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How we smell is not just a matter of taste \u2013 it\u2019s also influenced by our genes. An international team of researchers led by scientists from Leipzig University has conducted the largest genetic study to date on the human sense of smell. Researchers at the Institute for Medical Informatics, Statistics and Epidemiology (IMISE) identified seven new genetic regions associated with our ability to perceive odours. In the long term, the findings could help improve understanding of olfactory disorders and enable earlier detection of diseases. The scientific paper has been published in Nature Communications.<\/p>\n
The sense of smell is the least researched of our senses \u2013 despite the fact that olfactory disorders can significantly impair quality of life and may provide important clues to underlying illnesses. The study analysed the genetic basis of the sense of smell in over 21,000 people of European descent. Particular attention was paid to potential differences between women and men. To this end, researchers used so-called genome-wide association studies, in which the genetic material of large numbers of individuals is compared.<\/p>\n
Links between the sense of smell, Alzheimer\u2019s and hormones<\/p>\n
\u201cWe identified ten genetic regions associated with the ability to detect specific odours \u2013 seven of these are new discoveries. Three of the regions also show sex-specific effects, meaning they function differently in men and women,\u201d explains Professor Markus Scholz, lead researcher of the study from the Institute for Medical Informatics, Statistics and Epidemiology at Leipzig University. The findings help to explain why women, for example, perceive smells differently during their menstrual cycle or pregnancy. They could also support efforts to tailor medical diagnoses more closely to biological sex.<\/p>\n
Another key finding of the study: \u201cThere is a link between the risk of Alzheimer\u2019s disease and the ability to detect odours. This strengthens the evidence that the sense of smell, sex hormones and neurodegenerative diseases are interconnected,\u201d says Franz F\u00f6rster, first author of the study and an early career researcher at the Faculty of Medicine. The genetic effects identified in the current analysis were each limited to individual odours \u2013 there was no single \u201cuniversal genetic locus\u201d that influenced the perception of multiple smells.\u00a0<\/p>\n
Identifying everyday smells using scent pens<\/p>\n
In the Leipzig LIFE Adult Study and other partner studies, participants were asked to identify twelve different everyday smells presented using special scent pens. Their responses were compared with genetic data and analysed in a large-scale meta-analysis led by the Institute for Medical Informatics, Statistics and Epidemiology.\u00a0<\/p>\n
An even larger study is currently under way as part of the\u00a0German National Cohort (NAKO Gesundheitsstudie)<\/a>, in which Leipzig University is also involved. Around 200,000 people are taking part. Researchers at the Institute for Medical Informatics, Statistics and Epidemiology hope this will soon allow them to examine genetic and sex-specific differences in the sense of smell in even greater detail.<\/p>\n Reference:\u00a0<\/b>F\u00f6rster F, Emmert D, Horn K, et al. Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants. Nat Commun. 2025;16(1):5434. doi: 10.1038\/s41467-025-61330-y<\/a><\/p>\n This article has been republished from the following materials<\/a>. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"
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