Frailty \u2013 a condition in which the body loses its resilience and becomes more vulnerable to falls, infections and other stresses \u2013 increases the risk of hospitalisation and death. Understanding why some people are affected earlier than others can therefore be of great importance.<\/p>\n
In a comprehensive genetic analysis of nearly one million people in Finland and the United Kingdom, researchers have found genetic variants linked to frailty. By analysing the participants’ DNA and health data, the researchers were able to identify hundreds of genetic markers that influence the risk of developing the condition.<\/p>\n
\u201dOur results show that frailty is not caused by a single factor, but by many genes that affect how our immune system, brain and metabolism work. Some of these genes are completely new discoveries,\u201d says last author\u00a0Juulia Jylh\u00e4v\u00e4<\/a>, associate professor at the\u00a0Department of Medical Epidemiology and Biostatistics<\/a>, Karolinska Institutet.<\/p>\n The results show that a person’s genetic risk of frailty can be measured \u2013 and ultimately used to predict who is at increased risk of becoming ill or needing care, according to the researchers.<\/p>\n \u201dIn the future, we may be able to identify people who are at risk as early as middle age, when there is still time to prevent frailty. This opens the door to new ways of improving health in older people,\u201d concludes Juulia Jylh\u00e4v\u00e4.<\/p>\n The study was conducted in collaboration with Tampere University in Finland. See the study for funders and any conflicts of interest.<\/p>\n Reference:<\/b> Mak JKL, Qin C, Kr\u00fcger M, et al. Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty. Nat Aging. 2025:1-12. doi:\u00a0\u00a010.1038\/s43587-025-00925-y<\/a><\/p>\n This article has been republished from the following materials<\/a>. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Frailty \u2013 a condition in which the body loses its resilience and becomes more vulnerable to falls, infections…\n","protected":false},"author":3,"featured_media":123111,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[815,159,67,132,68],"class_list":{"0":"post-123110","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-united-states","11":"tag-unitedstates","12":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/114980825517946385","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/123110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=123110"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/123110\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/123111"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=123110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=123110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=123110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}