{"id":53288,"date":"2025-04-26T23:13:11","date_gmt":"2025-04-26T23:13:11","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/53288\/"},"modified":"2025-04-26T23:13:11","modified_gmt":"2025-04-26T23:13:11","slug":"four-gene-combo-might-predict-lethality-of-stomach-cancer-health","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/53288\/","title":{"rendered":"Four-Gene Combo Might Predict Lethality Of Stomach Cancer | Health"},"content":{"rendered":"<p>                                <strong>Key Takeaways<\/strong><\/p>\n<ul>\n<li>\n<p>A four-gene set can predict how lethal a stomach cancer could be<\/p>\n<\/li>\n<li>\n<p>Patients with the gene combo were more likely to die from their cancer or have it return<\/p>\n<\/li>\n<li>\n<p>The combo included some genes already linked to cancer<\/p>\n<\/li>\n<\/ul>\n<p>FRIDAY, April 25, 2025 (HealthDay News) \u2014 Four specific genes serve as a telltale clue to how potentially deadly <a href=\"https:\/\/www.healthday.com\/a-to-z-health\/cancer\/gastrointestinal-cancer-2662248241.html\" target=\"_blank\" rel=\"noopener\">stomach cancers<\/a> will develop and progress, a new study says.<\/p>\n<p>Testing for these genetic mutations could enable doctors to offer targeted treatments and spare some patients from going through aggressive measures like surgery or <a href=\"https:\/\/www.healthday.com\/a-to-z-health\/cancer\/chemotherapy-and-side-effects-648006.html\" target=\"_blank\" rel=\"noopener\">chemotherapy<\/a>, researchers will argue at the upcoming medical conference in San Diego.<\/p>\n<p>&#8220;Not all stomach cancers are equal,\u201d lead researcher <a href=\"https:\/\/www.medicosbrasil.com\/profissional\/ulysses-ribeiro-junior\" target=\"_blank\" rel=\"noopener\">Dr. Ulysses Ribeiro<\/a>, a professor at the S\u00e3o Paulo State Cancer Institute in Brazil, said in a news release.<\/p>\n<p>\u201cToday, most gastric cancers are treated the same way \u2014 with surgery and chemotherapy \u2014 but we hope to identify key molecular differences so we can tailor treatment to the biology of each patient\u2019s tumor,\u201d Ribeiro said.<\/p>\n<p>For the study, researchers analyzed 21 genes in tumor samples taken from 87 patients who\u2019d undergone surgery and chemo for stomach cancer.<\/p>\n<p>The team then compared how mutations in these genes tracked with patients\u2019 survival.<\/p>\n<p>About one-third of patients had changes in a specific combination of four genes \u2014 BRCA2, CDH1, RHOA and TP53 \u2013 and those patients were more likely to die from their cancer or have it return, results show.<\/p>\n<p>That genetic combo contained well-established cancer drivers like BRCA2 mutations, which have been linked to <a href=\"https:\/\/www.healthday.com\/a-to-z-health\/cancer\/breast-cancer-what-it-is-symptoms-types-stages-treatments\" target=\"_blank\" rel=\"noopener\">breast<\/a> and <a href=\"https:\/\/www.healthday.com\/a-to-z-health\/cancer\/ovarian-cancer-symptoms-and-treatment-647321.html\" target=\"_blank\" rel=\"noopener\">ovarian cancer<\/a>, as well as previously unknown genetic variants, researchers said.<\/p>\n<p>Researchers are now working to match these findings to established lab tests that could make it easy and affordable to screen tumors for the identified high-risk genetic pattern.<\/p>\n<p>\u201cWe believe that these findings move us closer to more personalized treatment based on each tumor\u2019s biology,\u201d Ribeiro said.<\/p>\n<p>He is scheduled to present these findings at the Digestive Disease Week meeting on May 3. Findings presented at medical meetings are considered preliminary until published in a peer-reviewed journal.<\/p>\n<p><strong>More information<\/strong><\/p>\n<p>The American Cancer Society has more on <a href=\"https:\/\/www.cancer.org\/cancer\/types\/stomach-cancer\/about.html\" target=\"_blank\" rel=\"noopener\">stomach cancer<\/a>.<\/p>\n<p>SOURCE: American Gastroenterological Association, news release, April 25, 2025<\/p>\n<p><strong>What This Means For You<\/strong><\/p>\n<p>A genetic test could one day identify people who need more aggressive treatment for their stomach cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"Key Takeaways A four-gene set can predict how lethal a stomach cancer could be Patients with the gene&hellip;\n","protected":false},"author":2,"featured_media":53289,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3846],"tags":[1204,17505,267,70,16,15],"class_list":{"0":"post-53288","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-cancer","9":"tag-consumer-news","10":"tag-genetics","11":"tag-science","12":"tag-uk","13":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/114406807129702004","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/53288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=53288"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/53288\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/53289"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=53288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=53288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=53288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}