{"id":393916,"date":"2025-09-03T06:50:26","date_gmt":"2025-09-03T06:50:26","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/393916\/"},"modified":"2025-09-03T06:50:26","modified_gmt":"2025-09-03T06:50:26","slug":"its-not-only-genes-gene-diet-interactions-also-regulate-circadian-rhythms","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/393916\/","title":{"rendered":"It’s not only genes, gene-diet interactions also regulate circadian rhythms"},"content":{"rendered":"

\t\"ADiet interacts with an individual\u2019s genetic makeup, influencing daily patterns of gene activity in the liver.<\/strong><\/p>\n

Our bodies follow a natural 24-hour cycle known as the\u00a0circadian rhythm that influences everything from sleep to metabolism. While scientists have long known that certain core circadian clock genes help regulate these rhythms, a new study led by researchers at Baylor College of Medicine reveals that there is an additional layer of regulation \u2013 diet interacts with an individual\u2019s genetic makeup, influencing daily patterns of gene activity in the liver, especially those related to fat metabolism.<\/p>\n

Diet and genes work together<\/strong>
\n\"\"<\/a>Dr. Dongyin Guan<\/strong><\/p>\n

\u201cOur study, published in Cell Metabolism<\/a>, provides a new perspective to the question, \u2018Why do some people gain weight more easily or develop liver problems while others don\u2019t, even when they eat similar diets?\u2019\u201d said corresponding author Dr.\u00a0 Dongyin Guan<\/a>, assistant professor of medicine \u2013 endocrinology<\/a> and molecular and cellular biology<\/a> at Baylor. Guan also is a member of Baylor\u2019s Dan L Duncan Comprehensive Cancer Center<\/a>.<\/p>\n

\"\"<\/a>Dr. Ying Chen<\/strong><\/p>\n

\u201cWe found that individual genetic differences affect the timing of gene activity in the liver in response to food,\u201d said co-first author Dr. Ying Chen<\/a>, postdoctoral fellow in the Guan lab<\/a>. \u201cGenes and diet work together to shape the liver\u2019s daily rhythm, which in turn can affect how fats are processed and stored.\u201d<\/p>\n

The researchers studied both\u00a0human liver samples\u00a0and\u00a0two strains of mice\u00a0with different genetic backgrounds. They looked at how genes in the liver turn on and off throughout the day and how this changes when the mice are fed a high-fat diet.<\/p>\n

To explore the underlying molecular mechanisms of this collaboration between diet and genetics, the team also examined 3D interactions between DNA regions. They investigated how \u2018enhancers,\u2019 which are genes that boost gene activity, connect with \u2018promoters,\u2019 which start gene activity, in a time-dependent manner.<\/p>\n

Guan and his colleagues found that genetic variation contributes to daily gene activity patterns in both humans and mice. In humans, thousands of genes showed rhythmic activity only in people with specific gene variants.<\/p>\n

\"\"<\/a>Dishu Zhou<\/strong><\/p>\n

\u201cWe also found that diet changes the rhythm of gene expression in mouse liver, but differently for different genes,\u201d said co-first author Dishu Zhou<\/a>, research assistant in the Guan lab. \u201cWhen mice were fed a high-fat diet, their liver gene activity changed, but not in the same way for all genes. Some genes kept their rhythm, some lost it, and others gained it.\u201d<\/p>\n

Remarkably, genetics and nutrition work together to control more than 80% of the rhythmic enhancer-promoter interactions. \u201cWe identified gene ESRR\u03b3 as a noncanonical clock regulator, meaning that it is not part of the core circadian clock gene family but still plays a significant role in regulating daily rhythms,\u201d Guan said. \u201cMice lacking ESRR\u03b3 lost many of these rhythmic connections in the liver and showed disrupted fat metabolism.\u201d<\/p>\n

The findings support the possibility of personalized chronotherapy<\/strong><\/p>\n

The findings show that fat metabolism is time-sensitive and gene-dependent. In mice with different genetic backgrounds, the size of fat droplets in the liver changed throughout the day, but only in those with active ESRR\u03b3. This suggests that\u00a0individual genetic makeup could influence not just how the body handles fat, but when it does so.<\/p>\n

\"\"<\/a>Graphical abstract of the work. Image courtesy of the authors\/Cell Metabolism, 2025.<\/a><\/p>\n

This study focused on liver and fat metabolism, but the authors propose that the same principles may apply to other organs and diseases. The findings not only provide an improved understanding of daily metabolic changes but also support the possibility of personalized chronotherapy \u2013 tailoring mealtimes or scheduling medication or other treatments based on a person\u2019s genetic profile to optimize health outcomes.<\/p>\n

The study collaborators include Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S. Julie-Ann Lloyd, Cam Mong La, Inna I. Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A. An, Zheng Sun, Mark A. Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D. Rabinowitz, Samer G. Mattar and Yongyou Zhang. The authors are affiliated with Baylor College of Medicine, Xiamen University, University of Pennsylvania, Case Western Reserve University School of Medicine, University of California, Irvine School of Medicine, University of Texas Health Science Center at Houston or Princeton University.<\/p>\n

This study was supported by American Liver Foundation Postdoctoral Research Fellowship Award NIH K01-DK125602, CPRIT Scholar in Cancer Research (RR210029), V Foundation (V2022-026), pilot award NIH R37CA296577, DK056338, P30-CA125123, TRISH NNX16AO69A, H-NORC, R01AG069966, R01ES034768, NIH R01DK111495, U54HL165442 and U01HL166058 and an SVRF grant from Additional Ventures. Further support was provided by NIH\/NCI R00 CA237618 and R01-AA029124, USDA\/ARS grant 58-3092-5-001 and CPRIT Scholar Award (PR210056), Pew Foundation and the Fundamental Research Funds for the Central Universities of China-Xiamen University (20720180048).<\/p>\n

\u00a0<\/p>\n

By Ana Mar\u00eda Rodr\u00edguez, Ph.D<\/a><\/strong>.<\/p>\n

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