{"id":49194,"date":"2025-04-25T11:00:07","date_gmt":"2025-04-25T11:00:07","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/49194\/"},"modified":"2025-04-25T11:00:07","modified_gmt":"2025-04-25T11:00:07","slug":"hudsonalpha-launches-pilot-study-to-examine-how-genetics-and-lifestyle-impact-alzheimers-risk","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/49194\/","title":{"rendered":"HudsonAlpha launches pilot study to examine how genetics and lifestyle impact Alzheimer\u2019s risk"},"content":{"rendered":"<p class=\"text | article-text\">HUNTSVILLE, Ala. (<a href=\"http:\/\/www.waff.com\/\" target=\"_blank\" rel=\"noopener\">WAFF<\/a>) &#8211; HudsonAlpha launched a pilot study to see how genetics and lifestyle influence a person\u2019s risk of developing Alzheimer\u2019s disease and related dementias.<\/p>\n<p class=\"text | article-text\">The pilot study called HOPE AD (Healthy Outcomes through Phenomic Explorations for Alzheimer\u2019s Disease) is enrolling participants at the Smith Family Clinic for Genomic Medicine in Huntsville.<\/p>\n<p class=\"text | article-text\">The study aims to enroll 200 healthy adults between the ages of 65 and 75 who have a close family member (parent, sibling, or child) with dementia but don\u2019t have cognitive impairment themselves.<\/p>\n<p class=\"text | article-text\">Officials say eligible participants will be invited to an initial visit at the Smith Family Clinic, where they will undergo routine medical exams, including cognitive testing and wellness assessments, and family history\/medical history overviews.<\/p>\n<p class=\"text | article-text\">All eligible participants will receive clinical results, including:<\/p>\n<ul class=\"list | article-list\">\n<li>APOE status- a well-known gene linked to Alzheimer\u2019s risk<\/li>\n<li>Polygenic risk score- an analysis that combines multiple genes to provide a more complete picture of disease risk<\/li>\n<li>pTau217 protein levels- a brain protein, or \u201cbiomarker,\u201d known to be elevated in early Alzheimer\u2019s disease<\/li>\n<\/ul>\n<p class=\"text | article-text\">\u201cAlzheimer\u2019s disease and other dementias begin years before any symptoms appear, so waiting until someone shows signs of memory decline may be too late,\u201d said Nick Cochran, PhD, HudsonAlpha Faculty Investigator and lead researcher at HudsonAlpha on the study. \u201cThis project is a chance to shift from reacting to preventing. We\u2019re exploring whether giving people personalized health information can empower them to make changes that protect brain health.\u201d<\/p>\n<p class=\"text | article-text\">Organizers said the study uses a \u201cphenomic\u201d approach, capturing highly detailed data about participants\u2019 health, environment, and lifestyle. They added that it helps researchers paint a fuller picture of dementia risk than genetics alone.<\/p>\n<p class=\"text | article-text\">Results from the pilot will inform a more extensive study in the coming years.<\/p>\n<p class=\"text | article-text\">To learn more about the Hope AD study and see if you\u2019re eligible, click here or contact the Smith Family Clinic at 256-327-9640.<\/p>\n<p class=\"text | article-text\"><a href=\"https:\/\/www.youtube.com\/@waff48news\" target=\"_self\" rel=\"noopener\">Click Here to Subscribe on YouTube:<\/a> Watch the latest WAFF 48 news, sports &amp; weather videos on our YouTube channel!<\/p>\n<p class=\"copyright |\">Copyright 2025 WAFF. All rights reserved.<\/p>\n","protected":false},"excerpt":{"rendered":"HUNTSVILLE, Ala. (WAFF) &#8211; HudsonAlpha launched a pilot study to see how genetics and lifestyle influence a person\u2019s&hellip;\n","protected":false},"author":2,"featured_media":49195,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[231,425,267,26618,26616,26612,26619,26436,26613,70,26617,16,15,26614,26615],"class_list":{"0":"post-49194","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-alzheimers-disease","9":"tag-dementia","10":"tag-genetics","11":"tag-hope-ad-study-by-hudson-alpha","12":"tag-hudson-alpha-study","13":"tag-hudsonalpha","14":"tag-hudsonalpha-in-huntsville","15":"tag-huntsville","16":"tag-nick-cochran","17":"tag-science","18":"tag-smith-family-for-genomic-medicine","19":"tag-uk","20":"tag-united-kingdom","21":"tag-waff","22":"tag-waff-48"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114398260305264921","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/49194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=49194"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/49194\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/49195"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=49194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=49194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=49194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}