The Jacksonville Jaguars (11-4) take a six-game winning streak into their contest with the Indianapolis Colts on Sunday, December 28, 2025 at Lucas Oil Stadium. The Jaguars are listed as favorites in this one, with the spread sitting at 5.5 points. The over/under is 48.5 in the contest.
Facing the Denver Broncos in their most recent game, the Jaguars won 34-20.
The Jags’ Trevor Lawrence went 23-for-36 for 279 yards against the Broncos, with three TDs and no INTs.
The Colts lost to the San Francisco 49ers, 48-27, in their last game.
Jaguars vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 1:39 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread favorite: Jacksonville (-5.5)
- Moneyline: Jacksonville (-256), Indianapolis (+208)
- Total: 48.5 points
Jaguars betting insights
- Jacksonville is 5-2 overall, and 4-3 against the spread, away from home.
- The Jaguars have covered the spread in a matchup 10 times this season (10-5-0).
- On the road, Jacksonville is unbeaten ATS (1-0) as 5.5-point favorites or more.
- The Jaguars have a perfect 2-0 ATS record when playing as at least 5.5-point favorites.
- In six of seven road games this year, Jacksonville has gone over the total.
- This season, nine Jaguars games have gone over the point total.
Jaguars leaders
- Lawrence: 3,489 PASS YDS / 232.6 YPG / 60% / 26 TD / 11 INT / 72 CAR / 322 RUSH YDS / 7 TD
- Travis Etienne: 229 CAR / 999 YDS / 66.6 YPG / 7 TD / 33 REC / 270 YDS / 18 YPG / 6 TD
- Jakobi Meyers: 64 REC / 752 YDS / 53.7 YPG / 3 TD
- Parker Washington: 45 REC / 645 YDS / 46.1 YPG / 4 TD
- Brian Thomas: 41 REC / 619 YDS / 51.6 YPG / 2 TD
Jaguars vs Colts game info
- Date: Sunday, December 28, 2025
- Time: 1 p.m. ET
- City: Indianapolis, Indiana
- Venue: Lucas Oil Stadium
- TV channel: FOX
- Live stream: Watch on Fubo (Regional restrictions may apply)
Watch Jacksonville Jaguars vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)