{"id":457948,"date":"2025-09-28T13:15:11","date_gmt":"2025-09-28T13:15:11","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/457948\/"},"modified":"2025-09-28T13:15:11","modified_gmt":"2025-09-28T13:15:11","slug":"largest-study-of-its-kind-reveals-the-genes-behind-dyslexia-sciencealert","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/457948\/","title":{"rendered":"Largest Study of Its Kind Reveals The Genes Behind Dyslexia : ScienceAlert"},"content":{"rendered":"<p>A massive study involving genetic data from over 1.2 million people has identified over a dozen new gene regions associated with dyslexia.<\/p>\n<p>&#8220;We have produced the largest genetic study of dyslexia to date,&#8221; <a href=\"https:\/\/doi.org\/10.1038\/s41398-025-03514-0\" target=\"_blank\" rel=\"noopener\">write<\/a> the study authors, led by University of Edinburgh molecular geneticist Hayley Mountford.<\/p>\n<p>Dyslexia is a neurodevelopmental brain difference that can make certain aspects of modern life challenging. In the current study, participants had challenges reading and\/or writing, although that is not the case in all people with dyslexia; some find other aspects of verbal processing more challenging than their peers, such as spelling and grammar, or following verbal instructions.<\/p>\n<p><strong>Related: <a href=\"https:\/\/www.sciencealert.com\/several-psychiatric-disorders-share-the-same-root-cause-study-reveals\" target=\"_blank\" rel=\"noopener\"><strong>S<\/strong>everal Psychiatric Disorders Share The Same Root Cause, Study Reveals<\/a><\/strong><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.europesays.com\/uk\/wp-content\/uploads\/2025\/09\/ChildHoldingBookOpen-e1758584257151.jpg\" alt=\"child holding book open\" width=\"642\" height=\"427\" class=\"wp-image-175099 size-full\" loading=\"lazy\"\/>(<a href=\"https:\/\/unsplash.com\/photos\/person-wearing-blue-long-sleeved-shirt-reading-book-g3O4mCifZEk\" target=\"_blank\" rel=\"noopener\">Josh Applegate\/Unsplash<\/a>)<\/p>\n<p>As with the other neurodivergences, like  <a href=\"https:\/\/www.sciencealert.com\/autism-spectrum-disorder\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73013\" data-postid=\"175089\" rel=\"nofollow noopener\" target=\"_self\">autism<\/a> or  <a href=\"https:\/\/www.sciencealert.com\/what-is-adhd\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73112\" data-postid=\"175089\" rel=\"nofollow noopener\" target=\"_self\">ADHD<\/a>, dyslexia comes with <a href=\"https:\/\/www.sciencealert.com\/having-dyslexia-could-mean-your-brain-is-wired-to-make-better-decisions\" target=\"_blank\" rel=\"noopener\">advantages as well<\/a>, such as <a href=\"https:\/\/doi.org\/10.1016\/j.ridd.2021.104036\" target=\"_blank\" rel=\"noopener\">higher non-verbal creativity<\/a>.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.3390\/brainsci12010027\" target=\"_blank\" rel=\"noopener\">Past twin studies<\/a> have suggested that genes strongly determine dyslexia, so Mountford and colleagues took up the challenge of pinpointing what those genetic associations are.<\/p>\n<p>Their genome-wide study identified 80 regions associated with dyslexia, including 36 regions not previously reported as significant. Thirteen of these regions were novel to science, with no prior link to dyslexia.<\/p>\n<p>Many of the newly associated genes are involved in early brain development. And, as expected, some of them are <a href=\"https:\/\/doi.org\/10.1177\/09567976241293999\" target=\"_blank\" rel=\"noopener\">shared with ADHD<\/a>, which can often occur alongside dyslexia.<\/p>\n<p>In the vast datasets, the researchers also found correlations between dyslexia and measures of <a href=\"https:\/\/www.sciencealert.com\/large-body-map-study-suggests-chronic-pain-comes-in-9-distinct-types\" target=\"_blank\" rel=\"noopener\">chronic pain<\/a>.<\/p>\n<p>&#8220;The underlying mechanism remains unelucidated, however, the genetic overlap between pain-related phenotypes and neurodevelopmental traits may hint at a shared biological basis,&#8221; Mountford and team <a href=\"https:\/\/doi.org\/10.1038\/s41398-025-03514-0\" target=\"_blank\" rel=\"noopener\">write<\/a> in their paper.<\/p>\n<p>With these newly identified gene associations, researchers might finally start unraveling these connections.<\/p>\n<p>This research was published in <a href=\"https:\/\/doi.org\/10.1038\/s41398-025-03514-0\" target=\"_blank\" rel=\"noopener\">Translational Psychiatry<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"A massive study involving genetic data from over 1.2 million people has identified over a dozen new gene&hellip;\n","protected":false},"author":2,"featured_media":457949,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[267,120,70,16,15],"class_list":{"0":"post-457948","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-msft-content","10":"tag-science","11":"tag-uk","12":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/115282111650047529","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/457948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=457948"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/457948\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/457949"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=457948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=457948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=457948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}