Ashton Jeanty became the highest running back selected in an NFL Draft since Saquon Barkley in 2018 when the Raiders selected the running back from Boise State No. 6 overall in the 2025 NFL Draft. Barkley rushed for 1,307 yards and had 15 total touchdowns in his rookie campaign, and Fantasy football players and sports bettors expected similar production from Jeanty. After failing to reach 65 total yards with just one touchdown in his first three games, some began to panic, but the rookie responded with 138 rushing yards and three total touchdowns last week against the Bears. After that performance, the SportsLine Machine Learning Model has Jeanty as an anytime touchdown scorer at -115 odds at FanDuel as one of its best values for Week 5 anytime TD scorer bets.
Targeting anytime touchdown bets is one way to approach Week 5 NFL betting at online sports betting sites. With NFL props available for almost every player in every game at sportsbooks, the SportsLine Machine Learning Model can help you find value to add to your Week 5 NFL picks. It can also help new users take advantage of sportsbook promos like the latest FanDuel promo code, where new users receive $300 in bonus bets if your first bet wins.
Best Week 5 NFL anytime touchdown picks:
- Ashton Jeanty, Raiders, (-110)
- De’Von Achane, Dolphins (-135)
- Amon-Ra St. Brown, Lions (-105)
Parlay these picks for +521 odds with a DraftKings promo code, which gives new users $200 in bonus bets if your first bet of $5 or more wins: (odds subject to change)
Ashton Jeanty, Raiders (-110)
Last week was the performance Jeanty supporters have been waiting for since the day he was drafted. The No. 6 overall pick in the 2025 NFL Draft rushed for 138 yards and a touchdown, nearly surpassing his rushing total from the first three weeks (144 yards). Jeanty also had two receiving touchdowns in a 25-24 loss to the Bears. Jeanty rushed for 29 touchdowns in 14 games at Boise State last season, and now with four touchdowns in four games after last week’s emergence, sports bettors should feel more confident backing the Raiders running back.
The Raiders play the Colts, who allowed 5.9 yards per carry to Rams running back Kyren Williams last week. Indianapolis allowed a rushing touchdown to the opposing team’s RB1 in three of the first four weeks of the season. Jeanty played 85% of snaps last week, and given his workload, matchup and breakout performance last week, the model sees value in Jeanty in Week 5 anytime TD scorer bets. FanDuel is offering Jeanty at -110 odds, while other sportsbooks have him around -125 odds, and with the latest FanDuel promo code, new users receive $300 in bonus bets if your first $5 bet wins.
De’Von Achane, Dolphins (-135)
The Miami running back has also been a featured part of the team’s passing attack in the majority of games with Tua Tagovailoa healthy, but following last week’s injury to Tyreek Hill, the Dolphins may need him to take on an even larger role in all facets of the game. Achane had a season-high 20 carries last week against the Jets, resulting in 99 yards and a touchdown. Achane had at least nine targets in two of his first three games, with two receiving touchdowns during that span. The 23-year-old has scored a touchdown in two of three games this season.
Miami plays the Panthers, who had the worst scoring defense in the NFL last season. Carolina ranks 19th in scoring defense (23.8 points per game allowed) this season, and allowed rushing touchdowns to three different players last week in a 42-13 loss to the Patriots, including two running backs. No Patriots running back played more than 57% of snaps last week, while Achane has played at least 73% of snaps in all four games this week. Given his likely increased offensive involvement and this matchup, the model sees value in Achane finding the end zone in some capacity on Sunday. DraftKings is offering Achane at -135 odds, and with the latest DraftKings promo code, new users can receive $200 in bonus bets if your first bet of $5 or more wins.
Amon-Ra St. Brown, Lions (-105)
St. Brown had two touchdowns against the Browns last week, and he leads the NFL with six scores through four weeks. He’s scored all six of those touchdowns in the last three weeks, with at least one touchdown in each of those contests, as one of the most important players to any offense in the NFL. He had 22 touchdowns over the previous two seasons, and he remains a top target for Jared Goff this fall.
St. Brown has secured 27 of 32 targets (84.4%) through four weeks to showcase his indelible connection with Goff. The Lions are 10.5-point favorites against the Bengals with one of the largest implied point totals of the weekend. Cincinnati has allowed at least 27 points in three straight weeks and ranks 27th in scoring defense on the season at 29.8 ppg against. Caesars Sportsbook offers St. Brown at -105 odds to score a touchdown, while some betting apps have him at -105 odds or greater, and with the latest Caesars Sportsbook promo code CBS20X, new users can receive 20 100% profit boost tokens with their first $1 bet.
Want more Week 5 NFL picks?
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You can also see the model’s best bets for every Week 5 NFL game, including Commanders vs. Chargers, Patriots vs. Bills and Titans vs. Cardinals. Finally, SportsLine expert RJ White, who is 42-29 (+1490) over his last 71 NFL picks, has locked in multiple Week 5 NFL picks. Visit SportsLine to see his best bets.
Want more huge paydays? The model has also built a five-leg Week 5 NFL parlay that would pay at nearly 25-1 odds. Check out the model’s Week 5 NFL parlay only at SportsLine. Visit SportsLine to see the parlay.