More than 60 firefighters and 20 fire trucks have worked to contain a blaze at a timber flooring factory in Sydney‘s west.

Emergency services were called to the fire at Claremont Avenue in Greenacre just before 3pm today.

An exclusion zone has been set up and motorists are urged to avoid the area.

Firefighters are at the scene of a factory fire in Sydney's west.Firefighters are at the scene of a factory fire in Sydney’s west. (9News)

Fire and Rescue NSW Adam Dewberry said there were no reports of injuries, but due to the intensity of the blaze, it spread to adjoining businesses, the exact damage is still unknown as the fire is still smouldering.

“We have property at risk on the side and to the rear of the property,” he said.

“We’ve had roof and some wall collapse.”

“One of the complexities with this particular operation was not only the fuel loading being furniture and timber, (but also) the difficulty in getting significant water up into the fire trucks and onto the water,” Dewberry said.

“Fire and Rescue New South Wales had to pump water from a distance in other streets of other big mains to get enough water on the fire.”

More than 50 firefighters are on scene battling the blaze.More than 50 firefighters are on scene battling the blaze. (Fire and Rescue NSW)

NSW Police and NSW Ambulance paramedics were also at the scene.

People are being urged to avoid the area and keep any doors and windows closed if they live nearby.

The cause of the blaze remains unknown.