April 22, 2026Updated 6:15 am EDT

The Cleveland Guardians and Houston Astros square off on Wednesday at 1:10 p.m. ET at Progressive Field, attempting to break a 1-1 series tie. Tanner Bibee (0-2, 4.81 ERA) gets the start for the Guardians, who are 14-11 this season and first in the AL Central. Peter Lambert (0-1, 7.20 ERA) is the expected starter for the Astros, who are 9-16 and fifth in the AL West.

How to watch Houston Astros vs. Cleveland GuardiansAstros vs. Guardians odds

Odds provided by BetMGM.

Injury reportsGuardians

Gabriel Arias: 10 Day IL (Hamstring), Andrew Walters: 15 Day IL (Lat)

Astros

Joey Loperfido: 10 Day IL (Quadricep), Jake Meyers: 10 Day IL (Oblique), Zach Dezenzo: 10 Day IL (Elbow), Taylor Trammell: 10 Day IL (Groin), Jeremy Pena: 10 Day IL (Knee), Nick Allen: 10 Day IL (Back), Cody Bolton: 15 Day IL (Back), Hunter Brown: 15 Day IL (Shoulder), Nate Pearson: 15 Day IL (Elbow), Tatsuya Imai: 15 Day IL (Arm), Bennett Sousa: 15 Day IL (Oblique), Cristian Javier: 60 Day IL (Shoulder), Hayden Wesneski: 60 Day IL (Elbow), Ronel Blanco: 60 Day IL (Elbow), Brandon Walter: 60 Day IL (Elbow), Josh Hader: 60 Day IL (Biceps), Dustin Harris: day-to-day (Hand)

Stats to know

  • Jose Ramirez is hitting for a .233 BA, .367 OBP and .489 SLG with a 12.8% strikeout rate and a 17.4% walk rate. His OPS is .856 and he has scored 18 runs. In 109 plate appearances, he has hit six home runs (16th in MLB) and driven in 12 runs. Ramirez has been crafty on the base paths, recording 11 steals on 11 attempts.
  • In 90 plate appearances, Chase DeLauter has slashed .221/.322/.506 this season. He has hit five long balls and driven in 15 runs with a strikeout rate of 12.2% and a walk rate of 13.3%. He has come around to score 12 times.
  • Houston’s Yordan Alvarez is slashing .330/.456/.747 this season with 10 home runs (1st in MLB), 24 RBIs (1st in MLB) and an OPS of 1.203 (2nd in MLB). He has a 9.6% strikeout rate and a 16.7% walk rate in 114 plate appearances, and he has scored 19 total runs.
  • In 102 plate appearances, Christian Walker has slashed .261/.353/.511 this season. He has hit five long balls and driven in 18 runs (13th in MLB) with a strikeout rate of 16.7% and a walk rate of 11.8%. and has scored 16 runs.

This watch guide was created using technology provided by Data Skrive.

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Photo: Jamie Squire, Ishika Samant, Scott Taetsch, Alika Jenner / Getty Images

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Apr 22, 2026

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