Prof Greg Challis, from the University of Warwick’s chemistry department and Melbourne’s Monash University’s Biomedicine Discovery Institute, said: “Methylenomycin A was originally discovered 50 years ago, but no-one appears to have tested the synthetic intermediates for antimicrobial activity. <\/p>\n
“By deleting biosynthetic genes, we discovered two previously unknown intermediates.”<\/p>\n
Researchers also noted that bacteria did not become resistant to it under conditions where resistance would typically emerge which they called an encouraging sign for future use.<\/p>\n
Dr Lona Alkhalaf, assistant professor at Warwick, said the finding was unexpected.<\/p>\n
“The bacterium that makes methylenomycin A \u2014 Streptomyces coelicolor \u2014 is one of the most studied antibiotic-producing species since the 1950s. <\/p>\n
“Finding a new antibiotic in such a familiar organism was a real surprise.”<\/p>\n
“This suggests a new paradigm for antibiotic discovery,” Prof Challis said. <\/p>\n
He said further testing and research may “find potent new antibiotics with more resilience to resistance”. <\/p>\n
The next stage will involve pre-clinical testing of the compound. <\/p>\n","protected":false},"excerpt":{"rendered":"Prof Greg Challis, from the University of Warwick’s chemistry department and Melbourne’s Monash University’s Biomedicine Discovery Institute, said:…\n","protected":false},"author":2,"featured_media":534286,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[105,16,15],"class_list":{"0":"post-534285","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-uk","10":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/115454521209603694","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/534285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=534285"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/534285\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/534286"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=534285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=534285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=534285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}