{"id":247312,"date":"2025-09-22T22:08:16","date_gmt":"2025-09-22T22:08:16","guid":{"rendered":"https:\/\/www.europesays.com\/us\/247312\/"},"modified":"2025-09-22T22:08:16","modified_gmt":"2025-09-22T22:08:16","slug":"genomic-drivers-of-triple-negative-breast-cancer-in-african-american-women-clinical-implications","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/247312\/","title":{"rendered":"Genomic Drivers of Triple-Negative Breast Cancer in African American Women: Clinical Implications"},"content":{"rendered":"<p>In this interview, Song Yao, MD, of Roswell Park Comprehensive Cancer Center, discusses new genomic insights into triple-negative breast cancer (TNBC) in African American women. He explains the unexpected near-universal prevalence of TP53 mutations, the role of HRD-related versus aging-related signatures, and what these findings mean for treatment strategies and future clinical trials. Dr. Yao also explores potential genetic and non-genetic drivers of TNBC disparities and highlights emerging areas for further research.<\/p>\n<p>Transcript<\/p>\n<p><strong>Your study found TP53 mutations in nearly all tumors. What do you think explains this very high prevalence?<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"In this interview, Song Yao, MD, of Roswell Park Comprehensive Cancer Center, discusses new genomic insights into triple-negative&hellip;\n","protected":false},"author":3,"featured_media":247313,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[815,159,67,132,68],"class_list":{"0":"post-247312","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-united-states","11":"tag-unitedstates","12":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/115250233856862001","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/247312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=247312"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/247312\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/247313"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=247312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=247312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=247312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}