The San Francisco 49ers (3-1) visit the Los Angeles Rams (3-1) at SoFi Stadium in Inglewood for a Week 5 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Thursday, October 2, including live updated odds and injury report news.
Rams vs. 49ers live odds, moneyline, over/under
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Rams vs. 49ers picks against the spread
Jon Hoefling: Los Angeles Rams (-5.5)
The 49ers were the worst 3-0 team in the league coming into Week 4 and were a bit exposed against a Jacksonville team they had many opportunities to beat.
Tyler Dragon: Los Angeles Rams (-5.5)
The 49ers are dealing with multiple injuries and a short week to prepare. Big advantage Rams.
Richard Morin: San Francisco 49ers (+5.5)
It’s too big a spread for this NFC West matchup. Both games between the teams last season were decided by six points or fewer, so I’ll take the 49ers to cover.
Lorenzo Reyes: Los Angeles Rams (-5.5)
Brock Purdy’s status is still up in the air, and the Rams have been a solid play, going 3-1 against the spread this year, including a perfect 2-0 at home. I’d wait until we get more clarity on Purdy, but on a short week, the Niners might opt to wait a little longer.
Blake Schuster: Los Angeles Rams (-5.5)
Even with Purdy back in the lineup, a banged-up 49ers team traveling on a short week is just too risky.
Christopher Bumbaca: Los Angeles Rams (-5.5)
Home teams on Thursday night make too much sense. As the Niners’ injuries mount, the Rams shall pounce.
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