Iran launched missiles at Israel in the first such bombardment since a fragile ceasefire took effect in early April, raising the possibility of a return to heavy fighting and complicating mediation efforts to end the war.

Iran’s state broadcaster confirmed the launches, and Iran closed its western airspace to brace for a possible response. Tehran had warned of retaliation after Israel struck Beirut’s southern suburbs without warning earlier Sunday in defiance of Washington’s request days ago to stand down. Israel said Iranian-backed Hezbollah fired at northern Israel earlier in the day.

“Should these acts of aggression be repeated, the responses will be broader in scope and will encompass all American and Zionist targets throughout the region,” Iran’s Islamic Revolutionary Guard Corps said in a statement that referenced attacks in Lebanon and on Iran’s coast and vessels around the Strait of Hormuz.

Sirens sounded in several areas of Israel, sending millions running for shelter. Israel’s military said it intercepted the missiles, and multiple explosions were heard in the north. Less than an hour later, the military said people could leave areas reinforced against missile attacks.

“Iran has made a grave mistake,” Israeli military spokesperson Brig. Gen. Effie Defrin said. The military’s chief of staff, Lt. Gen. Eyal Zamir, said it will “strike the enemy with determination as soon as the order is given.”

But Israel’s public broadcaster, Kan, said President Trump told it that he doesn’t think Israel needs to respond further.

Iran had warned that an attack on Beirut would renew full-scale war across the Mideast, even as Pakistan and other mediators try to restart talks between Tehran and Washington.

“U.S. forces across the Middle East remain vigilant and ready,” the U.S. Central Command posted on X shortly before the missile launches.

Israel’s attack on Beirut came a few days after the Lebanese and Israeli governments agreed to a ceasefire in U.S.-hosted talks, though Hezbollah rejected the deal. The strike on a residential building killed two people and wounded 20, Lebanon’s Health Ministry said.

“The army will continue to act in all of Lebanon,” the Israeli military spokesperson said.

Israel’s strikes and ground invasion in Lebanon in pursuit of Hezbollah, and the militant group’s resistance to disarming, have complicated an overall deal to end the war in the Middle East.

Iran says any deal must include an end to fighting in Lebanon.

Trump told a Fox News Channel reporter that he wanted the Iranians to stop firing missiles and return to the negotiating table. He also said that Israel’s strikes earlier Sunday were not coordinated with the U.S. and “I’m not happy about it.”

Early last week, Israel had announced that it would strike the southern suburbs of Lebanon’s capital, but urgent talks via Washington halted that plan on the condition that Hezbollah stop targeting Israeli border towns.

Hezbollah, which claimed responsibility for firing at Israel earlier Sunday, wants the direct talks between Lebanon and Israel to end and instead supports Iran’s stance that an overall ceasefire deal between Tehran and Washington must include the situation in Lebanon.

Israeli Prime Minister Benjamin Netanyahu, who faces elections this year, wants to press ahead with Israel’s offensive until he believes Hezbollah no longer poses a threat, which has paralyzed life for thousands of residents along Israel’s northern border.

But Trump has made clear he does not want to see the fighting resume.

Trump said earlier Sunday in an interview with NBC’s “Meet the Press” that he would like to see a “more surgical attack on Hezbollah.” He also said he was “not demanding” that Lebanon be part of an overall ceasefire deal in the Iran war.

Iran continues to assert its grip on the Strait of Hormuz and the U.S. continues its blockade of Iranian ports, with shipments of oil, natural gas and fertilizer affected and the global economy in pain.

Since the ceasefire took effect, Iran has launched missiles and drones at Persian Gulf nations and said it was targeting the U.S. military presence. After Iran’s launches against Israel, Iraq’s Civil Aviation Authority announced that Iraq’s airspace would close for 72 hours and Syria’s aviation authority announced a 12-hour airspace closure.

All flights from Tehran’s main international airport were suspended, the civil aviation authority said, according to the official Mizan news agency.

Diplomacy continues

Pakistan’s interior minister, Mohsin Naqvi, was in Tehran on Sunday delivering a message to Iranian Supreme Leader Ayatollah Mojtaba Khamenei from Pakistan’s army chief Field Marshal Asim Munir, according to Iran’s state-run IRNA news agency. There were no details on the message’s contents.

Khamenei has not been seen in public since he was named the Islamic Republic’s ruler after his father was killed on Feb. 28, the first day of the war.

Pakistani authorities have said Islamabad, with support from regional countries including Qatar, Turkey and Egypt, is working to help bridge differences between the United States and Iran.

In Cairo, Egyptian Foreign Minister Bader Abdelatty and Qatari counterpart Sheikh Mohammed bin Abdulrahman al Thani discussed “proposed elements” of a potential agreement between the U.S. and Iran, the Egyptian Foreign Ministry said, without providing details.

And after Iran’s missile launches at Israel, Iranian Foreign Minister Abbas Araghchi spoke with counterparts in France, Qatar, Saudi Arabia, Britain, Egypt and Turkey as well as Pakistan’s army chief of staff, Iranian state TV said.

Chehayeb, Magdy, Lidman and Anna write for the Associated Press and reported from Beirut, Cairo, Tel Aviv, and Lowville, N.Y., respectively. AP writers Hassan Ammar in Lebanon; Munir Ahmed in Islamabad; Matthew Lee in Washington; Abby Sewell in Beirut and Michelle L. Price in Bridgewater, N.J., contributed to this report.