The Jacksonville Jaguars are set to hit the road to face off against the San Francisco 49ers on Sunday in the teams’ Week 4 matchup.

Coming off a narrow victory over divisional rival Houston Texans, Jacksonville’s overall roster health took a slight hit, but progressed as the week continued.

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The major injury this week was to receiver Dyami Brown, who sustained a shoulder injury as halftime approached against Houston. Brown did not practice on Wednesday, but did participate on a limited basis the next two days.

After listing six players on the team’s initial report, just two players — Brown and Milum — received an injury designation, meaning the rest of the team’s injured players are good to go. Among those are receiver Brian Thomas Jr. (wrist) and running back Bhayshul Tuten (shoulder).

It should be noted that Thomas has practiced fully every practice this season except one last week due to a sore wrist. Tuten has sported an orange non-contact penny in practice the last two weeks. The ailment has not appeared to hinder his availability, however.

PREDICTIONS: Our 3 boldest Jacksonville Jaguars predictions vs. 49ers in Week 4

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Here are the latest Jacksonville Jaguars injury updates.

Jaguars injury report

  • WR Dyami Brown (shoulder) – Questionable

  • LB Yasir Abdullah (hamstring) – Questionable

  • G Wyatt Milum (knee) – Out

Dyami Brown questionable to play vs. 49ersJacksonville Jaguars wide receiver Dyami Brown (5) hauls in a pass while running a route during the Jaguars 14th NFL training camp session at Miller Electric Center Tuesday August 12, 2025 in Jacksonville, Fla. The Jaguars travel to New Orleans to play the Saints this Sunday in their second preseason game. [Doug Engle/Florida Times-Union]

Jacksonville Jaguars wide receiver Dyami Brown (5) hauls in a pass while running a route during the Jaguars 14th NFL training camp session at Miller Electric Center Tuesday August 12, 2025 in Jacksonville, Fla. The Jaguars travel to New Orleans to play the Saints this Sunday in their second preseason game. [Doug Engle/Florida Times-Union]

Brown has been a key player for Jacksonville, matching the number of starts he had all of last season with the Washington Commanders in Jacksonville this year (three). He’s caught 10 passes for 116 yards and a touchdown on 14 targets.

Brown had been one of the most consistent players during the team’s offseason program and training camp and appeared to develop a good chemistry with quarterback Trevor Lawrence. He also has shown an ability to handle runs or end arounds, totalling three rushes for 15 yards and a first down this year.

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If Brown can’t play, look for receivers Tim Patrick and Parker Washington to help carry the load, while it appears second-overall pick, WR/CB Travis Hunter, won’t necessarily be impacted by Brown’s potential absence.

Demetrius Harvey is the Jacksonville Jaguars reporter for the Florida Times-Union. You can follow him on X, formerly known as Twitter, at @Demetrius82 or on Bluesky @ Demetrius.

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This article originally appeared on Florida Times-Union: Jaguars injury report shows Dyami Brown questionable, 1 ruled out