{"id":251183,"date":"2025-09-24T13:31:14","date_gmt":"2025-09-24T13:31:14","guid":{"rendered":"https:\/\/www.europesays.com\/us\/251183\/"},"modified":"2025-09-24T13:31:14","modified_gmt":"2025-09-24T13:31:14","slug":"indianapolis-colts-vs-los-angeles-rams-picks-odds-for-nfl-week-4-game","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/251183\/","title":{"rendered":"Indianapolis Colts vs Los Angeles Rams picks, odds for NFL Week 4 game"},"content":{"rendered":"

\"play\"<\/p>\n

NFL Week 3 overreactions<\/p>\n

USA Today’s Lorenzo Reyes breaks down the biggest NFL storylines from Week 3.<\/p>\n

Sports Seriously<\/p>\n

The Indianapolis Colts<\/a> and Los Angeles Rams<\/a> play on Sunday, Sept. 28, at the Rams’ SoFi Stadium in a game on the NFL Week 4 schedule<\/a>.<\/p>\n

Which team will win the NFL Week 4 game<\/a>?<\/p>\n

Check out these\u00a0NFL Week 4 picks<\/a> and NFL Week 4 predictions<\/a>\u00a0for the game, which can be seen at 1:05 p.m. MST on FOX<\/a> (stream with FUBO<\/a>).<\/p>\n

The Rams are a 3.5-point favorite over the Colts in NFL Week 4 odds<\/a> for the game, courtesy of BetMGM Sportsbook<\/a>.<\/p>\n

Los Angeles is -190 on the moneyline, while Indianapolis is +155. The over\/under (point total) is set at 49.5 points.<\/p>\n

NFL Week 4 picks:<\/strong> Seahawks at Cardinals<\/a> | Vikings vs Steelers<\/a> | Commanders at Falcons<\/a> | Saints at Bills<\/a> | Browns at Lions<\/a> | Titans at Texans<\/a> | Panthers at Patriots<\/a> | Chargers at Giants<\/a> | Eagles at Buccaneers<\/a> | Colts at Rams<\/a> | Jaguars at 49ers<\/a> | Ravens at Chiefs<\/a> | Bears at Raiders<\/a> | Packers at Cowboys<\/a> | Jets at Dolphins<\/a> | Bengals at Broncos<\/a> | The Republic’s score predictions<\/a><\/p>\n

Watch Colts at Rams live on FUBO (free trial)<\/a><\/p>\n

Jeremy Cluff writes: “The Colts are one of three undefeated teams remaining in the AFC and are perhaps the surprise of the NFL this season. Still, it would surprise us if Daniel Jones were able to lead Indianapolis to a win over the Rams on the road. The Rams will be mad after blowing the game against the Philadelphia Eagles in NFL Week 3.”<\/p>\n

NFL Week 4 picks, predictions: <\/strong>Who will win Colts vs Rams, other pivotal games this week?<\/a><\/p>\n

Bookies.com<\/a>: Bet the Colts with the points vs Rams<\/p>\n

Bill Speros writes: “Indiana Jones visits this week\u2019s Temple of Doom. The Rams limp home after an historic collapse at Philly. They blew a 19-point lead and saw a potential game-winning field goal transformed into an Eagles touchdown that delivered a cover to thousands of delirious Eagles fans at Lincoln Financial Field. The Colts finally punted Sunday in their 41-20 win over Tennessee. They have yet to lose a turnover. Indy’s Jonathan Taylor scored 3 TDs Sunday and led the NFL in rushing heading into Monday night’s Ravens<\/a>-Lions game. The Colts are the NFL’s lone 3-0 team ATS this season. They face a real defense this week, but still get the cover.”<\/p>\n

NFL power rankings Week 4: <\/strong>Where are Los Angeles Rams, Indianapolis Colts ranked now?<\/a><\/p>\n

The site’s formula predicts that the Colts will win the NFL Week 4 game against the Rams.<\/p>\n

NFL Week 4 odds: <\/strong>Point spreads, moneylines, over\/unders for betting on Colts vs Rams, more games<\/a><\/p>\n

ESPN<\/a>: Rams have a 57% chance to beat Colts on Sunday<\/p>\n

The site gives the Colts a 42.6% shot at winning the NFL Week 4 game, with the remaining percentage accounting for a tie.<\/p>\n

NFL Week 4 schedule: <\/strong>Television channels, how to watch, how to stream Rams vs Colts, more games<\/a><\/p>\n

Dimers<\/a>: Rams 26, Colts 20<\/p>\n

It writes: “After extensive simulations, our model gives the Colts a win probability of 29%, while the Rams have a win probability of 71%..<\/p>\n

NFL Week 4 announcers: <\/strong>Television broadcasters, announcing crews for NFL Week 4 schedule<\/a><\/p>\n

Matt Johnson writes: “The Indianapolis Colts have answered every challenge thrown their way this season, entering Week 4 as the most unexpected undefeated team in the NFL. That might come to an end this Sunday against the Los Angeles Rams. Sean McVay will find a way to keep Puka Nacua away from Charvarius Ward, attacking the Colts\u2019 CB2 vulnerability. More importantly, Los Angeles has the defensive line that\u2019s good enough to win enough battles in the trenches against Indianapolis to force the one Daniel Jones interception that decides this game.”<\/p>\n

NFL Week 4 predictions: <\/strong>ESPN matchup predictor’s picks, win probabilities for this week<\/a><\/p>\n

NFL’s highest paid players in 2025:<\/strong>\u00a0Quarterbacks<\/a>\u00a0|\u00a0Running backs<\/a>\u00a0|\u00a0Wide receivers<\/a>\u00a0|\u00a0Tight ends<\/a>\u00a0|\u00a0Offensive linemen<\/a>\u00a0|\u00a0D-linemen<\/a>\u00a0|\u00a0Cornerbacks<\/a>\u00a0|\u00a0Safeties<\/a>\u00a0|\u00a0Linebackers<\/a>\u00a0|\u00a0Edge rushers<\/a>\u00a0|\u00a0Highest paid NFL players: Overall<\/a>\u00a0|\u00a0By position<\/a>\u00a0|\u00a0By team<\/a><\/p>\n

Reach Jeremy Cluff\u00a0at\u00a0jeremy.cluff@arizonarepublic.com<\/a>.\u00a0Follow him on X, formerly Twitter\u00a0@Jeremy_Cluff.<\/a><\/p>\n

Support local journalism: Subscribe to\u00a0azcentral.com<\/a>\u00a0today.<\/p>\n