{"id":218392,"date":"2025-09-11T14:41:15","date_gmt":"2025-09-11T14:41:15","guid":{"rendered":"https:\/\/www.europesays.com\/us\/218392\/"},"modified":"2025-09-11T14:41:15","modified_gmt":"2025-09-11T14:41:15","slug":"wegovy-and-zepbound-cost-effective-but-they-could-break-drug-budgets","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/218392\/","title":{"rendered":"Wegovy And Zepbound Cost Effective But They Could Break Drug Budgets"},"content":{"rendered":"\n

The Institute for Clinical and Economic Review (ICER) on Tuesday released a Draft Evidence Report assessing the comparative clinical effectiveness and value of Novo Nordisk A\/S\u2019 (NYSE:NVO<\/a>) semaglutide (Wegovy) and Eli Lilly and Co.\u2019s<\/strong> (NYSE:LLY<\/a>) tirzepatide (Zepbound) for obesity management.<\/p>\n

ICER is also assessing how these treatments affect\u00a0additional\u00a0obesity-related outcomes.<\/p>\n

In a draft\u00a0report, the ICER determined that the drugs are cost-effective because, when added on to lifestyle modification, provide greater clinical benefits than lifestyle modification alone, including reducing metabolic risk factors and addressing obesity-related health complications.<\/p>\n

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The drug pricing group analyzed Novo Nordisk\u2019s injectable semaglutide at the 2.4 mg dose, its investigational oral semaglutide 25 mg dose, and Eli Lilly\u2019s injectable 15 mg dose of tirzepatide.<\/p>\n

The report said that although these treatments increase intervention costs, they yield long-term savings in non-intervention costs. At current net prices, their incremental cost-effectiveness ratios were below commonly used cost-effectiveness thresholds.<\/p>\n

\u201cBecause treatment with all three drugs results in substantial weight loss and improvement in metabolic risk factors, we have high certainty that all three drugs have substantial net health benefit over lifestyle modifications alone,\u201d ICER reported.<\/p>\n

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The report noted Lilly\u2019s tirzepatide a \u201cpromising but inconclusive\u201d designation when comparing its profile against the two versions of semaglutide, while oral semaglutide was given a \u201ccomparable or worse\u201d assessment compared with its injectable drug, highlighting lower weight loss results and an uncertain cardio risk reduction.<\/p>\n

ICER used the estimated cost for a year of semaglutide, which was $6,829, down from $13,618 in the 2022 model, and for tirzepatide, it was $7,973.<\/p>\n

Despite its glowing cost-effectiveness analysis, ICER flagged \u201cserious\u201d concerns about affordability. ICER report adds that fewer than 1% of eligible patients can be treated before the drugs cross their \u201cbudget impact threshold\u201d of $880 million annually.<\/p>\n

ICER solicits comments on the report until October 6 and plans to hold a virtual public meeting on its findings in November.<\/p>\n

Read Next:<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"The Institute for Clinical and Economic Review (ICER) on Tuesday released a Draft Evidence Report assessing the comparative…\n","protected":false},"author":3,"featured_media":218393,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[115916,25996,210,116605,70576,119220,1060,119221,9412,15209,119222,67,132,68],"class_list":{"0":"post-218392","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-medication","8":"tag-clinical-effectiveness","9":"tag-eli-lilly","10":"tag-health","11":"tag-icer","12":"tag-injectable-drug","13":"tag-lifestyle-modification","14":"tag-medication","15":"tag-metabolic-risk-factors","16":"tag-novo-nordisk","17":"tag-semaglutide","18":"tag-the-institute-for-clinical-and-economic-review","19":"tag-united-states","20":"tag-unitedstates","21":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/115186190694996188","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/218392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=218392"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/218392\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/218393"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=218392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=218392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=218392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}