{"id":272978,"date":"2025-10-02T22:33:18","date_gmt":"2025-10-02T22:33:18","guid":{"rendered":"https:\/\/www.europesays.com\/us\/272978\/"},"modified":"2025-10-02T22:33:18","modified_gmt":"2025-10-02T22:33:18","slug":"big-ten-and-biggest-college-football-game-expert-picks-and-predictions-for-week-6","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/272978\/","title":{"rendered":"Big Ten and biggest college football game expert picks and predictions for Week 6"},"content":{"rendered":"

It’s tradition now. Every year (and every week of the season), we have a little friendly competition among our writers for world domination when it comes to picking the\u00a0Big Ten<\/a>\u00a0football games and some of the bigger college football contests throughout the season once conference play gets into full swing.<\/p>\n

Though we never really know, Ohio State<\/a>,\u00a0Oregon<\/a>,\u00a0and Penn State<\/a> are getting a lot of national notoriety and were picked by media members to be the three teams contending for league superiority. You can’t count out Michigan<\/a> despite the loss to Oklahoma<\/a>, and teams like USC<\/a>, Washington<\/a>,\u00a0Iowa<\/a>, Illinois, and\u00a0Nebraska<\/a>\u00a0hope to also be upstarts and surprise folks.<\/p>\n

Advertisement<\/p>\n

So, just how will Week 6 play out in the\u00a0Big Ten? Our writers take turns picking all the games in the Big Ten straight up and against the spread for your wagering and reading consumption \u2014 do with it as you wish.<\/p>\n

As a reminder, if there\u2019s an asterisk next to the pick, that means the team will win, but not cover. If there is a tie, rather than have a cage match or old-fashioned duel, we\u2019ll settle it with less violence and go with the tried, yet true, coin flip, where George Washington has the say.<\/p>\n

EXAMPLE: If Ohio State is favored -3.5 over Michigan:<\/p>\n

If you think Ohio State will win outright and cover: OSU<\/p>\n

Advertisement<\/p>\n

If you think Ohio State will win, but NOT cover: OSU*<\/p>\n

If you think Ohio State will lose: Michigan<\/p>\n

Here are our expert picks for Week 6 as things get deeper into conference play. We throw in the top five non-Big Ten games as well to make it more interesting.<\/p>\n

Standings so far<\/p>\n

Follow Phil Harrison:<\/a>\u00a063-7 SU, 39-31 ATS<\/p>\n

Follow MarkRussell<\/a>: 60-10 SU, 36-34 ATS<\/p>\n

Follow Griffin Dreifeldt<\/a>: 64-6 SU, 42-28 ATS<\/p>\n

Follow Yesh Ginsburg<\/a>: 56-14 SU, 40-30 ATS<\/p>\n

CONSENSUS PICK<\/strong>:\u00a060-10 SU, 42-28 ATS<\/p>\n

\"Michigan's<\/p>\n

Michigan’s Justice Haynes (22) scores in the second half of the college football game between the University of Oklahoma Sooner and the University of Michigan Wolverines at the Gaylord Family \u00c3\u0090 Oklahoma Memorial Stadium in Norman, Okla., Saturday, Sept. 6, 2025.<\/p>\n

Saturday, Oct. 4<\/p>\n

Noon ET | Fox (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Michigan -17.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Advertisement<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Michigan*<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Michigan<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Michigan<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Michigan<\/p>\n

CONSENSUS PICK | Michigan<\/p>\n

Illinois at Purdue\"Sep<\/p>\n

Sep 6, 2025; West Lafayette, Indiana, USA; Purdue Boilermakers running back Devin Mockobee (45) jumps into the end zone for a touchdown during the second half against the Southern Illinois Salukis at Ross-Ade Stadium. Mandatory Credit: Marc Lebryk-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

Noon ET | Big Ten Network (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Illinois -9.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Illinois<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Illinois<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Illinois<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Illinois<\/p>\n

CONSENSUS PICK | Illinois<\/p>\n

\"Sep<\/p>\n

Sep 27, 2025; University Park, Pennsylvania, USA; Penn State Nittany Lions head coach James Franklin reacts during the fourth quarter against the Oregon Ducks at Beaver Stadium. Mandatory Credit: James Lang-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

3:30 p.m. ET | CBS\/Paramount+ (Stream fuboTV (watch here<\/a>))<\/p>\n

Advertisement<\/p>\n

Betting Line<\/strong>\u00a0| Penn State -24.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Penn State<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Penn State<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Penn State<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Penn State<\/p>\n

CONSENSUS PICK: Penn State<\/p>\n

\"Sep<\/p>\n

Sep 27, 2025; Seattle, Washington, USA; Ohio State Buckeyes wide receiver Jeremiah Smith (4) runs for yards after the catch against Washington Huskies cornerback Dylan Robinson (6) during the first quarter at Husky Stadium. Mandatory Credit: Joe Nicholson-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

3:30 p.m. ET | Big Ten Network (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Washington -6.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Washington<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Washington<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Washington<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Washington<\/p>\n

CONSENSUS PICK | Washington<\/p>\n

Northwestern at UL-Monroe\"Aug<\/p>\n

Aug 30, 2025; New Orleans, Louisiana, USA; Northwestern Wildcats quarterback Preston Stone (8) passes against Tulane Green Wave during the second half at Yulman Stadium. Mandatory Credit: Stephen Lew-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

3:30 p.m. ET | Big Ten Network (Stream fuboTV (watch here<\/a>))<\/p>\n

Advertisement<\/p>\n

Betting Line<\/strong>\u00a0| Northwestern -11.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Northwestern<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Northwestern<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Northwestern<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Northwestern<\/p>\n

CONSENSUS PICK | Northwestern<\/p>\n

\"Sep<\/p>\n

Sep 6, 2025; Lincoln, Nebraska, USA; Nebraska Cornhuskers running back Emmett Johnson (21) runs against the Akron Zips during the second quarter at Memorial Stadium. Mandatory Credit: Dylan Widger-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

7:30 p.m. ET | NBC\/Peacock (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Nebraska -11.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Nebraska*<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Nebraska*<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Nebraska*<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Nebraska<\/p>\n

CONSENSUS PICK | Nebraska<\/p>\n

\"Ohio<\/p>\n

Ohio State Buckeyes wide receiver Jeremiah Smith (4) catches a 47-yard touchdown pass in front of Ohio Bobcats cornerback Michael Mack II (9) during the second half of the NCAA football game at Ohio Stadium on Sept. 13, 2025. Ohio State won 37-9.<\/p>\n

Saturday, Oct. 4<\/p>\n

7:30 p.m. ET | NBC\/Peacock (Stream fuboTV (watch here<\/a>))<\/p>\n

Advertisement<\/p>\n

Betting Line<\/strong>\u00a0| Ohio State -24<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Ohio State<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Ohio State<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Ohio State<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Ohio State<\/p>\n

CONSENSUS PICK | Ohio State<\/p>\n

Next … Five biggest national games\"Sep<\/p>\n

Sep 6, 2025; Athens, Georgia, USA; Georgia Bulldogs linebacker Gabe Harris Jr. (0) rushes the passer against the Austin Peay Governors in the third quarter at Sanford Stadium. Mandatory Credit: Brett Davis-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

Noon ET | ABC (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Georgia -20.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Georgia<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Georgia*<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Georgia<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Georgia<\/p>\n

CONSENSUS PICK | Georgia<\/p>\n

\"Sep<\/p>\n

Sep 20, 2025; Austin, Texas, USA; Texas Longhorns head coach Steve Sarkisian leads his team on to the field before a game against the Sam Houston State Bearkats at Darrell K Royal-Texas Memorial Stadium. Mandatory Credit: Scott Wachter-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

3:30 p.m. ET | ESPN (Stream fuboTV (watch here<\/a>))<\/p>\n

Advertisement<\/p>\n

Betting Line<\/strong>\u00a0| Texas -7<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Texas<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Texas<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Texas*<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Texas<\/p>\n

CONSENSUS PICK | Texas<\/p>\n

\"Sep<\/p>\n

Sep 27, 2025; Athens, Georgia, USA; Alabama Crimson Tide wide receiver Isaiah Horton (1) celebrates with offensive lineman Kadyn Proctor (74) after scoring a touchdown against the Georgia Bulldogs in the second quarter at Sanford Stadium. Mandatory Credit: Dale Zanine-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

3:30 p.m. ET | ABC (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Alabama -10.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Alabama<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Alabama<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Alabama*<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Alabama<\/p>\n

CONSENSUS PICK | Alabama<\/p>\n

\"Sep<\/p>\n

Sep 20, 2025; Tallahassee, Florida, USA; Florida State Seminoles wide receiver Michai Danzy (19) scores a touchdown against the the Kent State Golden Flashes during the first half at Doak S. Campbell Stadium. Mandatory Credit: Melina Myers-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

7:30 p.m. ET | ABC Network (Stream fuboTV (watch here<\/a>))<\/p>\n

Advertisement<\/p>\n

Betting Line<\/strong>\u00a0| Miami -4.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Florida State<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Florida State<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Miami<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Miami<\/p>\n

CONSENSUS PICK | Miami<\/p>\n

Mississippi State at Texas A&M<\/a>\"Sep<\/p>\n

Sep 27, 2025; College Station, Texas, USA; Texas A&M Aggies defensive end T.J. Searcy (18) congratulates linebacker Taurean York (21) after a sack in the second half against the Auburn Tigers at Kyle Field. Mandatory Credit: Maria Lysaker-Imagn Images<\/p>\n

Saturday, Oct. 4<\/p>\n

7:30 p.m. ET | SEC Network (Stream fuboTV (watch here<\/a>))<\/p>\n

Betting Line<\/strong>\u00a0| Texas A&M -14.5<\/p>\n

The Picks<\/strong>:<\/p>\n

Phil Harrison (@PhilHarrisonBW)<\/a> | Texas A&M<\/p>\n

Mark Russell (@MarkRussell1975<\/a>) | Texas A&M*<\/p>\n

Griffin Dreifaldt (@griffin_drei<\/a>) | Texas A&M<\/p>\n

Yesh Ginsburg (@yesh222<\/a>) | Texas A&M<\/p>\n

CONSENSUS PICK | Texas A&M<\/p>\n

Contact\/Follow us\u00a0@BuckeyesWire<\/a>\u00a0on X (formerly Twitter) and like our page on\u00a0Facebook\u00a0to follow ongoing coverage of Ohio State news, notes, and opinion.<\/p>\n

This article originally appeared on Buckeyes Wire: Big Ten and big game CFB expert picks and predictions for Week 6<\/a><\/p>\n