A multi-vehicle crash stopped all lanes of eastbound traffic on State Route 94 at Federal Boulevard for about an hour and a half on Thursday afternoon, Caltrans said.
The collision was expected to stop traffic for up to one hour, according to Sigalert.
By about 5:40 p.m., some lanes were reopened, California Highway Patrol said.
Traffic was reportedly backed up to 25th Street.
The details of the crash were not immediately available.