{"id":390210,"date":"2025-09-01T21:23:12","date_gmt":"2025-09-01T21:23:12","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/390210\/"},"modified":"2025-09-01T21:23:12","modified_gmt":"2025-09-01T21:23:12","slug":"recruitment-starts-on-first-genetic-screening-for-brain-aneurysm","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/390210\/","title":{"rendered":"Recruitment starts on first genetic screening for brain aneurysm"},"content":{"rendered":"<p>\t\t<a href=\"https:\/\/www.labnews.co.uk\/files\/assets\/image\/2192194\/@Maxim Berg brain jpg OL.jpg\" class=\"zoom zoom--right\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.europesays.com\/uk\/wp-content\/uploads\/2025\/09\/480_405@Maxim_Berg_brain_jpg_OL.jpg\" class=\"rightx article-imagex\" alt=\"\"\/><\/a><\/p>\n<p>Genetic screening is being employed to improve early treatment and detection of brain aneurysms.<\/p>\n<p>The ROAR (Risk Of Aneurysm Rupture) <a href=\"https:\/\/roarstudy.co.uk\/roar-study\" target=\"_blank\" rel=\"noopener\">Study<\/a>, already tracking 20,000 NHS patients, is claimed to be the largest project of its sort in the world.<\/p>\n<p>Under its umbrella, a new multicentre research project based in Southampton is now embarking on the first study of the genetic markers that suggest a person\u2019s predisposition to the condition.<\/p>\n<p>The ROAR-DNA Project involves researchers from University Hospital Southampton NHS Foundation Trust (UHS) and the University of Southampton examining data from 6,000 patients over a four year period.<\/p>\n<p>The hope is to develop a more refined system to predict rupture potential, extending the list of risk factors to include gender and family history. Recruitment for the project begins this autumn.<\/p>\n<p>Professor Diederik Bulters, UHS consultant neurosurgeon, honorary professor of neurovascular surgery at the University of Southampton Diederik Bulters is ROAR Study chief investigator.<\/p>\n<p>Explaining the project\u2019s potential impact, he said:\u00a0<\/p>\n<p>&#8220;Most brain aneurysms will never rupture but we currently have no way of identifying the minority that will\u2026ROAR-DNA is designed to fill the critical gap in our understanding of genetic risk.<\/p>\n<p>\u201cIt could pave the way for targeted NHS screening programmes that identify and monitor high-risk individuals before an aneurysm becomes life-threatening\u2014and open up new possibilities for therapeutic treatment to reduce the need for invasive surgery.&#8221;<\/p>\n<p>Of 2 million people in the UK with evidence of aneurysms, an estimated 3,000 to 5,000 people experience a brain aneurysm rupture each year, with around half proving fatal.<\/p>\n<p>While the majority are rated as one-off incidents caused by swellings in the brain\u2019s blood vessels, around one in six patients with the condition have a parent or sibling\u00a0 who is also affected.<\/p>\n<p>The Southampton study will compare data from sufferers with others lacking aneurysms \u2013 a project made possible, said Bulters, by access to the NHS\u2019s \u201cunique\u201d infrastructure and secure patient data, together with support from the Medical Research Council.<\/p>\n<p>Pic: Maxim Berg<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"Genetic screening is being employed to improve early treatment and detection of brain aneurysms. The ROAR (Risk Of&hellip;\n","protected":false},"author":2,"featured_media":390211,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[267,70,16,15],"class_list":{"0":"post-390210","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-uk","11":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/115131148551330902","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/390210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=390210"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/390210\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/390211"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=390210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=390210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=390210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}