The San Francisco 49ers hit the highway on Sunday to take on the Tampa Bay Buccaneers.

Mac Jones threw during Friday’s practice. That’s a step in the right direction after Jones didn’t attempt any passes during Thursday’s practice.

Ricky Pearsall and Brock Purdy did not practice once again. Meanwhile, Jauan Jennings was present and active during today’s session.

Here’s a look at the 49ers’ final injury report:

Brock Purdy (toe)
Ricky Pearsall (knee)
Yetur Gross-Matos (knee/hamstring)
Robert Beal (ankle)
Jordan Watkins (calf)
Kevin Givens (pec)

Mac Jones (oblique/knee)
Jauan Jennings (ribs/ankle)
Alfred Collins (knee)
Upton Stout (ankle)
Kalia Davis (hand)
Malik Mustapha (knee)

Adrian Martinez will serve as Mac Jones’ backup once again, unless the team signs one of the three quarterbacks they worked out on Friday: Desmond Ridder, Nathan Peterman, or Quinten Dormady. Per NFL Network’s Tom Pelissero, the 49ers didn’t sign either of them…yet.

This could be viewed as them wanting an upgrade over Adrian Martinez in the event he has to play because Mac Jones goes down with an injury. The team has had a few weeks to gauge whether he Martinez can run the offense or not.

Collins and Stout practicing is another positive development for a defense that can’t afford to miss anymore bodies.

Shanahan didn’t sound like he was concerned about Mac Jones’ availability: “I pretty much already have. But you gotta put it that way if there’s any doubt at all.”

The team also intends to open rookie Kurtis Rourke’s practice window soon. Shanahan said Rourke is “probably a few weeks away” from practicing. The rookie quarterback is returning from a torn ACL injury.

Mustapha’s role and how it impacts the rest of the roster will be something we’re keeping an eye on. Will Robert Saleh let rookie Marques Sigle continue to take his lumps, or does he roll with the veteran, Jason Pinnock?

Head coach Todd Bowles ruled out a pair of cornerbacks, two of Baker Mayfield’s favorite targets, and their big-play running back:

WR Mike Evans
WR Chris Godwin
RB Bucky Irving
CB Zyon McCollum
CB Benjamin Morrison

Iriving didn’t practice all week. He’s battling multiple injuries and was last seen in a walking boot.

Evans will miss his third game in a row with a hamstring injury. Godwin suffered a fibula injury against the Seattle Seahawks last week. He missed the first three games after recovering from a dislocated ankle last season that required reconstructive surgery.

The 49ers still have to go against rookie wide receiver Emeka Egubuka and attempt to keep him out of the end zone. Egbuka has been electric to start the season. But now he’ll have to do it with Sterling Shepard and Tez Johnson as the other wide receivers on the field.

McCollum has started at cornerback in every game this season for the Bucs. Starting cornerback Jamel Dean was a full participant during Thursday’s practice after missing Week 5. So Tampa Bay will lose one starter but get another back. Dean is their CB1.

Morrison was Tampa Bay’s second-round draft pick in 2025. He’s filled in when one of the other cornerbacks suffered an injury. He’ll miss his second game in a row. Morrison held up well against AJ Brown and the Philadelphia Eagles two weeks ago before injury.

Morrison’s absence means musical chairs in the secondary for the Bucs. Rookie Jacob Parrish goes from playing nickel to the outside. On passing downs, Kindle Vildor was the next cornerback in. Week 5 was Vildor’s first defensive snaps of the season.