Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans
Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42,…
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Data retrieval, curation and proteome database reconstructioneTOLDB construction To guide dataset selection and LECA reconstruction, we used the…
Distinct genetic architecture in the tails of complex traits
Data processingUKB genotype data The UKB is a prospective cohort study of approximately 500,000 participants recruited across the…
Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Darwin, C. On the Origin of Species (Cambridge Univ. Press, 1859). Simpson, G. G. The Major Features of…
Chromosomal fusions trigger rediploidization of autopolyploid genomes
Ohno, S. Evolution by Gene Duplication (Springer, 1970). Dehal, P. & Boore, J. L. Two rounds of whole…
EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk
Study participants Participants from southern China were enrolled through two independent recruitments (sample sets 1 and 2). Participants…
Tumour promotion through the lens of evolution
Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23–28 (1976). Article CAS PubMed ADS …
Ancient DNA reveals pervasive directional selection across West Eurasia
Liu, Y., Mao, X., Krause, J. & Fu, Q. Insights into human history from the first decade of…
Homo sapiens-specific evolution unveiled by ancient southern African genomes
Nielsen, R. et al. Tracing the peopling of the world through genomics. Nature 541, 302–310 (2017). Article ADS …
The genetics of extrinsic postzygotic selection in a migratory divide between subspecies of the Swainson’s thrush
Coyne, J. A. & Orr, H. A. Speciation. (Sinauer Associates, Inc., Sunderland, 2004). Grant, B. R. & Grant,…