi=10.1016%2Fj.arr.2006.04.002&amp;volume=5&amp;pages=332-353&amp;publication_year=2006&amp;author=Martin%2CB&amp;author=Mattson%2CMP&amp;author=Maudsley%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"105.\">\n<p class=\"c-article-references__text\" id=\"ref-CR105\">Bellush, L. L., Wright, A. M., Walker, J. P., Kopchick, J. &amp; Colvin, R. A. Caloric restriction and spatial learning in old mice. Physiol. Behav. <b>60<\/b>, 541\u2013547 (1996).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0031-9384(96)80029-1\" data-track-item_id=\"10.1016\/S0031-9384(96)80029-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0031-9384%2896%2980029-1\" aria-label=\"Article reference 105\" data-doi=\"10.1016\/S0031-9384(96)80029-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK28XkvFShsrY%3D\" aria-label=\"CAS reference 105\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8840916\" aria-label=\"PubMed reference 105\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 105\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20and%20spatial%20learning%20in%20old%20mice&amp;journal=Physiol.%20Behav.&amp;doi=10.1016%2FS0031-9384%2896%2980029-1&amp;volume=60&amp;pages=541-547&amp;publication_year=1996&amp;author=Bellush%2CLL&amp;author=Wright%2CAM&amp;author=Walker%2CJP&amp;author=Kopchick%2CJ&amp;author=Colvin%2CRA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"106.\">\n<p class=\"c-article-references__text\" id=\"ref-CR106\">Pitsikas, N., Carli, M., Fidecka, S. &amp; Algeri, S. Effect of life-long hypocaloric diet on age-related changes in motor and cognitive behavior in a rat population. Neurobiol. Aging <b>11<\/b>, 417\u2013423 (1990).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/0197-4580(90)90008-N\" data-track-item_id=\"10.1016\/0197-4580(90)90008-N\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2F0197-4580%2890%2990008-N\" aria-label=\"Article reference 106\" data-doi=\"10.1016\/0197-4580(90)90008-N\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK3czktVCgsQ%3D%3D\" aria-label=\"CAS reference 106\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2381501\" aria-label=\"PubMed reference 106\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 106\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20life-long%20hypocaloric%20diet%20on%20age-related%20changes%20in%20motor%20and%20cognitive%20behavior%20in%20a%20rat%20population&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2F0197-4580%2890%2990008-N&amp;volume=11&amp;pages=417-423&amp;publication_year=1990&amp;author=Pitsikas%2CN&amp;author=Carli%2CM&amp;author=Fidecka%2CS&amp;author=Algeri%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"107.\">\n<p class=\"c-article-references__text\" id=\"ref-CR107\">Markowska, A. L. &amp; Savonenko, A. Retardation of cognitive aging by life-long diet restriction: implications for genetic variance. Neurobiol. Aging <b>23<\/b>, 75\u201386 (2002).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0197-4580(01)00249-4\" data-track-item_id=\"10.1016\/S0197-4580(01)00249-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0197-4580%2801%2900249-4\" aria-label=\"Article reference 107\" data-doi=\"10.1016\/S0197-4580(01)00249-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11755022\" aria-label=\"PubMed reference 107\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 107\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Retardation%20of%20cognitive%20aging%20by%20life-long%20diet%20restriction%3A%20implications%20for%20genetic%20variance&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2FS0197-4580%2801%2900249-4&amp;volume=23&amp;pages=75-86&amp;publication_year=2002&amp;author=Markowska%2CAL&amp;author=Savonenko%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"108.\">\n<p class=\"c-article-references__text\" id=\"ref-CR108\">Markowska, A. L. Life-long diet restriction failed to retard cognitive aging in Fischer-344 rats. Neurobiol. Aging <b>20<\/b>, 177\u2013189 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0197-4580(99)00031-7\" data-track-item_id=\"10.1016\/S0197-4580(99)00031-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0197-4580%2899%2900031-7\" aria-label=\"Article reference 108\" data-doi=\"10.1016\/S0197-4580(99)00031-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BD3c%2FgsFCiuw%3D%3D\" aria-label=\"CAS reference 108\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10537027\" aria-label=\"PubMed reference 108\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 108\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Life-long%20diet%20restriction%20failed%20to%20retard%20cognitive%20aging%20in%20Fischer-344%20rats&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2FS0197-4580%2899%2900031-7&amp;volume=20&amp;pages=177-189&amp;publication_year=1999&amp;author=Markowska%2CAL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"109.\">\n<p class=\"c-article-references__text\" id=\"ref-CR109\">Sarker, M. R. et al. Curcumin mimics the neurocognitive and anti-inflammatory effects of caloric restriction in a mouse model of midlife obesity. PLoS One <b>10<\/b>, e0140431 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pone.0140431\" data-track-item_id=\"10.1371\/journal.pone.0140431\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pone.0140431\" aria-label=\"Article reference 109\" data-doi=\"10.1371\/journal.pone.0140431\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26473740\" aria-label=\"PubMed reference 109\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4608712\" aria-label=\"PubMed Central reference 109\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 109\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Curcumin%20mimics%20the%20neurocognitive%20and%20anti-inflammatory%20effects%20of%20caloric%20restriction%20in%20a%20mouse%20model%20of%20midlife%20obesity&amp;journal=PLoS%20One&amp;doi=10.1371%2Fjournal.pone.0140431&amp;volume=10&amp;publication_year=2015&amp;author=Sarker%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"110.\">\n<p class=\"c-article-references__text\" id=\"ref-CR110\">Yanai, S., Okaichi, Y. &amp; Okaichi, H. Long-term dietary restriction causes negative effects on cognitive functions in rats. Neurobiol. Aging <b>25<\/b>, 325\u2013332 (2004).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0197-4580(03)00115-5\" data-track-item_id=\"10.1016\/S0197-4580(03)00115-5\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0197-4580%2803%2900115-5\" aria-label=\"Article reference 110\" data-doi=\"10.1016\/S0197-4580(03)00115-5\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15123338\" aria-label=\"PubMed reference 110\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 110\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Long-term%20dietary%20restriction%20causes%20negative%20effects%20on%20cognitive%20functions%20in%20rats&amp;journal=Neurobiol.%20Aging&amp;doi=10.1016%2FS0197-4580%2803%2900115-5&amp;volume=25&amp;pages=325-332&amp;publication_year=2004&amp;author=Yanai%2CS&amp;author=Okaichi%2CY&amp;author=Okaichi%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"111.\">\n<p class=\"c-article-references__text\" id=\"ref-CR111\">Padamsey, Z., Katsanevaki, D., Dupuy, N. &amp; Rochefort, N. L. Neocortex saves energy by reducing coding precision during food scarcity. Neuron <b>110<\/b>, 280\u2013296 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.neuron.2021.10.024\" data-track-item_id=\"10.1016\/j.neuron.2021.10.024\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.neuron.2021.10.024\" aria-label=\"Article reference 111\" data-doi=\"10.1016\/j.neuron.2021.10.024\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXisVamurzK\" aria-label=\"CAS reference 111\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34741806\" aria-label=\"PubMed reference 111\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8788933\" aria-label=\"PubMed Central reference 111\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 111\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neocortex%20saves%20energy%20by%20reducing%20coding%20precision%20during%20food%20scarcity&amp;journal=Neuron&amp;doi=10.1016%2Fj.neuron.2021.10.024&amp;volume=110&amp;pages=280-296&amp;publication_year=2022&amp;author=Padamsey%2CZ&amp;author=Katsanevaki%2CD&amp;author=Dupuy%2CN&amp;author=Rochefort%2CNL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"112.\">\n<p class=\"c-article-references__text\" id=\"ref-CR112\">Morgan, J. F. Eating disorders and reproduction. Aust. N. Z. J. Obstet. Gynaecol. <b>39<\/b>, 167\u2013173 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1479-828X.1999.tb03364.x\" data-track-item_id=\"10.1111\/j.1479-828X.1999.tb03364.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1479-828X.1999.tb03364.x\" aria-label=\"Article reference 112\" data-doi=\"10.1111\/j.1479-828X.1999.tb03364.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BD3c3hs1Gktw%3D%3D\" aria-label=\"CAS reference 112\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10755771\" aria-label=\"PubMed reference 112\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 112\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Eating%20disorders%20and%20reproduction&amp;journal=Aust.%20N.%20Z.%20J.%20Obstet.%20Gynaecol.&amp;doi=10.1111%2Fj.1479-828X.1999.tb03364.x&amp;volume=39&amp;pages=167-173&amp;publication_year=1999&amp;author=Morgan%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"113.\">\n<p class=\"c-article-references__text\" id=\"ref-CR113\">Morgan, J. F., Lacey, J. H. &amp; Reid, F. Anorexia nervosa: changes in sexuality during weight restoration. Psychosom. Med. <b>61<\/b>, 541\u2013545 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1097\/00006842-199907000-00019\" data-track-item_id=\"10.1097\/00006842-199907000-00019\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1097%2F00006842-199907000-00019\" aria-label=\"Article reference 113\" data-doi=\"10.1097\/00006842-199907000-00019\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK1MzntFelsQ%3D%3D\" aria-label=\"CAS reference 113\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10443763\" aria-label=\"PubMed reference 113\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 113\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anorexia%20nervosa%3A%20changes%20in%20sexuality%20during%20weight%20restoration&amp;journal=Psychosom.%20Med.&amp;doi=10.1097%2F00006842-199907000-00019&amp;volume=61&amp;pages=541-545&amp;publication_year=1999&amp;author=Morgan%2CJF&amp;author=Lacey%2CJH&amp;author=Reid%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"114.\">\n<p class=\"c-article-references__text\" id=\"ref-CR114\">Johnston, S. L. et al. Having it all: historical energy intakes do not generate the anticipated trade-offs in fecundity. Proc. Biol. Sci. <b>273<\/b>, 1369\u20131374 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BD28zmsVKisw%3D%3D\" aria-label=\"CAS reference 114\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16777725\" aria-label=\"PubMed reference 114\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1560301\" aria-label=\"PubMed Central reference 114\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 114\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Having%20it%20all%3A%20historical%20energy%20intakes%20do%20not%20generate%20the%20anticipated%20trade-offs%20in%20fecundity&amp;journal=Proc.%20Biol.%20Sci.&amp;volume=273&amp;pages=1369-1374&amp;publication_year=2006&amp;author=Johnston%2CSL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"115.\">\n<p class=\"c-article-references__text\" id=\"ref-CR115\">Selesniemi, K., Lee, H. J. &amp; Tilly, J. L. Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age. Aging Cell <b>7<\/b>, 622\u2013629 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1474-9726.2008.00409.x\" data-track-item_id=\"10.1111\/j.1474-9726.2008.00409.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1474-9726.2008.00409.x\" aria-label=\"Article reference 115\" data-doi=\"10.1111\/j.1474-9726.2008.00409.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXht1ClsLfO\" aria-label=\"CAS reference 115\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18549458\" aria-label=\"PubMed reference 115\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 115\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Moderate%20caloric%20restriction%20initiated%20in%20rodents%20during%20adulthood%20sustains%20function%20of%20the%20female%20reproductive%20axis%20into%20advanced%20chronological%20age&amp;journal=Aging%20Cell&amp;doi=10.1111%2Fj.1474-9726.2008.00409.x&amp;volume=7&amp;pages=622-629&amp;publication_year=2008&amp;author=Selesniemi%2CK&amp;author=Lee%2CHJ&amp;author=Tilly%2CJL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"116.\">\n<p class=\"c-article-references__text\" id=\"ref-CR116\">Isola, J. V. V. et al. Mild calorie restriction, but not 17\u03b1-estradiol, extends ovarian reserve and fertility in female mice. Exp. Gerontol. <b>159<\/b>, 111669 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.exger.2021.111669\" data-track-item_id=\"10.1016\/j.exger.2021.111669\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.exger.2021.111669\" aria-label=\"Article reference 116\" data-doi=\"10.1016\/j.exger.2021.111669\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhtFWnt7jK\" aria-label=\"CAS reference 116\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35032571\" aria-label=\"PubMed reference 116\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8920046\" aria-label=\"PubMed Central reference 116\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 116\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mild%20calorie%20restriction%2C%20but%20not%2017%CE%B1-estradiol%2C%20extends%20ovarian%20reserve%20and%20fertility%20in%20female%20mice&amp;journal=Exp.%20Gerontol.&amp;doi=10.1016%2Fj.exger.2021.111669&amp;volume=159&amp;publication_year=2022&amp;author=Isola%2CJVV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"117.\">\n<p class=\"c-article-references__text\" id=\"ref-CR117\">Mossa, F. et al. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biol. Reprod. <b>88<\/b>, 92 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1095\/biolreprod.112.107235\" data-track-item_id=\"10.1095\/biolreprod.112.107235\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1095%2Fbiolreprod.112.107235\" aria-label=\"Article reference 117\" data-doi=\"10.1095\/biolreprod.112.107235\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23426432\" aria-label=\"PubMed reference 117\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 117\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Maternal%20undernutrition%20in%20cows%20impairs%20ovarian%20and%20cardiovascular%20systems%20in%20their%20offspring&amp;journal=Biol.%20Reprod.&amp;doi=10.1095%2Fbiolreprod.112.107235&amp;volume=88&amp;publication_year=2013&amp;author=Mossa%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"118.\">\n<p class=\"c-article-references__text\" id=\"ref-CR118\">Harrath, A. H., Alrezaki, A., Mansour, L., Alwasel, S. H. &amp; Palomba, S. Food restriction during pregnancy and female offspring fertility: adverse effects of reprogrammed reproductive lifespan. J. Ovarian Res. <b>10<\/b>, 77 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener\" data-track-label=\"10.1186\/s13048-017-0372-x\" data-track-item_id=\"10.1186\/s13048-017-0372-x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s13048-017-0372-x\" aria-label=\"Article reference 118\" data-doi=\"10.1186\/s13048-017-0372-x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29282125\" aria-label=\"PubMed reference 118\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5745764\" aria-label=\"PubMed Central reference 118\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 118\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Food%20restriction%20during%20pregnancy%20and%20female%20offspring%20fertility%3A%20adverse%20effects%20of%20reprogrammed%20reproductive%20lifespan&amp;journal=J.%20Ovarian%20Res.&amp;doi=10.1186%2Fs13048-017-0372-x&amp;volume=10&amp;publication_year=2017&amp;author=Harrath%2CAH&amp;author=Alrezaki%2CA&amp;author=Mansour%2CL&amp;author=Alwasel%2CSH&amp;author=Palomba%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"119.\">\n<p class=\"c-article-references__text\" id=\"ref-CR119\">Zanini, B. M. et al. Calorie restriction during gestation affects ovarian reserve in offspring in the mouse. Reprod. Fertil. Dev. <b>32<\/b>, 1338\u20131349 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1071\/RD20107\" data-track-item_id=\"10.1071\/RD20107\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1071%2FRD20107\" aria-label=\"Article reference 119\" data-doi=\"10.1071\/RD20107\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXis1Wls7bF\" aria-label=\"CAS reference 119\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33243369\" aria-label=\"PubMed reference 119\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 119\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20during%20gestation%20affects%20ovarian%20reserve%20in%20offspring%20in%20the%20mouse&amp;journal=Reprod.%20Fertil.%20Dev.&amp;doi=10.1071%2FRD20107&amp;volume=32&amp;pages=1338-1349&amp;publication_year=2020&amp;author=Zanini%2CBM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"120.\">\n<p class=\"c-article-references__text\" id=\"ref-CR120\">Martin, C. K. et al. Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: the CALERIE 2 randomized clinical trial. JAMA Intern. Med. <b>176<\/b>, 743\u2013752 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jamainternmed.2016.1189\" data-track-item_id=\"10.1001\/jamainternmed.2016.1189\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjamainternmed.2016.1189\" aria-label=\"Article reference 120\" data-doi=\"10.1001\/jamainternmed.2016.1189\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27136347\" aria-label=\"PubMed reference 120\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4905696\" aria-label=\"PubMed Central reference 120\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 120\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20calorie%20restriction%20on%20mood%2C%20quality%20of%20life%2C%20sleep%2C%20and%20sexual%20function%20in%20healthy%20nonobese%20adults%3A%20the%20CALERIE%202%20randomized%20clinical%20trial&amp;journal=JAMA%20Intern.%20Med.&amp;doi=10.1001%2Fjamainternmed.2016.1189&amp;volume=176&amp;pages=743-752&amp;publication_year=2016&amp;author=Martin%2CCK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"121.\">\n<p class=\"c-article-references__text\" id=\"ref-CR121\">Effros, R. B., Walford, R. L., Weindruch, R. &amp; Mitcheltree, C. Influences of dietary restriction on immunity to influenza in aged mice. J. Gerontol. <b>46<\/b>, B142\u2013B147 (1991).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/geronj\/46.4.B142\" data-track-item_id=\"10.1093\/geronj\/46.4.B142\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgeronj%2F46.4.B142\" aria-label=\"Article reference 121\" data-doi=\"10.1093\/geronj\/46.4.B142\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK3Mzgt1Ojtw%3D%3D\" aria-label=\"CAS reference 121\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=2071828\" aria-label=\"PubMed reference 121\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 121\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Influences%20of%20dietary%20restriction%20on%20immunity%20to%20influenza%20in%20aged%20mice&amp;journal=J.%20Gerontol.&amp;doi=10.1093%2Fgeronj%2F46.4.B142&amp;volume=46&amp;pages=B142-B147&amp;publication_year=1991&amp;author=Effros%2CRB&amp;author=Walford%2CRL&amp;author=Weindruch%2CR&amp;author=Mitcheltree%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"122.\">\n<p class=\"c-article-references__text\" id=\"ref-CR122\">Peck, M. D., Babcock, G. F. &amp; Alexander, J. W. The role of protein and calorie restriction in outcome from Salmonella infection in mice. J. Parenter. Enter. Nutr. <b>16<\/b>, 561\u2013565 (1992).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1177\/0148607192016006561\" data-track-item_id=\"10.1177\/0148607192016006561\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1177%2F0148607192016006561\" aria-label=\"Article reference 122\" data-doi=\"10.1177\/0148607192016006561\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK3s7ls1Wnug%3D%3D\" aria-label=\"CAS reference 122\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 122\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20protein%20and%20calorie%20restriction%20in%20outcome%20from%20Salmonella%20infection%20in%20mice&amp;journal=J.%20Parenter.%20Enter.%20Nutr.&amp;doi=10.1177%2F0148607192016006561&amp;volume=16&amp;pages=561-565&amp;publication_year=1992&amp;author=Peck%2CMD&amp;author=Babcock%2CGF&amp;author=Alexander%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"123.\">\n<p class=\"c-article-references__text\" id=\"ref-CR123\">Hasegawa, A. et al. Alternate day calorie restriction improves systemic inflammation in a mouse model of sepsis induced by cecal ligation and puncture. J. Surg. Res. <b>174<\/b>, 136\u2013141 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jss.2010.11.883\" data-track-item_id=\"10.1016\/j.jss.2010.11.883\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jss.2010.11.883\" aria-label=\"Article reference 123\" data-doi=\"10.1016\/j.jss.2010.11.883\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xks1Wisr0%3D\" aria-label=\"CAS reference 123\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21195419\" aria-label=\"PubMed reference 123\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 123\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Alternate%20day%20calorie%20restriction%20improves%20systemic%20inflammation%20in%20a%20mouse%20model%20of%20sepsis%20induced%20by%20cecal%20ligation%20and%20puncture&amp;journal=J.%20Surg.%20Res.&amp;doi=10.1016%2Fj.jss.2010.11.883&amp;volume=174&amp;pages=136-141&amp;publication_year=2012&amp;author=Hasegawa%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"124.\">\n<p class=\"c-article-references__text\" id=\"ref-CR124\">MacDonald, L., Radler, M., Paolini, A. G. &amp; Kent, S. Calorie restriction attenuates LPS-induced sickness behavior and shifts hypothalamic signaling pathways to an anti-inflammatory bias. Am. J. Physiol. Regul. Integr. Comp. Physiol. <b>301<\/b>, R172\u2013R184 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1152\/ajpregu.00057.2011\" data-track-item_id=\"10.1152\/ajpregu.00057.2011\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1152%2Fajpregu.00057.2011\" aria-label=\"Article reference 124\" data-doi=\"10.1152\/ajpregu.00057.2011\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXptlSgu7k%3D\" aria-label=\"CAS reference 124\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21525175\" aria-label=\"PubMed reference 124\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 124\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Calorie%20restriction%20attenuates%20LPS-induced%20sickness%20behavior%20and%20shifts%20hypothalamic%20signaling%20pathways%20to%20an%20anti-inflammatory%20bias&amp;journal=Am.%20J.%20Physiol.%20Regul.%20Integr.%20Comp.%20Physiol.&amp;doi=10.1152%2Fajpregu.00057.2011&amp;volume=301&amp;pages=R172-R184&amp;publication_year=2011&amp;author=MacDonald%2CL&amp;author=Radler%2CM&amp;author=Paolini%2CAG&amp;author=Kent%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"125.\">\n<p class=\"c-article-references__text\" id=\"ref-CR125\">Spadaro, O. et al. Caloric restriction in humans reveals immunometabolic regulators of health span. Science <b>375<\/b>, 671\u2013677 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1126\/science.abg7292\" data-track-item_id=\"10.1126\/science.abg7292\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1126%2Fscience.abg7292\" aria-label=\"Article reference 125\" data-doi=\"10.1126\/science.abg7292\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XjvFKktr8%3D\" aria-label=\"CAS reference 125\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35143297\" aria-label=\"PubMed reference 125\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10061495\" aria-label=\"PubMed Central reference 125\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 125\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20in%20humans%20reveals%20immunometabolic%20regulators%20of%20health%20span&amp;journal=Science&amp;doi=10.1126%2Fscience.abg7292&amp;volume=375&amp;pages=671-677&amp;publication_year=2022&amp;author=Spadaro%2CO\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"126.\">\n<p class=\"c-article-references__text\" id=\"ref-CR126\">Ritz, B. W., Aktan, I., Nogusa, S. &amp; Gardner, E. M. Energy restriction impairs natural killer cell function and increases the severity of influenza infection in young adult male C57BL\/6 mice. J. Nutr. <b>138<\/b>, 2269\u20132275 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3945\/jn.108.093633\" data-track-item_id=\"10.3945\/jn.108.093633\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3945%2Fjn.108.093633\" aria-label=\"Article reference 126\" data-doi=\"10.3945\/jn.108.093633\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXht1ymtr%2FP\" aria-label=\"CAS reference 126\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18936230\" aria-label=\"PubMed reference 126\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2635521\" aria-label=\"PubMed Central reference 126\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 126\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Energy%20restriction%20impairs%20natural%20killer%20cell%20function%20and%20increases%20the%20severity%20of%20influenza%20infection%20in%20young%20adult%20male%20C57BL%2F6%20mice&amp;journal=J.%20Nutr.&amp;doi=10.3945%2Fjn.108.093633&amp;volume=138&amp;pages=2269-2275&amp;publication_year=2008&amp;author=Ritz%2CBW&amp;author=Aktan%2CI&amp;author=Nogusa%2CS&amp;author=Gardner%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"127.\">\n<p class=\"c-article-references__text\" id=\"ref-CR127\">Gardner, E. M., Beli, E., Clinthorne, J. F. &amp; Duriancik, D. M. Energy intake and response to infection with influenza. Annu. Rev. Nutr. <b>31<\/b>, 353\u2013367 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1146\/annurev-nutr-081810-160812\" data-track-item_id=\"10.1146\/annurev-nutr-081810-160812\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1146%2Fannurev-nutr-081810-160812\" aria-label=\"Article reference 127\" data-doi=\"10.1146\/annurev-nutr-081810-160812\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhtFais7rN\" aria-label=\"CAS reference 127\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21548773\" aria-label=\"PubMed reference 127\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 127\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Energy%20intake%20and%20response%20to%20infection%20with%20influenza&amp;journal=Annu.%20Rev.%20Nutr.&amp;doi=10.1146%2Fannurev-nutr-081810-160812&amp;volume=31&amp;pages=353-367&amp;publication_year=2011&amp;author=Gardner%2CEM&amp;author=Beli%2CE&amp;author=Clinthorne%2CJF&amp;author=Duriancik%2CDM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"128.\">\n<p class=\"c-article-references__text\" id=\"ref-CR128\">Clinthorne, J. F., Beli, E., Duriancik, D. M. &amp; Gardner, E. M. NK cell maturation and function in C57BL\/6 mice are altered by caloric restriction. J. Immunol. <b>190<\/b>, 712\u2013722 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.4049\/jimmunol.1201837\" data-track-item_id=\"10.4049\/jimmunol.1201837\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.4049%2Fjimmunol.1201837\" aria-label=\"Article reference 128\" data-doi=\"10.4049\/jimmunol.1201837\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXjtlGrsw%3D%3D\" aria-label=\"CAS reference 128\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23241894\" aria-label=\"PubMed reference 128\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 128\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=NK%20cell%20maturation%20and%20function%20in%20C57BL%2F6%20mice%20are%20altered%20by%20caloric%20restriction&amp;journal=J.%20Immunol.&amp;doi=10.4049%2Fjimmunol.1201837&amp;volume=190&amp;pages=712-722&amp;publication_year=2013&amp;author=Clinthorne%2CJF&amp;author=Beli%2CE&amp;author=Duriancik%2CDM&amp;author=Gardner%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"129.\">\n<p class=\"c-article-references__text\" id=\"ref-CR129\">Gardner, E. M. Caloric restriction decreases survival of aged mice in response to primary influenza infection. J. Gerontol. A Biol. Sci. Med. Sci. <b>60<\/b>, 688\u2013694 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/60.6.688\" data-track-item_id=\"10.1093\/gerona\/60.6.688\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2F60.6.688\" aria-label=\"Article reference 129\" data-doi=\"10.1093\/gerona\/60.6.688\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15983169\" aria-label=\"PubMed reference 129\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 129\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20decreases%20survival%20of%20aged%20mice%20in%20response%20to%20primary%20influenza%20infection&amp;journal=J.%20Gerontol.%20A%20Biol.%20Sci.%20Med.%20Sci.&amp;doi=10.1093%2Fgerona%2F60.6.688&amp;volume=60&amp;pages=688-694&amp;publication_year=2005&amp;author=Gardner%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"130.\">\n<p class=\"c-article-references__text\" id=\"ref-CR130\">Ikeda, S. et al. Dietary restriction impairs neutrophil exudation by reducing CD11b\/CD18 expression and chemokine production. Arch. Surg. <b>136<\/b>, 297\u2013304 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/archsurg.136.3.297\" data-track-item_id=\"10.1001\/archsurg.136.3.297\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Farchsurg.136.3.297\" aria-label=\"Article reference 130\" data-doi=\"10.1001\/archsurg.136.3.297\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXitF2is7k%3D\" aria-label=\"CAS reference 130\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11231849\" aria-label=\"PubMed reference 130\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 130\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dietary%20restriction%20impairs%20neutrophil%20exudation%20by%20reducing%20CD11b%2FCD18%20expression%20and%20chemokine%20production&amp;journal=Arch.%20Surg.&amp;doi=10.1001%2Farchsurg.136.3.297&amp;volume=136&amp;pages=297-304&amp;publication_year=2001&amp;author=Ikeda%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"131.\">\n<p class=\"c-article-references__text\" id=\"ref-CR131\">Clinthorne, J. F., Adams, D. J., Fenton, J. I., Ritz, B. W. &amp; Gardner, E. M. Short-term re-feeding of previously energy-restricted C57BL\/6 male mice restores body weight and body fat and attenuates the decline in natural killer cell function after primary influenza infection. J. Nutr. <b>140<\/b>, 1495\u20131501 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3945\/jn.110.122408\" data-track-item_id=\"10.3945\/jn.110.122408\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3945%2Fjn.110.122408\" aria-label=\"Article reference 131\" data-doi=\"10.3945\/jn.110.122408\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXpslyju7g%3D\" aria-label=\"CAS reference 131\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20534876\" aria-label=\"PubMed reference 131\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2903303\" aria-label=\"PubMed Central reference 131\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 131\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Short-term%20re-feeding%20of%20previously%20energy-restricted%20C57BL%2F6%20male%20mice%20restores%20body%20weight%20and%20body%20fat%20and%20attenuates%20the%20decline%20in%20natural%20killer%20cell%20function%20after%20primary%20influenza%20infection&amp;journal=J.%20Nutr.&amp;doi=10.3945%2Fjn.110.122408&amp;volume=140&amp;pages=1495-1501&amp;publication_year=2010&amp;author=Clinthorne%2CJF&amp;author=Adams%2CDJ&amp;author=Fenton%2CJI&amp;author=Ritz%2CBW&amp;author=Gardner%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"132.\">\n<p class=\"c-article-references__text\" id=\"ref-CR132\">Shi, H. N., Scott, M. E., Stevenson, M. M. &amp; Koski, K. G. Energy restriction and zinc deficiency impair the functions of murine T cells and antigen-presenting cells during gastrointestinal nematode infection. J. Nutr. <b>128<\/b>, 20\u201327 (1998).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jn\/128.1.20\" data-track-item_id=\"10.1093\/jn\/128.1.20\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjn%2F128.1.20\" aria-label=\"Article reference 132\" data-doi=\"10.1093\/jn\/128.1.20\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1cXnt1Ghtw%3D%3D\" aria-label=\"CAS reference 132\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9430597\" aria-label=\"PubMed reference 132\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 132\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Energy%20restriction%20and%20zinc%20deficiency%20impair%20the%20functions%20of%20murine%20T%20cells%20and%20antigen-presenting%20cells%20during%20gastrointestinal%20nematode%20infection&amp;journal=J.%20Nutr.&amp;doi=10.1093%2Fjn%2F128.1.20&amp;volume=128&amp;pages=20-27&amp;publication_year=1998&amp;author=Shi%2CHN&amp;author=Scott%2CME&amp;author=Stevenson%2CMM&amp;author=Koski%2CKG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"133.\">\n<p class=\"c-article-references__text\" id=\"ref-CR133\">Sun, D., Muthukumar, A. R., Lawrence, R. A. &amp; Fernandes, G. Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL\/6 mice. Clin. Diagn. Lab. Immunol. <b>8<\/b>, 1003\u20131011 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/CDLI.8.5.1003-1011.2001\" data-track-item_id=\"10.1128\/CDLI.8.5.1003-1011.2001\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FCDLI.8.5.1003-1011.2001\" aria-label=\"Article reference 133\" data-doi=\"10.1128\/CDLI.8.5.1003-1011.2001\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DC%2BD3MvosFGhuw%3D%3D\" aria-label=\"CAS reference 133\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11527818\" aria-label=\"PubMed reference 133\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC96186\" aria-label=\"PubMed Central reference 133\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 133\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20calorie%20restriction%20on%20polymicrobial%20peritonitis%20induced%20by%20cecum%20ligation%20and%20puncture%20in%20young%20C57BL%2F6%20mice&amp;journal=Clin.%20Diagn.%20Lab.%20Immunol.&amp;doi=10.1128%2FCDLI.8.5.1003-1011.2001&amp;volume=8&amp;pages=1003-1011&amp;publication_year=2001&amp;author=Sun%2CD&amp;author=Muthukumar%2CAR&amp;author=Lawrence%2CRA&amp;author=Fernandes%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"134.\">\n<p class=\"c-article-references__text\" id=\"ref-CR134\">Kristan, D. M. Chronic calorie restriction increases susceptibility of laboratory mice (Mus musculus) to a primary intestinal parasite infection. Aging Cell <b>6<\/b>, 817\u2013825 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1474-9726.2007.00345.x\" data-track-item_id=\"10.1111\/j.1474-9726.2007.00345.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1474-9726.2007.00345.x\" aria-label=\"Article reference 134\" data-doi=\"10.1111\/j.1474-9726.2007.00345.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXhsVeksbfF\" aria-label=\"CAS reference 134\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17973970\" aria-label=\"PubMed reference 134\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 134\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chronic%20calorie%20restriction%20increases%20susceptibility%20of%20laboratory%20mice%20%28Mus%20musculus%29%20to%20a%20primary%20intestinal%20parasite%20infection&amp;journal=Aging%20Cell&amp;doi=10.1111%2Fj.1474-9726.2007.00345.x&amp;volume=6&amp;pages=817-825&amp;publication_year=2007&amp;author=Kristan%2CDM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"Osborne, T. B., Mendel, L. B. &amp; Ferry, E. L. The effect of retardation of growth upon the&hellip;\n","protected":false},"author":2,"featured_media":34801,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4318],"tags":[6442,20179,3968,105,20180,20181,4434,2753,16,15],"class_list":{"0":"post-34800","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nutrition","8":"tag-endocrinology","9":"tag-feeding-behaviour","10":"tag-general","11":"tag-health","12":"tag-homeostasis","13":"tag-medicine-public-health","14":"tag-nutrition","15":"tag-risk-factors","16":"tag-uk","17":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114368667246589634","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/34800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=34800"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/34800\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/34801"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=34800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=34800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=34800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}