Three people have died after two SUVs collided on a rural road in the Macedon Ranges, north-west of Melbourne.

The crash took place on Bolinda-Darraweit Road in Bolinda about 7.20am on Sunday.

A wheel and other debris from a car lie on the grass beside a farm fence.

Debris from the crash was scattered across the road. (ABC News)

Police said three people from one of the vehicles died at the scene.

A fourth from the same car was flown to hospital with life-threatening injuries.

They were yet to be formally identified.

Many police officers in dark uniforms and bright yellow vests stand around two ambulances.

Emergency services were called to the scene around 7.20am on Sunday.

The driver and sole occupant of the second vehicle was taken to hospital with non-life-threatening injuries.

The exact circumstances surrounding the collision are yet to be determined and investigations remain ongoing.

The crash has taken Victoria’s road toll for the year to 152 people, 11 more than at the same time last year.

An aerial shot of police, ambulance and SES vehicles parked on the side of a road bordered by trees and a paddock.

The crash happened in the small Macedon Ranges locality of Bolinda. (ABC News)

Anyone who witnessed the incident, has dashcam footage or any other information that could help police in their investigations is urged to contact Crime Stoppers on 1800 333 000 or www.crimestoppersvic.com.au.