Diversity and evolution of chromatin regulatory states across eukaryotes
Struhl, K. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell 98, 1–4 (1999). CAS PubMed …
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, LabEx DISTALZ—U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies…
Non-Mendelian inheritance of DNA methylation patterns in mice
Integrated genetic and epigenetic analysis of the intergenerational inheritance of DNA methylation patterns We designed a combined genetic…
Genetic association and machine learning improve the prediction of type 1 diabetes risk
Ethics statement The use of human genetic data in this study was approved by the University of California,…
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo, M. S. et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat. Rev. Dis. Primers 5,…
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
Vermunt, M. W., Zhang, D. & Blobel, G. A. The interdependence of gene-regulatory elements and the 3D genome.…
Biallelic variants in RNU2-2 cause the most prevalent known recessive neurodevelopmental disorder
Genetic association analysis We identified the recessive form of RNU2-2 syndrome through a joint statistical analysis of the…
Single-cell spatial transcriptomic analysis of human skin anatomy
A single-cell spatial MERFISH atlas of normal human skin To map the cellular and spatial diversity of human…
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions
FTLD-FET consortium We established an international consortium to identify and bring together a sufficiently large case population to…