{"id":959005,"date":"2026-05-14T09:48:36","date_gmt":"2026-05-14T09:48:36","guid":{"rendered":"https:\/\/www.europesays.com\/uk\/959005\/"},"modified":"2026-05-14T09:48:36","modified_gmt":"2026-05-14T09:48:36","slug":"ultrasensitive-biosensing-by-radiative-q-factor-modulation-in-strongly-coupled-three-dimensional-bound-state-in-the-continuum-metasurfaces","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/uk\/959005\/","title":{"rendered":"Ultrasensitive biosensing by radiative Q-factor modulation in strongly coupled three-dimensional bound-state-in-the-continuum metasurfaces"},"content":{"rendered":"
  • \n

    Altug, H., Oh, S.-H., Maier, S. A. & Homola, J. Advances and applications of nanophotonic biosensors. Nat. Nanotechnol. 15<\/b>, 5\u201316 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kabashin, A. V., Kravets, V. G. & Grigorenko, A. N. Label-free optical biosensing: going beyond the limits. Chem. Soc. Rev. 52<\/b>, 6554\u20136585 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Haes, A. J. & Duyne, R. P. V. A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. J. Am. Chem. Soc. 124<\/b>, 10596\u201310604 (2002).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zijlstra, P., Paulo, P. M. R. & Orrit, M. Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod. Nat. Nanotechnol. 7<\/b>, 379\u2013382 (2012).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Shen, Y. et al. Plasmonic gold mushroom arrays with refractive index sensing figures of merit approaching the theoretical limit. Nat. Commun. 4<\/b>, 2381 (2013).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sreekanth, K. V. et al. Extreme sensitivity biosensing platform based on hyperbolic metamaterials. Nat. Mater. 15<\/b>, 621\u2013627 (2016).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhan, C., Liu, B.-W., Tian, Z.-Q. & Ren, B. Determining the interfacial refractive index via ultrasensitive plasmonic sensors. J. Am. Chem. Soc. 142<\/b>, 10905\u201310909 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Park, J.-H. et al. Symmetry-breaking-induced plasmonic exceptional points and nanoscale sensing. Nat. Phys. 16<\/b>, 462\u2013468 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang, Z. et al. Customizing 2.5D out-of-plane architectures for robust plasmonic bound-states-in-the-continuum metasurfaces. Adv. Sci. 10<\/b>, 2206236 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dolia, V. et al. Very-large-scale-integrated high quality factor nanoantenna pixels. Nat. Nanotechnol. 19<\/b>, 1290\u20131298 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rodrigo, D. et al. Mid-infrared plasmonic biosensing with graphene. Science 349<\/b>, 165\u2013168 (2015).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Leitis, A. et al. Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval. Sci. Adv. 5<\/b>, eaaw2871 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhou, H. et al. Dynamic construction of refractive index-dependent vibrations using surface plasmon-phonon polaritons. Nat. Commun. 14<\/b>, 7316 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jia, D. et al. Ultrasensitive infrared spectroscopy via vibrational modulation of plasmonic scattering from a nanocavity. Sci. Adv. 10<\/b>, eadn8255 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Biswas, A. et al. Nanoplasmonic aptasensor for sensitive, selective, and real-time detection of dopamine from unprocessed whole blood. Sci. Adv. 10<\/b>, eadp7460 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bi, X., Czajkowsky, D. M., Shao, Z. & Ye, J. Digital colloid-enhanced Raman spectroscopy by single-molecule counting. Nature 628<\/b>, 771\u2013775 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Balaur, E. et al. Colorimetric histology using plasmonically active microscope slides. Nature 598<\/b>, 65\u201371 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Li, R. et al. Metasurface-driven and nanomaterial-coupled plasmonic biosensor for the rapid and quantitative clinical identification of neutralizing antibodies against SARS-CoV-2 variants. Adv. Funct. Mater. 33<\/b>, 2306145 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Li, F. et al. Affinity exploration of SARS-CoV-2 RBD variants to mAb-functionalized plasmonic metasurfaces for label-free immunoassay boosting. ACS Nano 17<\/b>, 3383\u20133393 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Holze, J., Lauber, F., Soler, S., Kostenis, E. & Weindl, G. Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling. Nat. Commun. 15<\/b>, 9554 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Huhn, A. et al. The molecular reach of antibodies crucially underpins their viral neutralisation capacity. Nat. Commun. 16<\/b>, 338 (2025).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Barth, I. & Lee, H. Nanophotonic sensing and label-free imaging of extracellular vesicles. Light Sci. Appl. 14<\/b>, 177 (2025).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kravets, V. G., Kabashin, A. V., Barnes, W. L. & Grigorenko, A. N. Plasmonic surface lattice resonances: a review of properties and applications. Chem. Rev. 118<\/b>, 5912\u20135951 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jin, J. et al. Topologically enabled ultrahigh-Q guided resonances robust to out-of-plane scattering. Nature 574<\/b>, 501\u2013504 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jahani, Y. et al. Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles. Nat. Commun. 12<\/b>, 3246 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    K\u00fchner, L. et al. Radial bound states in the continuum for polarization-invariant nanophotonics. Nat. Commun. 13<\/b>, 4992 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hu, J. et al. Rapid genetic screening with high quality factor metasurfaces. Nat. Commun. 14<\/b>, 4486 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kang, M., Liu, T., Chan, C. T. & Xiao, M. Applications of bound states in the continuum in photonics. Nat. Rev. Phys. 5<\/b>, 659\u2013678 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Liang, Y., Tsai, D. P. & Kivshar, Y. From local to nonlocal high-Q plasmonic metasurfaces. Phys. Rev. Lett. 133<\/b>, 053801 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Luchansky, M. S. & Bailey, R. C. High-Q optical sensors for chemical and biological analysis. Anal. Chem. 84<\/b>, 793\u2013821 (2012).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Pitruzzello, G. Optical biosensors towards the clinic. Nat. Photonics 18<\/b>, 1126\u20131128 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    K\u00fchne, J. et al. Fabrication robustness in BIC metasurfaces. Nanophotonics 10<\/b>, 4305\u20134312 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Won, R. Plasmonics commercialized? Nat. Photonics 18<\/b>, 895\u2013897 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhang, Y. et al. Momentum-space imaging spectroscopy for the study of nanophotonic materials. Sci. Bull. 66<\/b>, 824\u2013838 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Aigner, A. et al. Plasmonic bound states in the continuum to tailor light-matter coupling. Sci. Adv. 8<\/b>, eadd4816 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Koshelev, K., Lepeshov, S., Liu, M., Bogdanov, A. & Kivshar, Y. Asymmetric metasurfaces with high-Q resonances governed by bound states in the continuum. Phys. Rev. Lett. 121<\/b>, 193903 (2018).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chen, Y. et al. Can weak chirality induce strong coupling between resonant states?. Phys. Rev. Lett. 128<\/b>, 146102 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Weber, T. et al. Intrinsic strong light\u2013matter coupling with self-hybridized bound states in the continuum in van der Waals metasurfaces. Nat. Mater. 22<\/b>, 970\u2013976 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wen, L., Xu, R., Mi, Y. & Lei, Y. Multiple nanostructures based on anodized aluminium oxide templates. Nat. Nanotechnol. 12<\/b>, 244\u2013250 (2017).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang, L. et al. Aluminium surface work hardening enables multi-scale 3D lithography. Nat. Mater. 24<\/b>, 39\u201347 (2025).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Li, C.-Y. et al. Observation of inhomogeneous plasmonic field distribution in a nanocavity. Nat. Nanotechnol. 15<\/b>, 922\u2013926 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ward, D. R., H\u00fcser, F., Pauly, F., Cuevas, J. C. & Natelson, D. Optical rectification and field enhancement in a plasmonic nanogap. Nat. Nanotechnol. 5<\/b>, 732\u2013736 (2010).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sheinfux, H. H. et al. High-quality nanocavities through multimodal confinement of hyperbolic polaritons in hexagonal boron nitride. Nat. Mater. 23<\/b>, 499\u2013505 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Vassiliev, V. & Sumetsky, M. High Q-factor reconfigurable microresonators induced in side-coupled optical fibres. Light Sci. Appl. 12<\/b>, 197 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Prasad, J. et al. Plasmonic core\u2013satellite assemblies as highly sensitive refractive index sensors. J. Phys. Chem. C 119<\/b>, 5577\u20135582 (2015).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Cai, J. et al. Solution-processed large-area gold nanocheckerboard metasurfaces on flexible plastics for plasmonic biomolecular sensing. Adv. Opt. Mater. 7<\/b>, 1900516 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Cetin, A. E. et al. Handheld high-throughput plasmonic biosensor using computational on-chip imaging. Light Sci. Appl. 3<\/b>, e122 (2014).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yoo, D. et al. Plasmonic split-trench resonator for trapping and sensing. ACS Nano 15<\/b>, 6669\u20136677 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Cetin, A. E. et al. Plasmonic nanohole arrays on a robust hybrid substrate for highly sensitive label-free biosensing. ACS Photonics 2<\/b>, 1167\u20131174 (2015).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang, J. et al. All-dielectric crescent metasurface sensor drivenby bound states in the continuum. Adv. Funct. Mater. 31<\/b>, 2104652 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yesilkoy, F. et al. Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces. Nat. Photonics 13<\/b>, 390\u2013396 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gupta, T. D. et al. Self-assembly of nanostructured glass metasurfaces via templated fluid instabilities. Nat. Nanotechnol. 14<\/b>, 320\u2013327 (2019).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Shen, Y. et al. Ultrasmooth gold nanogroove arrays: ultranarrow plasmon resonators with linewidth down to 2 nm and their applications in refractive index sensing. Adv. Funct. Mater. 32<\/b>, 2108741 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Luo, M. et al. High-sensitivity optical sensors empowered by quasi-bound states in the continuum in a hybrid metal\u2013dielectric metasurface. ACS Nano 18<\/b>, 6477\u20136486 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Conteduca, D. et al. Dielectric nanohole array metasurface for high-resolution near-field sensing and imaging. Nat. Commun. 12<\/b>, 3293 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Liu, Z. et al. Phase interrogation sensor based on all-dielectric BIC metasurface. Nano Lett. 23<\/b>, 10441\u201310448 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Watanabe, K. & Iwanaga, M. Nanogap enhancement of the refractometric sensitivity at quasi-bound states in the continuum in all-dielectric metasurfaces. Nanophotonics 12<\/b>, 99\u2013109 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Qiu, S., Zhang, H., Shi, Z., Li, H. & Zhou, Z.-K. Ultrasensitive refractive index sensing based on hybrid high-Q metasurfaces. J. Phys. Chem. C 127<\/b>, 8263\u20138270 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zheng, Y. et al. High quality-factor all-dielectric metacavity for label-free biosensing. Adv. Sci. 12<\/b>, 2410125 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Suebka, S., McLeod, E. & Su, J. Ultra-high-Q free-space coupling to microtoroid resonators. Light Sci. Appl. 13<\/b>, 75 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Im, H. et al. Template-stripped smooth Ag nanohole arrays with silica shells for surface plasmon resonance biosensing. ACS Nano 5<\/b>, 6244\u20136253 (2011).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lee, K.-L. et al. Enhancing surface plasmon detection using template-stripped gold nanoslit arrays on plastic films. ACS Nano 6<\/b>, 2931\u20132939 (2012).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jia, P., Jiang, H., Sabarinathan, J. & Yang, J. Plasmonic nanohole array sensors fabricated by template transfer with improved optical performance. Nanotechnology 24<\/b>, 195501 (2013).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ye, X. et al. Multi-biomarker combination detection system for diagnosis and classification of dry eye disease by imaging of a multi-channel metasurface. Biosens. Bioelectron. 248<\/b>, 115933 (2024).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wu, M. et al. Ultrasensitive molecular detection at subpicomolar concentrations by the diffraction pattern imaging with plasmonic metasurfaces and convex holographic gratings. Adv. Sci. 9<\/b>, 2201682 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Conteduca, D., Quinn, S. D. & Krauss, T. F. Dielectric metasurface for high-precision detection of large unilamellar vesicles. J. Opt. 23<\/b>, 114002 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bolognesi, M. et al. A Fully Integrated miniaturized optical biosensor for fast and multiplexing plasmonic detection of high- and low-molecular-weight analytes. Adv. Mater. 35<\/b>, 2208719 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bolognesi, M. et al. Integrated nanohole array surface plasmon resonance sensing device using a dual-wavelength source. J. Micromech. Microeng. 21<\/b>, 115001 (2011).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Crosby, D. et al. Early detection of cancer. Science 375<\/b>, eaay9040 (2022).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kalluri, R. & LeBleu, V. S. The biology, function, and biomedical applications of exosomes. Science 367<\/b>, eaau6977 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Pan, S. et al. Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy. Nat. Nanotechnol. 16<\/b>, 734\u2013742 (2021).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wu, X. et al. Exosome-templated nanoplasmonics for multiparametric molecular profiling. Sci. Adv. 6<\/b>, eaba2556 (2020).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhao, H. et al. A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples. Nat. Biomed. Eng. 7<\/b>, 135\u2013148 (2023).<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yi, Y. et al. Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection. Nat. Nanotechnol. 20<\/b>, 1079\u20131086 (2025).<\/p>\n

    Article<\/a>\u00a0
    \n     ADS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sun, J. Ultrasensitive biosensing by radiative Q factor modulation in strongly coupled 3D BIC metasurfaces. Zenodo https:\/\/doi.org\/10.5281\/zenodo.19218509<\/a> (2026).<\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"Altug, H., Oh, S.-H., Maier, S. A. & Homola, J. Advances and applications of nanophotonic biosensors. Nat. Nanotechnol.…\n","protected":false},"author":2,"featured_media":959006,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3845],"tags":[14906,3968,20452,20454,166342,170565,74,11112,70,16,15],"class_list":{"0":"post-959005","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-physics","8":"tag-applied-and-technical-physics","9":"tag-general","10":"tag-metamaterials","11":"tag-nanophotonics-and-plasmonics","12":"tag-optical-sensors","13":"tag-optoelectronic-devices-and-components","14":"tag-physics","15":"tag-quantum-physics","16":"tag-science","17":"tag-uk","18":"tag-united-kingdom"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@uk\/116572304507196769","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/959005","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/comments?post=959005"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/posts\/959005\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media\/959006"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/media?parent=959005"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/categories?post=959005"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/uk\/wp-json\/wp\/v2\/tags?post=959005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}