{"id":494952,"date":"2025-10-13T01:37:10","date_gmt":"2025-10-13T01:37:10","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/494952\/"},"modified":"2025-10-13T01:37:10","modified_gmt":"2025-10-13T01:37:10","slug":"advanced-genetic-tests-could-predict-patients-at-risk-of-blood-cancer-relapse","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/494952\/","title":{"rendered":"Advanced genetic tests could predict patients at risk of blood cancer relapse"},"content":{"rendered":"<p>Your support helps us to tell the story<\/p>\n<p class=\"sc-1uza6dc-0 jEZjIj\">From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it&#8217;s investigating the financials of Elon Musk&#8217;s pro-Trump PAC or producing our latest documentary, &#8216;The A Word&#8217;, which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.<\/p>\n<p class=\"sc-1uza6dc-0 jEZjIj\">At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.<\/p>\n<p class=\"sc-1uza6dc-0 jEZjIj\">The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.<\/p>\n<p><strong class=\"sc-1uza6dc-1 gunhQQ\">Your support makes all the difference.<\/strong>Read more<\/p>\n<p>Offering a combination of genetic tests to people with a \u201cvery complex\u201d blood cancer could accurately predict if the disease is likely to come back within 18 months of treatment, a study has found.<\/p>\n<p>The method picks up \u201chidden risks\u201d that traditional tests may miss, and could potentially benefit thousands of people in the UK with multiple myeloma, researchers said.<\/p>\n<p>Multiple myeloma happens when the bone marrow makes abnormal white blood cells, known as plasma cells, causing symptoms such as bone pain, headaches and muscle weakness.<\/p>\n<p>It affects around 33,000 people in the UK, with about 6,300 new cases every year.<\/p>\n<p>The disease is considered incurable, and while there are treatments that puts the cancer into remission, many patients relapse, usually within 18 months.<\/p>\n<p>Researchers at the <a href=\"https:\/\/www.independent.co.uk\/topic\/institute-of-cancer-research\" target=\"_blank\" rel=\"noopener\">Institute of Cancer Research<\/a> (ICR) suggest offering traditional <a href=\"https:\/\/www.independent.co.uk\/topic\/dna\" target=\"_blank\" rel=\"noopener\">DNA<\/a> tests alongside new <a href=\"https:\/\/www.independent.co.uk\/topic\/rna\" target=\"_blank\" rel=\"noopener\">RNA<\/a> gene expression tests could detect patients who are at risk of early relapse.<\/p>\n<p>DNA profiling is currently being used in specialist cancer centres and clinical trials.<\/p>\n<p>It looks for genetic mutations in myeloma cells, which can determine how aggressive the disease is.<\/p>\n<p>Meanwhile, the newer gene expression tests check how active certain genes are in cancer cells by measuring RNA, a type of molecule that carries instructions from DNA to make proteins.<\/p>\n<p>Both tests are usually done using bone marrow samples.<\/p>\n<p>Martin Kaiser, a professor in molecular haematology at The Institute of Cancer Research, <a href=\"https:\/\/www.independent.co.uk\/topic\/london\" target=\"_blank\" rel=\"noopener\">London<\/a>, and consultant haematologist at The Royal Marsden NHS Foundation Trust, said: \u201cMultiple myeloma is a very complex disease.<\/p>\n<p>\u201cWhile current treatments can work very well for many patients, there are others who do not respond well and may relapse early.<\/p>\n<p>\u201cSome patients relapse early after treatment, even though they didn\u2019t show any known high-risk signs at diagnosis.\u201d<\/p>\n<p>The study, published in the journal Blood, looked at data from 135 patients who took part in the MyelomaXI clinical trial.<\/p>\n<p>All had the same treatment, along with detailed genetic testing.<\/p>\n<p>The patients were tracked for seven years, and cancer returned in 18.5% within 18 months of having a stem cell transplant.<\/p>\n<p>Researchers suggest combining the two genetic tests would have predicted 84% of these early relapses.<\/p>\n<p>Prof Kaiser added: \u201cOur findings show that RNA-based testing can uncover hidden risks in multiple myeloma that <a href=\"https:\/\/www.independent.co.uk\/topic\/dna-tests\" target=\"_blank\" rel=\"noopener\">DNA tests<\/a> alone miss.<\/p>\n<p>\u201cBy combining DNA profiling with RNA-based testing, we could change how we diagnose and treat the disease, allowing us to personalise care and intervene earlier for patients at greatest risk.\u201d<\/p>\n<p>Professor Kristian Helin, chief executive of The Institute of Cancer Research, London, estimates early relapse \u201caffects thousands\u201d of patients in the UK.<\/p>\n<p>\u201cThis exciting discovery marks a major advance in our ability to identify and treat high-risk multiple myeloma more effectively,\u201d he said.<\/p>\n<p>\u201cBy combining DNA and RNA testing, our researchers have created a far more accurate method of predicting early relapse in this disease, which affects thousands in the UK and many more globally.<\/p>\n<p>\u201cIt is a powerful example of how precision diagnostics can transform patient care.<\/p>\n<p>\u201cEarlier and more reliable identification of high-risk patients allows clinicians to tailor treatment plans from the outset, with the potential to improve both survival and quality of life.<\/p>\n<p>\u201cIt also enables more efficient use of healthcare resources, ensuring that the right patients receive the right treatments at the right time.\u201d<\/p>\n<p>Shelagh McKinlay, director of research and advocacy at blood cancer charity Myeloma UK, which helped fund the study, said: \u201cWe believe that advanced genetic testing has the power to be transformative in the treatment of myeloma.<\/p>\n<p>\u201cBy pinpointing which patients are most likely to relapse and stop responding to currently available drugs, we can improve the lives of thousands of people affected by this incurable cancer.<\/p>\n<p>\u201cIt is a critical factor in delivering a functional cure, a key pillar of the Myeloma UK research strategy. Professor Kaiser\u2019s research is a major step in bringing forward truly personalised treatment and care for people with myeloma, and we\u2019re immensely proud to be funding this work.\u201d<\/p>\n<p>From 2026, the Royal Marsden hospital in London will become the first in the UK to offer a gene expression profiling test to multiple myeloma patients.<\/p>\n<p>It is hoped it will allow medics to better understand how cancer cells are behaving before planning treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"Your support helps us to tell the story From reproductive rights to climate change to Big Tech, The&hellip;\n","protected":false},"author":2,"featured_media":494953,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[267,70,16,15],"class_list":{"0":"post-494952","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-uk","11":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/115364301979612872","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/494952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=494952"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/494952\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/494953"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=494952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=494952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=494952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}